Association of leptin receptor gene Q223R polymorphism on lipid profiles in comparison study between obese and non-obese subjects

Becer, Eda; Mehmetçik, Güldal; Bareke, Halin; Serakıncı, Nedime

doi:10.1016/j.gene.2013.08.003

Cited by 25 publications

(28 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent molecular studies revealed that leptin (LEP) and leptin receptor (LEPR) genes have been used in search for gene variants potentially related to the pathophsiology of human obesity and its' associated complications [9]. Several polymorphisms have been identified in these genes.…”

Section: Introductionmentioning

confidence: 99%

Association between leptin G-2548A gene polymorphism, plasma leptin levels and lipid profiles in Turkish Cypriot obese subjects / Kıbrıslı Türk obez kişilerde leptin G-2548A gen polimorfizmi ile plazma leptin seviyeleri ve lipid profili arasındaki ilişki

Becer¹,

Kızılkanat

Tınazlı

et al. 2016

Turkish Journal of Biochemistry

Self Cite

View full text Add to dashboard Cite

Objective: Leptin (LEP) is a metabolic and neuroendocrine hormone which is present in the circulation in amounts proportional to fat mass that acts to reduce food intake and increase energy expenditure thereby regulating body weight homeostasis. Various polymorphisms are shown to be present in LEP gene which play important roles in obesity and obesity-related metabolic biomarkers. The aim of this study was to investigate the association of one of these polymorphisms, leptin gene G-2548A polymorphism, on obesity in association with body mass index (BMI), lipid parameters, plasma leptin levels and homeostasis model assessment of insulin resistance (HOMA-IR).Methods: The study included 110 obese and 90 non-obese subjects. The LEP G-2548A polymorphism was determined by polymerase chain reaction -restriction fragment length polymorphism (PCR-RFLP). Plasma leptin levels, serum lipid and antropometric parameters were measured.Results: No association was found between LEP gene G-2548A polymorphism and BMI in both study and control groups. Strikingly study group with obese subjects and with the AA genotype had significantly higher serum total cholesterol (p<0.05) than GA and GG genotypes. In obese group, subjects with the AA genotypes had significantly higher leptin (p<0.05) levels than the GG and GA genotypes.Conclusion: Our results suggest that the LEP gene G-2548A polymorphism may not be considered as a genetic risk factor for obesity in Turkish Cypriot population. However, the G-2548A polymorphism appear to be important in regulating leptin and total cholesterol levels in obese group through leptin gene expression and signaling.

show abstract

Section: Introductionmentioning

confidence: 99%

Association between leptin G-2548A gene polymorphism, plasma leptin levels and lipid profiles in Turkish Cypriot obese subjects / Kıbrıslı Türk obez kişilerde leptin G-2548A gen polimorfizmi ile plazma leptin seviyeleri ve lipid profili arasındaki ilişki

Becer¹,

Kızılkanat

Tınazlı

et al. 2016

Turkish Journal of Biochemistry

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our results revealed that LEPR Arg109Arg had a protecting effect against the CVD risk. Previous studies have reported that individuals with the LEPR Arg109Arg genotype have lower risks of hypertension, obesity, dyslipidemia, and diabetes [8,30,31,32], which are all important established risk factors of CVD. As a result, these above studies are likely to give mediated evidence to support our study.…”

Section: Discussionmentioning

confidence: 99%

Leptin Receptor Gene Polymorphism and the Risk of Cardiovascular Disease: A Systemic Review and Meta-Analysis

Sun

2017

IJERPH

View full text Add to dashboard Cite

Objective: Few studies have assessed the association between leptin receptor (LEPR) gene polymorphism and the risk of cardiovascular disease (CVD). Of the few epidemiological studies on this topic, the results are still controversial. Methods: PubMed and Embase were screened for studies from their inception to 9 October 2016. The pooled odds ratio (OR) with the corresponding confidence intervals (CI) were used to measure the effect size for studies that reported the association under allelic, homozygous, and dominant models. Pre-specified characteristics were conducted in the subgroup analysis. Heterogeneity between subgroups was evaluated by meta-regression analysis. Results: Seven eligible studies involving 44,133 participants were included in our meta-analysis. Borderline significant association was observed between the LEPR gene polymorphism (rs1137101, rs1137100, rs6700896, and rs8179183) and the increased risk of CVD with considerable heterogeneity under the allelic model, and the overall pooled OR (95% CI) was 1.10 (0.99, 1.22). The LEPR gene variant rs6700896, 109G allele, and 109GG genotype were significantly associated with the increased risk of CVD. Furthermore, stratified group analysis revealed that the association was more pronounced for stroke. Race-differences might also cause the considerable heterogeneity and non-significant association. Conclusions: This is the first systematic review and meta-analysis to investigate the association between LEPR gene variants and CVD risk. Some LEPR gene variants were significantly associated with the increased risk of CVD. However, the present study is limited in its small number of included studies, considerable heterogeneity, and observational study design. Further research is still warranted to confirm the magnitude of the association.

show abstract

“…To date, the LEPR gene has been associated with several risk factors for ischemic stroke, such as hypertension, 32 higher BMI, impaired glucose metabolism, 33 and dyslipidemia. 6,34 In this study, 3 SNPs of LEPR were analyzed. Our results indicated that there was a relationship between LEPR polymorphism and ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

Association of Leptin Receptor Gene Polymorphisms with Genetic Susceptibility to Ischemic Stroke

Tang

Zhang

et al. 2015

Journal of Stroke and Cerebrovascular Diseases

View full text Add to dashboard Cite

Association of leptin receptor gene Q223R polymorphism on lipid profiles in comparison study between obese and non-obese subjects

Cited by 25 publications

References 32 publications

Association between leptin G-2548A gene polymorphism, plasma leptin levels and lipid profiles in Turkish Cypriot obese subjects / Kıbrıslı Türk obez kişilerde leptin G-2548A gen polimorfizmi ile plazma leptin seviyeleri ve lipid profili arasındaki ilişki

Association between leptin G-2548A gene polymorphism, plasma leptin levels and lipid profiles in Turkish Cypriot obese subjects / Kıbrıslı Türk obez kişilerde leptin G-2548A gen polimorfizmi ile plazma leptin seviyeleri ve lipid profili arasındaki ilişki

Leptin Receptor Gene Polymorphism and the Risk of Cardiovascular Disease: A Systemic Review and Meta-Analysis

Association of Leptin Receptor Gene Polymorphisms with Genetic Susceptibility to Ischemic Stroke

Contact Info

Product

Resources

About