Association of Leptin Receptor Gene Polymorphisms with Genetic Susceptibility to Ischemic Stroke

Tang, Hui; Zhang, Zhen; Li, Zheng Ke; Lin, Jen‐Der; Fang, Ding Zhi

doi:10.1016/j.jstrokecerebrovasdis.2015.05.036

Cited by 10 publications

(13 citation statements)

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“…We further excluded 156 articles by reading the title and the abstract of each article, and the remaining 22 full-text articles were assessed for eligibility. Finally, a total of 7 studies were included in the present study [10,11,12,18,19,20,21]. …”

Section: Resultsmentioning

confidence: 99%

“…The published year of these articles ranged between 2009 and 2015. One of the included articles was conducted in Egyptian subjects [10], two studies were performed in Chinese subjects [12,20], three studies were performed in European [18,21] and American subjects [11], and the other one study was performed in both European and Asian subjects [19]. All articles included both male and female participants.…”

Section: Resultsmentioning

confidence: 99%

“…For instance, Abd El-Aziz et al reported that the carrier of the Gln223Arg polymorphism Gln/Gln genotype decreased the risk of heart failure [10]. However, other studies reported that the 223GG genotype was associated with a significantly increased risk of chronic heart failure or ischemic stroke [11,12]. We speculated that the sample size of only 200 subjects in the study by Abd El-Aziz et al limited the interpretation of their findings [10].…”

Section: Introductionmentioning

confidence: 99%

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Leptin Receptor Gene Polymorphism and the Risk of Cardiovascular Disease: A Systemic Review and Meta-Analysis

Sun

2017

IJERPH

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Objective: Few studies have assessed the association between leptin receptor (LEPR) gene polymorphism and the risk of cardiovascular disease (CVD). Of the few epidemiological studies on this topic, the results are still controversial. Methods: PubMed and Embase were screened for studies from their inception to 9 October 2016. The pooled odds ratio (OR) with the corresponding confidence intervals (CI) were used to measure the effect size for studies that reported the association under allelic, homozygous, and dominant models. Pre-specified characteristics were conducted in the subgroup analysis. Heterogeneity between subgroups was evaluated by meta-regression analysis. Results: Seven eligible studies involving 44,133 participants were included in our meta-analysis. Borderline significant association was observed between the LEPR gene polymorphism (rs1137101, rs1137100, rs6700896, and rs8179183) and the increased risk of CVD with considerable heterogeneity under the allelic model, and the overall pooled OR (95% CI) was 1.10 (0.99, 1.22). The LEPR gene variant rs6700896, 109G allele, and 109GG genotype were significantly associated with the increased risk of CVD. Furthermore, stratified group analysis revealed that the association was more pronounced for stroke. Race-differences might also cause the considerable heterogeneity and non-significant association. Conclusions: This is the first systematic review and meta-analysis to investigate the association between LEPR gene variants and CVD risk. Some LEPR gene variants were significantly associated with the increased risk of CVD. However, the present study is limited in its small number of included studies, considerable heterogeneity, and observational study design. Further research is still warranted to confirm the magnitude of the association.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Leptin Receptor Gene Polymorphism and the Risk of Cardiovascular Disease: A Systemic Review and Meta-Analysis

Sun

2017

IJERPH

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“…A study by Tang et al (17) in 2015 demonstrated that leptin receptors regulate human energy homeostasis, and mutations in leptin receptors cause ischemic stroke by increasing cardiovascular risk factors. A study in 2014 also showed a leptin-mediated blood pressure increase in diet-induced obese rodents (18).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effects of Adipocytokines on Prognosis in Ischemic Cerebrovascular Events

Dem¹,

Düz²,

Işık³

2017

tnd

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Objective: Leptin and adiponectin are the most important adipocytokines and recent studies showed that they may have role in the etiology of ischemic stroke. However, the effect of adipocytokines on stroke is not yet well understood, and related studies are confusing. The aim of this study was to investigate the effects of serum leptin and adiponectin levels on patients with acute ischemic stroke who were admitted to hospital within 24 hours of stroke. Materials and Methods:A total of 59 patients with acute ischemic stroke and 24 healthy individuals similar in age and sex to the patients were enrolled in the study. The Rankin disability scale was performed in order to detect the severity of stroke. Levels of serum leptin and adiponectin were detected using an enzyme-linked immunosorbent assay. In addition, the outcomes of the patients were calculated through differences between the first day Rankin score and the 30 th day Rankin score. Results were compared and the relation with prognosis was investigated. The correlation of leptin and adiponectin levels with stroke severity was analyzed.Results: Thirty-four male and 25 female patients were included in this study. Leptin levels of patients were higher than in the control group. Adiponectin levels did not differ between the patient and control groups. There was no correlation between serum adipocytokine levels and the modified Rankin scale. Conclusion:Serum leptin and adiponectin levels are not associated with the prognosis of ischemic stroke. Even though high levels of leptin may associate with ischemic stroke, this study was not able to show an association with stroke prognosis. Keywords: Leptin, adiponectin, ischemic stroke, prognosisAmaç: Leptin ve adiponektin, adipositokinlerin en önemlileridir ve son yıllarda yapılan çalışmalarda iskemik serebrovasküler olay etiyolojisinde rolü olduğu düşünülmektedir. Ancak adipositokinlerin inme üzerine etkisi ile ilgili yapılan çalışmaların sonuçları çelişkilidir. Bu çalışmada, iskemik inme tanısı ile ilk 24 saat içerisinde hastanemiz acil servisine başvuran hastaların serum leptin ve adiponektin düzeylerinin prognoz ile ilişkisini değerlendirmeyi amaçladık. Gereç ve Yöntem:Çalışmaya hastanemiz acil servisine başvuran 54 akut iskemik inmeli hasta ile 24 sağlıklı kontrol dahil edildi. İnme sonrası özürlülük skorlarını belirlemek amacıyla 1. ve 30. günlerde modifiye Rankin skalası uygulandı. Hastaneye başvurduktan sonraki ilk 24 saat içerisinde venöz kan numuneleri alınarak ELISA metodu ile serum leptin ve adiponektin düzeyleri belirlendi. Prognoz üzerine etkiyi belirlemek için hastaların 1. ay hesaplanan modifiye Rankin skorları ile ilk modifiye Rankin skorları arasındaki fark hesaplandı. Evaluation of the Effects of Adipocytokines on Prognosis in

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“…However, not all those exposed to potential risk factors for ischemic stroke develop the disease, which suggest that genetic factors may influence the pathological progress of ischemic stroke. It has been reported that certain genes have polymorphisms that may affect the pathological process of ischemic stroke; these genes include the phosphodiesterase 4D gene, matrix metalloproteinase-3 gene, the interleukin-1b gene (IL1b), IL-6, IL18, the receptor gene, and pre-microRNA-146a (Bao et al, 2015;Chehaibi et al, 2015;Kumar et al, 2015;Shi et al, 2015;Tang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Association of the interleukin-10 gene -1082A/G genetic polymorphism with risk of ischemic stroke in a Chinese population

et al. 2016

Genet. Mol. Res.

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ABSTRACT.We investigated the possible association between two single nucleotide polymorphisms of IL10 (-1082A/G and -592C/A) and susceptibility to ischemic stroke. In total, 335 patients with proven ischemic stroke and 335 control subjects were recruited from Xinxiang Central Hospital between March 2013 and May 2015. The IL10 -1082A/G and -529C/A polymorphisms were investigated by polymerase chain reaction-restriction fragment length polymorphism. When compared with the control subjects, patients with ischemic stroke were more likely to be male, have a habit of tobacco smoking, have higher BMI, have hypertension or diabetes mellitus, and have higher levels of TC, LDL-C, HDL-C, and TG. The multivariate logistic regression analyses revealed that the AA genotype of IL10 -1082A/G was significantly associated with development of ischemic stroke in a Chinese population compared with the GG genotype (OR = 1.93, 95%CI = 1.15-3.25). In the dominant model, the association between GA+AA genotype of IL10 -1082A/G and risk of ischemic stroke was also significant compared with the GG genotype, and the adjusted OR (95%CI) for the GA+AA genotype was 1.41 (1.02-1.94). Thus, our study suggests that IL10 gene polymorphisms contribute to the development of ischemic stroke.

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Association of Leptin Receptor Gene Polymorphisms with Genetic Susceptibility to Ischemic Stroke

Cited by 10 publications

References 32 publications

Leptin Receptor Gene Polymorphism and the Risk of Cardiovascular Disease: A Systemic Review and Meta-Analysis

Leptin Receptor Gene Polymorphism and the Risk of Cardiovascular Disease: A Systemic Review and Meta-Analysis

Evaluation of the Effects of Adipocytokines on Prognosis in Ischemic Cerebrovascular Events

Association of the interleukin-10 gene -1082A/G genetic polymorphism with risk of ischemic stroke in a Chinese population

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