Association of lipoprotein lipase polymorphism rs2197089 with serum lipid concentrations and LPL gene expression

Mo, Xing‐Bo; Li, Xuehui; Wang, Laiyuan; Lu, Xiangfeng; Chen, Shufeng; Li, Hongfan; Huang, Jianfeng; Chen, Jichun; Cao, Jie; Li, Jianxin; Tang, Yi‐Da; Gu, Dongfeng

doi:10.1038/jhg.2012.151

Cited by 5 publications

(3 citation statements)

References 43 publications

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“…The association of LPL polymorphisms with lipid levels has been controversial [ 6 ]. Most of the SNPs studied in this gene are rare and limited either to single families or are restricted to isolated geographic regions, whereas, common variants show differences in allele frequencies among different populations [ 26 ]. In our study, minor allele (G) of the SNP LPL rs328 was found to be protective as its presence lowers TG and raises HDL-C.…”

Section: Discussionmentioning

confidence: 99%

Common variants in the genes of triglyceride and HDL-C metabolism lack association with coronary artery disease in the Pakistani subjects

et al. 2017

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BackgroundSerum Triglyceride (TG) and High Density Lipoprotein (HDL-C) levels are modifiable coronary artery disease (CAD) risk factors. Polymorphisms in the genes regulating TG and HDL-C levels contribute to the development of CAD. The objective of the current study was to investigate the effect of four such single nucleotide polymorphism (SNPs) in the genes for Lipoprotein Lipase (LPL) (rs328, rs1801177), Apolipoprotein A5 (APOA5) (rs66279) and Cholesteryl ester transfer protein (CETP) (rs708272) on HDL-C and TG levels and to examine the association of these SNPs with CAD risk.MethodsA total of 640 subjects (415 cases, 225 controls) were enrolled in the study. The SNPs were genotyped by KASPar allelic discrimination technique. Serum HDL-C and TG were determined by spectrophotometric methods.ResultsThe population under study was in Hardy Weinberg equilibrium and minor allele of SNP rs1801177 was completely absent in the studied subjects. The SNPs were association with TG and HDL-C levels was checked through regression analysis. For rs328, the effect size of each risk allele on TG and HDL-C (mmol/l) was 0.16(0.08) and −0.11(0.05) respectively. Similarly, the effect size of rs662799 for TG and HDL-C was 0.12(0.06) and −0.13(0.0.3) and that of rs708272 was 0.08(0.04) and 0.1(0.03) respectively. The risk allele frequencies of the SNPs were higher in cases than controls, but the difference was not significant (p > 0.05) and SNPs were not associated with CAD risk (p > 0.05). The combined gene score of four SNPs significantly raised TG and lowered HDL-C but did not increase CAD risk.ConclusionThe studied SNPs were associated with TG and HDL-C levels, but not with CAD in Pakistani population under study.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-017-0419-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Common variants in the genes of triglyceride and HDL-C metabolism lack association with coronary artery disease in the Pakistani subjects

et al. 2017

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“…The associations between genotypes and phenotypes can be modified by gene-environment interactions. Effect modification of the associations between LPL SNPs and serum lipid concentrations by interactions with cigarette smoking has been reported (Lee et al, 2004;Kathiresan et al, 2008;Kooner et al, 2008;Pyun et al, 2012;Mo et al, 2013). In the present study, association of the LPL SNP with HDL cholesterol by smoking status was also examined.…”

Section: )mentioning

confidence: 69%

Lipoprotein Lipase Polymorphism rs10503669 is Associated with High-density Lipoprotein Cholesterol Levels in Korean Population

Sull¹,

Eom²,

Jee³

2014

BSL

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High-density lipoprotein (HDL) cholesterol levels are associated with decreased risk of coronary artery disease. Several genome-wide association studies (GWAS) for HDL cholesterol levels have implicated Lipoprotein lipase (LPL) as possibly being causal. Herein, the association between single nucleotide polymorphism (SNP) rs10503669 in the LPL gene and HDL cholesterol levels and triglyceride levels was tested in the Korean population. A total of 994 subjects from Seoul City were included in a replication study with LPL SNP rs10503669. SNP rs10503669 in the LPL gene was associated with mean HDL cholesterol levels (effect per allele 3.13 mg/dL, P<0.0001) and triglyceride levels (effect per allele-18.0 mg/dL, P=0.0026). Subjects with the CA/AA genotype had a 0.42-fold (range 0.23~0.77-fold) lower risk of having abnormal HDL cholesterol levels (<40 mg/dL) than subjects with the CC genotype. When analyzed by gender, the association of LPL was stronger in men than in women. This study clearly demonstrates that genetic variants in LPL influence HDL cholesterol levels and triglyceride levels in Korean adults.

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“…In this study, smoker participants with the minor allele A had a higher LPL activity and therefore increased HDL concentrations. [ 24 ]…”

Section: Resultsmentioning

confidence: 99%

Lipid‐Related Genetic Variants for Personalized Dietary Interventions: A Systematic Review

Rivera-Iñiguez

González-Becerra

Ramos-López

et al. 2023

Molecular Nutrition Food Res

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Dyslipidemias are known risk factors for chronic diseases. Precision nutrition interventions are designed according to characteristics, such as diet, phenotype, and genotype. This systematic review aims to define a panel of genetic variants associated with lipid abnormalities that could be later used in nutrigenetic intervention studies. A systematic review is conducted following the PRISMA-P. Studies published from January 2010 to December 2020 in English language and humans are included from PubMed and ScienceDirect databases. Articles that demonstrate a strong association between polymorphisms (single nucleotide variation) of genes involved in lipid metabolism and increased risk for dyslipidemia are included. A total of 3031 articles are screened, but only 51 articles fulfill the inclusion criteria. The genes included are FABP2, MTTP related to CM synthesis and secretion; LPL, LIPC involved in triglyceride hydrolysis; CETP, APOA1, LCAT, ABCA1, and APOA5 related to lipoprotein metabolism, and APOE, LDLR, SCARB1, APOC3 involved in lipid clearance. In this systematic review, genetic variants related to chylomicron synthesis, triglyceride hydrolysis, lipoprotein metabolism, and lipid clearance demonstrate a strong association with lipid abnormalities, which can be used to design precision nutrition interventions that may help to prevent and treat dyslipidemia effectively.

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Association of lipoprotein lipase polymorphism rs2197089 with serum lipid concentrations and LPL gene expression

Cited by 5 publications

References 43 publications

Common variants in the genes of triglyceride and HDL-C metabolism lack association with coronary artery disease in the Pakistani subjects

Common variants in the genes of triglyceride and HDL-C metabolism lack association with coronary artery disease in the Pakistani subjects

Lipoprotein Lipase Polymorphism rs10503669 is Associated with High-density Lipoprotein Cholesterol Levels in Korean Population

Lipid‐Related Genetic Variants for Personalized Dietary Interventions: A Systematic Review

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