Recent insights into the pathogenesis of Kaposi's sarcoma

Fife, Kate; Bower, Mark

doi:10.1038/bjc.1996.252

Cited by 27 publications

(24 citation statements)

References 49 publications

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“…As immune impairment worsens, so too may the clinical expression of KS. 79 A few studies suggest that patients with KS as their first AIDS-defining illness may actually have a longer survival than patients without KS. 80,81 Early in the AIDS epidemic, the median CD4ϩ T-lymphocyte count was higher at diagnosis of KS than at diagnosis of other AIDS-defining opportunistic infections.…”

Section: Incidencementioning

confidence: 99%

The Epidemiologic, Pathologic, and Clinical Features of AIDS-Associated Pulmonary Kaposi's Sarcoma

Aboulafia

2000

Chest

109

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Section: Incidencementioning

confidence: 99%

The Epidemiologic, Pathologic, and Clinical Features of AIDS-Associated Pulmonary Kaposi's Sarcoma

Aboulafia

2000

Chest

109

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“…KS lesions are characterized by the presence of a gamma-herpes virus, HHV-8, and a complex network of cytokines, angiogenic and growth factors, extracellular matrix components, and integrins. 2,3 Several angiogenic factors have been implicated in the pathogenesis of KS, including factors released by the KS spindle cells, by inflammatory cells, by HHV-8-infected cells and, in the case of AIDSassociated KS (AIDS-KS), by HIV-infected cells. [2][3][4] Among the latter, Tat, the transactivating gene product of the human immunodeficency virus type 1 (HIV-1), is thought to play a role in the initiation and aggressiveness of AIDS-KS.…”

Section: Introductionmentioning

confidence: 99%

Thrombospondin-1 inhibits Kaposi's sarcoma (KS) cell and HIV-1 Tat-induced angiogenesis and is poorly expressed in KS lesions

et al. 1999

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Kaposi's sarcoma (KS), a neoplasm often associated with iatrogenic and acquired immunosuppression, is characterized by prominent angiogenesis. Angiogenic factors released by both KS and host cells, as well as HHV‐8 and HIV viral products, have been implicated in the pathogenesis of this lesion. Angiogenesis is the result of imbalance among angiogenesis promoters and inhibitors, which disrupts homeostasis. The aim of this study was to investigate the expression and mechanism of KS control of thrombospondin‐1 (TSP), a physiological inhibitor of angiogenesis. Immunohistochemical analysis of four KS lesions showed only spotty reactivity for TSP in the stroma and in less than 10 per cent of lesional blood vessels. In addition, the typical KS spindle cells were not stained. In agreement with these findings, decreased levels of TSP were measured with an ELISA assay in the supernatants of cultured KS cells, compared with endothelial cells. In vitro, TSP inhibited the endothelial cell proliferation and motility induced by KS cell supernatants. TSP also prevented endothelial cell motility induced by Tat, a product of HIV‐1 endowed with angiogenic potential and implicated in the pathogenesis of AIDS‐KS. In vivo, TSP inhibited the angiogenic activity exerted by Tat in the Matrigel sponge model. These results suggest that TSP down‐regulation might be permissive for the development of KS‐associated angiogenesis. Copyright © 1999 John Wiley & Sons, Ltd.

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“…Pulmonary KS affects 18±47 % of patients with known cutaneous KS [58,59], and affects the lung parenchyma, pleura or tracheo-bronchial tree. A virus from the herpes family has been identified as the causal agent for Kaposi's sarcoma and is referred to as Kaposi's-sarcoma-associated herpes virus (KSHV) or human herpes virus 8 [60,61,62]. Almost all cases of KS have been documented in either homosexual or bisexual men and their partners.…”

Section: Kaposi's Sarcomamentioning

confidence: 99%

Computed tomography of the thorax in HIV disease

Padley

King

1999

European Radiology

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A wide variety of thoracic disorders can arise in patients infected with the human immunodeficiency virus (HIV), although recent developments in the therapeutic management of AIDS patients has resulted in a changing pattern of chest disease. The use of CT in the diagnosis and management of these thoracic manifestations is discussed along with the CT appearances of the various infectious and non-infectious complications of the acquired immune deficiency syndrome (AIDS) which are commonly encountered in clinical practice.

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Recent insights into the pathogenesis of Kaposi's sarcoma

Cited by 27 publications

References 49 publications

The Epidemiologic, Pathologic, and Clinical Features of AIDS-Associated Pulmonary Kaposi's Sarcoma

The Epidemiologic, Pathologic, and Clinical Features of AIDS-Associated Pulmonary Kaposi's Sarcoma

Thrombospondin-1 inhibits Kaposi's sarcoma (KS) cell and HIV-1 Tat-induced angiogenesis and is poorly expressed in KS lesions

Computed tomography of the thorax in HIV disease

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