Role of matrix metalloproteases 1/3 gene polymorphisms in patients with rotator cuff tear

Abstract

An association of Matrix Metalloproteinases-1/3 (MMP-1/3) rs1799750/rs3025058 polymorphism with increased risk of rotator cuff tear (RCT) has been reported in a Brazilian population. However, this significant association has not been confirmed in the Chinese population. Genotyping was conducted by polymerase chain reaction (PCR)-restriction fragment length polymorphism and direct sequencing. Our results demonstrated that individuals with the TT genotype had a significantly higher risk of RCT compared with those with the CC genotype. The increased risk of RCT progression was associated with the 2G allele of the rs1799750 polymorphism. No significant association was observed for genotypic and allelic frequencies of the rs3025058 polymorphism. A significant association of the MMP-1 rs1799750 polymorphism was observed with smokers, drinkers and people aged ≥60 years and non-diabetic people. Additionally, the MMP-1 rs1799750 polymorphism was associated with pre-operative stiffness in RCT patients. In conclusion, a significant correlation was identified between the MMP-1 rs1799750 polymorphism and RCT. The MMP-1 rs1799750 polymorphism might be considered as a biomarker of genetically high-risk RCT, helping to clarify the mechanism of RCT.

Association between matrix metalloproteinase-3 gene polymorphisms and tendon-ligament injuries: evidence from a meta-analysis

“…Of the remaining 18 items requiring full-text review, another five items were excluded with reasons (two records with insufficient data, one review, one record with irrelevant locus, and one conference abstract). Ultimately, thirteen original studies [ 16 , 17 , 20 – 24 , 26 – 31 ] fell within the scope of this meta-analysis. The flow diagram was presented in Fig.…”

“…All studies were published in English, and the publish year ranged from 2009 to 2020. Injury types in the original studies including rotator cuff tear (RCT) [ 17 , 24 , 26 ], Achilles tendinopathy (ATEN) [ 16 , 20 , 21 , 27 , 28 ], anterior cruciate ligament rupture (ACLI) [ 22 , 23 , 28 , 31 ], Achilles tendon rupture (ARUP) [ 20 , 27 ], patellar tendinopathy (PTEN) [ 30 ], and tibial tendinopathy (TTEN) [ 14 ]. All the included studies were case–control studies, with the exception of Haug et al’s [ 30 ] cohort study.…”

“…Five studies [ 24 , 26 , 28 , 29 , 31 ] with seven cohorts reported the association of rs3025058 and TLIs, including 412 cases and 325 controls. Significant heterogeneity was detected.…”

“…Thus far, a number of studies have looked into MMP-3 polymorphisms and their impact on susceptibility to TLIs, with varying and inconclusive results. Some studies found that MMP-3 polymorphisms were significantly associated with TLIs [ 16 , 17 , 21 , 22 ], while other studies obtained a null association [ 23 , 24 ]. The inconformity may be caused by limited sample sizes, population stratification, clinical heterogeneity, and other factors.…”

The Effect of Doxycycline on Achilles Tendon Repair in a Rat Model

“…MMPs are natural zinc-dependent proteases that have the potential to break down almost all components of the extracellular matrix. After tendon rupture, increased MMPs activity and increased matrix efficiency will cause the collagen network to disappear 6 , 7 .…”