1980
DOI: 10.1002/1097-0142(19800315)45:6<1472::aid-cncr2820450629>3.0.co;2-a
|View full text |Cite
|
Sign up to set email alerts
|

Association of Kaposi's sarcoma with second primary malignancies possible etiopathogenic implications

Abstract: The association of Kaposi's sarcoma (KS) with second primary cancers, especially of the lymphoreticular system, has been frequently noted. To confirm these reports in a systematic way, data on a series of 92 patients with KS treated at Memorial Sloan-Kettering Cancer Center (MSKCC) 2949-1975 were subjected to extensive statistical analysis. Use was made also 4517 double primaries including all sites, diagnosed at MSKCC 1949-1974, and 1959 simultaneous double primaries from the Third National Cancer Survey. Som… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

8
60
2
2

Year Published

1985
1985
2018
2018

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 217 publications
(72 citation statements)
references
References 41 publications
(1 reference statement)
8
60
2
2
Order By: Relevance
“…4 While a controversial increased incidence of multiple myeloma and other hematopoietic neoplasms in Classic Kaposi Sarcoma has been extensively reported in the literature, 14,16,18,[21][22][23][24][25][26][27][28][29] the suggested link between HHV-8 and multiple myeloma 30 supports an increase, such as noted in our study, in multiple myeloma in Kaposi Sarcoma patients. An increased incidence of other hematopoietic neoplasms was also observed in our cohort.…”
Section: Discussionsupporting
confidence: 80%
See 2 more Smart Citations
“…4 While a controversial increased incidence of multiple myeloma and other hematopoietic neoplasms in Classic Kaposi Sarcoma has been extensively reported in the literature, 14,16,18,[21][22][23][24][25][26][27][28][29] the suggested link between HHV-8 and multiple myeloma 30 supports an increase, such as noted in our study, in multiple myeloma in Kaposi Sarcoma patients. An increased incidence of other hematopoietic neoplasms was also observed in our cohort.…”
Section: Discussionsupporting
confidence: 80%
“…This correlates well with hypothesis that HHV-8 has a role in the etiology of Classic Kaposi Sarcoma as well as in the development of second malignancies. 9,21 Likewise, the Classic Kaposi Sarcoma may be a sign of underlying malignancy.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…8 Patients typically survive an average of 10-15 years following their initial diagnosis and commonly die of an unrelated cause. Secondary malignancies have been reported in 435% of the patients, 12 with approximately half of these tumors being of hematopoietic/lymphoreticular derivation (ie, leukemia, lymphoma, multiple myeloma). Cutaneous lesions are usually first noted in the distal portion of the lower extremities and evolve in stages, consisting initially of purple patches, followed by plaques and nodules.…”
Section: Kaposi Sarcomamentioning
confidence: 99%
“…Herpes saimiri is the closest relative of KSHV on the basis of the identified DNA fragments. It is non-pathogenic in its natural host, the squirrel monkey, but causes polyclonal T-cell lymphomas and acute leukaemia in other primates and can transform human and simian T lymphocytes in vitro (Albrecht et al, 1992 (Safai et al, 1980). In addition, 9/17 Sicilian patients were reported to have had malaria before developing KS (Geddes et al, 1994).…”
Section: Epidemiologymentioning
confidence: 99%