Association of Matrix Metalloproteinase-1 and Matrix Metalloproteinase-3 Gene Variants with Ischemic Stroke and Its Subtype

Matrix Metalloproteinases as Biomarkers of Atherosclerotic Plaque Instability

“…Sequence variants at the MMP-1 genomic locus may influence risk of coronary heart disease in humans [137]. MMP-1 (-1607 1G/2G) and MMP-3 (-1171 5A/6A) polymorphisms may contribute to different subtypes of ischemic stroke susceptibility [138].…”

Association of the matrix metalloproteinase-3 polymorphisms rs679620 and rs3025058 with ischemic stroke risk: a meta-analysis

“…Finally, seven studies were included in the quantitative analysis. 16 – 22 Among the eligible studies, six studies consisting of 1,840 cases and 1,816 controls assessed rs3025058, 16 , 17 , 19 – 22 while two studies including 382 cases and 442 controls evaluated rs679620. 18 , 19 All stroke patients underwent computerized tomography scan or magnetic resonance imaging of the brain.…”

“…The rs3025058 polymorphism was assessed in Asian and Caucasian studies from 2002 to 2017. 16 , 17 , 19 – 22 For all studies combined, no significant associations were found between rs3025058 genotypes and ischemic stroke risk (5A5A + 6A5A vs 6A6A: OR =1.04, 95% CI: 0.73–1.47; 5A5A vs 6A5A + 6A6A: OR =1.14, 95% CI: 0.74–1.77; 5A5A vs 6A6A: OR =1.11, 95% CI: 0.68–1.80) ( Table 3 and Figure 3 ). Similar results were found for the allele contrast (OR =1.06, 95% CI: 0.79–1.41) ( Table 3 ).…”

Dataset of allele and genotype frequencies of the three functionally significant polymorphisms of the MMP genes in Russian patients with primary open-angle glaucoma, essential hypertension and peptic ulcer

“…The dataset contains the raw data (supplementary Table), frequencies of alleles and genotypes ( Table 1 ) for three SNPs of two MMP genes (rs1799750 MMP1 , rs3918242 and rs17576 MMP9 ) in Russian patients diagnosed with POAG, EH, and PU. These polymorphisms were previously reported for their association with POAG, EH, and PU ( Table 2 ) [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] . The studied SNPs manifest the regulatory potential ( Table 3 ), which is evidenced by several eQTLs ( Table 4 ) and splicing QTLs ( Table 5 ).…”