Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma

Hiatt, Kim M.; Nelson, Ann Marie; Lichy, Jack H.; Fanburg‐Smith, Julie C.

doi:10.1038/modpathol.2008.15

Cited by 76 publications

(50 citation statements)

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“…The current study found that only 10,7% of CKS patients with complete follow-up data available had associated a second primary malignancy, a lower occurrence than previously reported in the literature, 9-42%. [33,40-42]. This lower frequency of second primary malignancies is similar to the 18% found in a previous study on Israeli patients by Feurman and al [43].…”

Section: Discussionsupporting

confidence: 87%

Classic Kaposi's sarcoma in morocco: clinico -epidemiological study at the national institute of oncology

et al. 2011

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BackgroundClassic Kaposi's sarcoma (CKS) is a rare disease likely associated with human herpes virus 8 (HHV-8) infection, and occurs predominantly in Jewish, Mediterranean and middle eastern men .There is a dearth of data in Moroccan patients with CKS regarding epidemiology, clinical characteristics and outcomes. This report examines a cohort of patients with CKS evaluated at the national institute of oncology over 11-year period.MethodsA retrospective analysis of patients referred to the national institute of oncology with classical Kaposi sarcoma, between January 1998 and February 2008, was performed. Reviewed information included demographics, clinical and pathological staging, death or last follow-up.ResultsDuring the study period, 56 patients with a diagnosis of CKS have been referred to our hospital. There were 11(19,7%) females and 45 (80,3%) males (male-to-female ratio: 4:1). Mean age at diagnosis was 61,7 ± 15 (range: 15- 86 years). Nodules and/or plaques were the most frequent type of lesion. The most common location was the lower limbs, particularly the distal lower extremity (90%). In addition to skin involvement, visceral spread was evident in 9 cases. The most common visceral involvement sites were lymph nodes (44%), lung (22%), and gastrointestinal tract (22%). Associated lymphoedema was seen in 24 (42%) of the patients. There were 18 stage I patients (32,14%), 8: stage II (14,28%), 21 stage III(37,5%) and 9 stage IV (16,07%). A second primary malignancy was diagnosed in 6 cases (10,7%), none of the reticuloendothelial system.With a median follow-up of 45 months, 38 (67,8) patients are alive, of whom 25 (65,78%) patients with stable disease, five with progressive disease currently under systemic chemotherapy and 8(21,05%) are alive and free of disease, over a mean interval of 5 years.ConclusionThis is the largest reported series in our context. In Morocco, CKS exhibits some special characteristics including a disseminated skin disease at diagnosis especially in men, a more common visceral or lymph node involvement and a less frequent association with second malignancies.

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Section: Discussionsupporting

confidence: 87%

Classic Kaposi's sarcoma in morocco: clinico -epidemiological study at the national institute of oncology

et al. 2011

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“…KS affected mainly men, regardless of KS type . AIDS‐associated KS is associated with homosexual and bisexual relationships . The high prevalence in homosexual and bisexual men may be linked to the increase of HHV8 seroprevalence in relation to several factors such as oroanal or genitoanal sex, sexual promiscuity, HIV seropositivity, duration of homosexual activity, history of sexually transmissible diseases, and the increasing numbers of sexual partners.…”

Section: Discussionmentioning

confidence: 99%

Kaposi's sarcoma: a population‐based cancer registry descriptive study of 57 consecutive cases diagnosed between 1977 and 2009

et al. 2014

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“…KS should not be thought of as exclusively associated with HIV infection. The emergence of KS in non-HIV persons is a rare but existent clinical condition, involving classic Mediterranean, endemic African and the iatrogenic form in patients on immunosuppressive medications4 as in this case. Corticosteroid immunosuppression can be significant even at moderate doses, as evidenced in this case and a previous report of non-HIV KS in an old person with giant cell arteritis 5…”

Section: Answermentioning

confidence: 89%

Pulmonary and cutaneous nodules in an immunocompromised patient

Vlachostergios

Karamagkiolis

Karamitsos

2011

Thorax

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A 74-year-old man was admitted to hospital due to dyspnoea, malaise and purple, plaque-like papular nodules on his hands (figure 1A), soles (figure 1B) and genitalia for a duration of 1 month. He reported a 5-month history of systemic corticosteroid use for treatment of giant cell arteritis. Laboratory tests disclosed severe lymphopenia and hypogammaglobulinaemia. Pancultures and serological tests were negative, including repeated HIV serology. Contrast-enhanced CT of the chest (2.5 mm slice thickness) demonstrated multiple bilateral solid pulmonary nodules with peribronchovascular distribution and a cavitating nodule in the left lower lobe ( figure 1C). Abdominal CT revealed multiple hepatic ring-enhancing lesions ( figure 1D). A bronchoscopy for inspection, bronchoalveolar lavage and transbronchial biopsies was discussed but deemed difficult to be performed safely due to the worsening respiratory status of the patient. Contributors PJV and SK treated the patient and drafted the article. KK critically revised the manuscript. QUESTIONProvenance and peer review Not commissioned; externally peer reviewed.

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Classic Kaposi Sarcoma in the United States over the last two decades: A clinicopathologic and molecular study of 438 non-HIV-related Kaposi Sarcoma patients with comparison to HIV-related Kaposi Sarcoma

Cited by 76 publications

References 39 publications

Classic Kaposi's sarcoma in morocco: clinico -epidemiological study at the national institute of oncology

Classic Kaposi's sarcoma in morocco: clinico -epidemiological study at the national institute of oncology

Kaposi's sarcoma: a population‐based cancer registry descriptive study of 57 consecutive cases diagnosed between 1977 and 2009

Pulmonary and cutaneous nodules in an immunocompromised patient

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