Association of the matrix metalloproteinase-3 polymorphisms rs679620 and rs3025058 with ischemic stroke risk: a meta-analysis

Zhang, Qiwei

doi:10.2147/ndt.s152256

Cited by 6 publications

(2 citation statements)

References 28 publications

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“…Similarly, the association between the MMP3 rs3025058 polymorphism and disease risk has been widely investigated for conditions such as ischemic stroke [19], coronary disease [20], chronic obstructive pulmonary disease [21] and abdominal aortic aneurysm [22]. Only one study evaluated the role of MMP3 rs3025058 polymorphism in the risk of RCT [13] and it is again the one of Assuncao et al [13] in a Brazilian (Caucasian) population.…”

Section: Discussionmentioning

confidence: 99%

Role of matrix metalloproteases 1/3 gene polymorphisms in patients with rotator cuff tear

et al. 2019

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An association of Matrix Metalloproteinases-1/3 (MMP-1/3) rs1799750/rs3025058 polymorphism with increased risk of rotator cuff tear (RCT) has been reported in a Brazilian population. However, this significant association has not been confirmed in the Chinese population. Genotyping was conducted by polymerase chain reaction (PCR)-restriction fragment length polymorphism and direct sequencing. Our results demonstrated that individuals with the TT genotype had a significantly higher risk of RCT compared with those with the CC genotype. The increased risk of RCT progression was associated with the 2G allele of the rs1799750 polymorphism. No significant association was observed for genotypic and allelic frequencies of the rs3025058 polymorphism. A significant association of the MMP-1 rs1799750 polymorphism was observed with smokers, drinkers and people aged ≥60 years and non-diabetic people. Additionally, the MMP-1 rs1799750 polymorphism was associated with pre-operative stiffness in RCT patients. In conclusion, a significant correlation was identified between the MMP-1 rs1799750 polymorphism and RCT. The MMP-1 rs1799750 polymorphism might be considered as a biomarker of genetically high-risk RCT, helping to clarify the mechanism of RCT.

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Section: Discussionmentioning

confidence: 99%

Role of matrix metalloproteases 1/3 gene polymorphisms in patients with rotator cuff tear

et al. 2019

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“…В 2018 году был опубликован метаанализ ассоциаций полиморфизмов rs679620 и rs3025058 MMP-3 с ИИ [13]. Автор нашел 7 исследований, включающих 5204 человека.…”

Section: основные результатыunclassified

The role of rs3025058 polymorphism in the development of ischemic stroke in patients with cardiovascular diseases (review)

Nikulin

Чернова²,

Никулина³

et al. 2022

CardioSomatics

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Acute cerebrovascular accident (ACC) is a formidable complication of a number of cardiovascular diseases, in a significant percentage of cases leading to disability and mortality. The literature available to us provides information on the role of type 3 matrix metalloproteinase gene (MMP-3) polymorphism in the development of stroke. It is believed that MMP-3 plays an important role in the natural processes of tissue remodeling and pathological processes. The mechanism of regulation of tissue remodeling MMP-3 is based on the activation of procollagenase-1. The associations of the single-nucleotide variant rs3025058 (5A/6A) with the development of ONMK in patients with cardiovascular pathology and risk factors of its development for the implementation of measures of primary prevention of this disease are considered. The article discusses issues related to the role and identification of associations of the single nucleotide variant rs3025058 (5А/6А) with the development of stroke in patients with cardiovascular pathology. When preparing the review, publications were searched in the MEDLINE/PubMed, Scopus, Cochrane Library, PEDro, eLIBRARY databases and Google Scholar. In preparing the literature review, the analysis of publications for the last 15 years is carried out. Represented evidence suggests the need for further study and effective use of the results of the study of the rs3025058 MMP-3 polymorphism for the implementation of primary prevention measures in the development of acute cerebrovascular accident, especially in the families of these patients.

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The Role of the Gene–Gene and Gene–Environment Interactions of Polymorphic Loci of Matrix Metalloproteinases in Forming the Risk of Ischemic Stroke on the Background of Arterial Hypertension in Men

Kalinina

Ponomarenko

Ефремова

et al. 2023

Neurosci Behav Physi

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Association of the matrix metalloproteinase-3 polymorphisms rs679620 and rs3025058 with ischemic stroke risk: a meta-analysis

Cited by 6 publications

References 28 publications

Role of matrix metalloproteases 1/3 gene polymorphisms in patients with rotator cuff tear

Role of matrix metalloproteases 1/3 gene polymorphisms in patients with rotator cuff tear

The role of rs3025058 polymorphism in the development of ischemic stroke in patients with cardiovascular diseases (review)

The Role of the Gene–Gene and Gene–Environment Interactions of Polymorphic Loci of Matrix Metalloproteinases in Forming the Risk of Ischemic Stroke on the Background of Arterial Hypertension in Men

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