Lack of Association Between Polymorphisms in AGT and ATR1 and IgA Nephropathy in a Chinese Population

Gao, Jie; Yu, Qiaoling; Fu, Rongguo; Wei, Linting; Wang, Meng; Dong, Feihong; Wang, Zhe; Yang, Pengfei; Liu, Xinghan; Dai, Zhijun

doi:10.1089/gtmb.2015.0167

Cited by 4 publications

(4 citation statements)

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“…Careful examination identified three studies [ 27 , 29 , 34 ] that were not suitable for inclusion in the Asian subgroup. Gao, et al [ 27 ] reported a 93.9% minor allele frequency in a Chinese population, which differed greatly from other Chinese studies and the 1,000 Genomes Database [ 48 ]. Additionally, Asian populations can be subdivided into East and South Asians, whose allele frequencies may differ [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

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Association between angiotensin II receptor type 1 A1166C polymorphism and chronic kidney disease

et al. 2018

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Studies of the association between angiotensin II receptor type 1 A1166C (AGTR1 A1166C) polymorphism and chronic kidney disease (CKD) risk have yielded conflicting results. We conducted a combined case-control study and meta-analysis to better define this association. The case-control study included 634 end-stage renal disease (ESRD) patients and 739 healthy controls. AGTR1 A1166C genotype was determined using polymerase chain reaction and iPLEX Gold SNP genotyping methods. The meta-analysis included 24 studies found in the PubMed and Cochrane Library databases. Together, the case-control study and meta-analysis included 36 populations (7,918 cases and 6,905 controls). We found no association between the C allele and ESRD (case-control study: OR: 1.02, 95% CI: 0.77–1.37; meta-analysis: OR: 1.07; 95% CI: 0.97–1.18). Co-dominant, dominant, and recessive model results were also not significant. No known environmental factors moderated the effect of AGTR1 A1166C on CKD in our gene-environment interaction analysis. Sensitivity analysis showed an AGTR1 A1166C-CKD association in Indian populations (OR: 1.46, 95% CI: 1.26–1.69), but not in East Asian or Caucasian populations. Additional South Asian studies will be required to confirm the potential role of this polymorphism in CKD.

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Section: Resultsmentioning

confidence: 99%

“…None of the investigative factors moderated the effect of AGTR1 A1166C on CKD. We also excluded the three studies deemed unsuitable for inclusion in the Asian subgroup [ 27 , 29 , 34 ] to avoiding confounding effects. Table 6 shows the meta-regression sensitivity analysis results.…”

Section: Resultsmentioning

confidence: 99%

Association between angiotensin II receptor type 1 A1166C polymorphism and chronic kidney disease

et al. 2018

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“…We found that the angiotensin II receptor type 1 (AGTR1) A1166C polymorphism was frequently reported along with the AGT M235T polymorphism. Of the 34 included studies, 18 provided information on AGTR1 A1166C [ 21 , 23 , 25 – 27 , 31 – 35 , 37 – 40 , 43 , 44 , 49 , 50 ]. The results of the ETMA are shown in Table 5 .…”

Section: Resultsmentioning

confidence: 99%

Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease

Chen

Hsiao

et al. 2017

Oncotarget

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Single nucleotide polymorphisms (SNPs) in renin-angiotensin system (RAS) genes are associated with RAS imbalance and chronic kidney disease (CKD). We performed a case-control study and meta-analysis to investigate the association between angiotensinogen (AGT) M235T polymorphism and CKD. A total of 634 patients with end-stage renal disease and 739 healthy controls were studied. We also searched PubMed and the Cochrane Library to identify prospective observational studies published before December 2015. We found that the TT and MT genotypes were associated with a higher risk of CKD than the MM genotype (odds ratio [OR]: 3.56; 95% confidence interval [CI]: 1.14–11.16 and OR: 2.93; 95% CI: 0.91–9.46, respectively). Thirty-eight study populations were included in the meta-analysis. The T allele was associated with a higher risk of CKD than the M allele in all populations (OR: 1.19; 95% CI: 1.08–1.32). The OR was 1.33 in Asians (95% CI: 1.06–1.67) and 1.10 in Caucasians (95% CI: 1.02–1.18). Evaluation of gene-gene and gene-environment interactions using epistasis analysis revealed an interaction between AGT M235T and angiotensin II receptor type 1 A1166C in CKD (OR: 0.767; 95% CI: 0.609–0.965). Genetic testing for CKD in high-risk individuals may be an effective strategy for CKD prevention.

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“…Our previous studies also found that Megsin [11], MCP-1/CCR2 [12] and TLR1 [13] gene polymorphisms were associated with IgAN susceptibility in a Chinese Han population. However, the rs699 variant in AGT gene and rs5186 polymorphism in ATR1 genes did not confer the risk with IgAN [14]. …”

Section: Introductionmentioning

confidence: 99%

Association Between <b><i>IFN-γ</i></b> Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population

Gao¹,

Wei²,

Liu³

et al. 2017

Kidney Blood Press Res

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Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN.

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Lack of Association Between Polymorphisms in AGT and ATR1 and IgA Nephropathy in a Chinese Population

Abstract: rs699 in the AGT gene and rs5186 in the ATR1 gene were not associated with the risk and clinical outcomes of IgAN.

Cited by 4 publications

References 11 publications

Association between angiotensin II receptor type 1 A1166C polymorphism and chronic kidney disease

Association between angiotensin II receptor type 1 A1166C polymorphism and chronic kidney disease

Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease

Association Between <b><i>IFN-γ</i></b> Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population

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