Association of Inflammation-Related Gene Polymorphisms With Susceptibility and Radiotherapy Sensitivity in Head and Neck Squamous Cell Carcinoma Patients in Northeast China

Liu, Ying; Zhu, Li; Yao, Hongmin; Zhang, Ye; Kong, Xiangyu; Chen, Liping; Song, Yu; Mu, Anna; Li, Xia

doi:10.3389/fonc.2021.651632

Cited by 6 publications

(4 citation statements)

References 65 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL-4 is a multifunctional cytokine that is produced by various types of epithelial cells, including BC cells. This particular cytokine has been associated with the advancement of breast cancer and the development of resistance to conventional treatment protocols due to the presence of tumor-initiating cells (TICs) (41).…”

Section: Discussionmentioning

confidence: 99%

Associated of Variable Number Tandem Repeat (VNTR) Polymorphism in IL 4 with Susceptibility to Breast Cancer in Iraqi Women

Oun,

Salih

2024

J. Res. Appl. Sci. Biotechnol.

View full text Add to dashboard Cite

Background: Breast cancer (BC) is common disease in the worldwide. Furthermore genetic mutations are known to enhance BC risk. The aim of this research is to examine correlation between the frequency of BC among Iraqi women and a variable number tandem repeat (VNTR) polymorphism in the IL-4 gene. Methods: The study included 74 patients and 54 healthy women. To determine the genotypes of the variable number of tandem repeats (VNTR) in the IL-4 gene, a Polymerase Chain Reaction (PCR) technique was employed. Additionally, a complete blood count (CBC) test was conducted. Logistic regression analyses were performed to evaluate the association between genotypes and the occurrence of BC. Measures of association were computed in the form of odds ratios (OR) and 95% confidence intervals (95% CI). The threshold for statistical significance in both CBC analysis and genotyping analysis was established as a p-value below 0.05. Results: Among the CBC analysis, only the results of RBC (red blood cell count) and WBC (white blood cell count) showed statistical significance at the p = 0.05 level when comparing the study population. However, our investigation identified no association between IL-4 gene variant genotypes and breast cancer in Iraqi women. Other than tumor differentiation and body mass index(p < 0.05), no clinical or pathological features of BC patients were linked to variant genotypes. Conclusion: The study concluded a substantial RBC and WBC relationship between patients and control. However, the IL-4 genetic variation does not appear to affect breast cancer development or progression. However, the IL-4 genetic variation may affect disease prognosis. Thus, more research is needed to determine how IL-4 genetic variation affects breast cancer prognosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Associated of Variable Number Tandem Repeat (VNTR) Polymorphism in IL 4 with Susceptibility to Breast Cancer in Iraqi Women

Oun,

Salih

2024

J. Res. Appl. Sci. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…rs2494732 belongs to an intron polymorphic locus of AKT1 gene, and studies have focused on its association with schizophrenia, 31 psychosis in cannabis users, 32 and cancers, such as head and neck squamous cell carcinoma 33 and non-small cell lung cancer. 34 For the first time, we discovered in the current investigation, those who carried the rs2494732-C allele had a decreased chance of developing NAFLD.…”

Section: Discussionmentioning

confidence: 99%

Genetic Variations of AKT1 are Associated with Risk Screening for Non-Alcoholic Fatty Liver Disease

Ding¹,

Tang²,

Zhang³

et al. 2023

RMHP

View full text Add to dashboard Cite

Protein kinase B (PKB/AKT) has shown a high profile in the research of metabolic diseases. This research sought to determine whether the AKT1 gene's single nucleotide polymorphisms (SNPs) and the risk of developing non-alcoholic fatty liver disease (NAFLD) were related. Patients and Methods: Recruited in this case-control study were 2693 subjects, including 815 with NAFLD and 1878 without NAFLD. Three SNPs of AKT1 (rs2494732, rs2494752 and rs1130233) were genotyped. To examine the correlation between SNPs and NAFLD susceptibility, logistic regression was performed. Results: After adjusting for sex, age, triglyceride and glucose, AKT1 rs2494732-C (all P < 0.05 in co-dominant model, dominant model and additive model) and rs2494752-G (P < 0.05 in co-dominant model) were linked to a lower risk of NAFLD. The combined effect of both SNPs on NAFLD risk was statistically significant, showing a dose dependence (P trend = 0.010). Sex, body mass index, hypertension, hyperglycemia, hypertriglyceridemia, high-density lipoprotein-cholesterol, alanine aminotransferase, and beneficial alleles were all significant predictors of NAFLD risk (all P < 0.05). The prediction model achieved good discrimination, with an area under the receiver operating characteristic curve of 0.779. The Hosmer-Lemeshow test suggested an inadequate calibration of the model (χ 2 = 21.073, P = 0.007). Conclusion: AKT1 rs2494732 and rs2494752 may be related to Chinese NAFLD susceptibility. The prediction model combining both SNPs with clinical factors displays a strong ability to discriminate NAFLD patients. Both SNPs may be exploited to design new models for early screening of NAFLD high-risk population.

show abstract

“…AKT1 rs1130233 polymorphism has been observed to be associated with bladder cancer in Iranian population 16 and head and neck squamous cell carcinoma in Northeast Chinese population. 28 AKT1 rs1130233 A/A genotype has also been observed to have a significant impact on drug response. Giovannetti et al .…”

Section: Discussionmentioning

confidence: 99%

Impact of AKT1 polymorphism on DNA damage, BTG2 expression, and risk of colorectal cancer development

Zubair

Khan

Imran

2022

Radiology and Oncology

View full text Add to dashboard Cite

Background AKT, also called protein kinase B, is a serine-threonine kinase that functions as a mediator of PI3K-Akt-mTOR signaling pathway and plays an important role in an array of cellular processes. Many single nucleotide polymorphisms (SNP) in AKT gene have been observed to be associated with various types of cancers. In the current research the association of a functional SNP rs1130233 in AKT, depicting G to A transition, was studied with AKT activation, DNA damage, an early response B-cell translocation gene 2 (Btg2) expression and risk of colorectal cancer (CRC) development. Patients and methods A total 197 population-based controls and 200 CRC patients were genotyped for SNP rs1130233. AKT expression, activation and BTG2 expression were determined in GG, AG and AA genotype carriers. DNA damage was determined through comet assay. Results The heterozygous AG genotype (55.67%) was more prevalent in the local population compared to homozygous wild type GG (37.78%) and homozygous AA genotypes (6.55%). Moreover, AG and AA alleles were observed to be significant contributors (P = 0.01, OR = 1.80, CI = 1.18 to 2.74, and P = 0.001, OR = 5.00, CI = 1.90 to 13.18, respectively) in increasing the risk of CRC. The immunoblot analysis revealed that G to A transition decreased the expression and activation of AKT. Moreover, AG and AA genotypes of AKT1 rs1130233 showed a significant increase in DNA damage and Btg2 expression. Conclusions The data concludes that G to A substitution is a risk factor for CRC development involving a decrease in AKT expression and activation and increase in DNA damage.

show abstract

Association of Inflammation-Related Gene Polymorphisms With Susceptibility and Radiotherapy Sensitivity in Head and Neck Squamous Cell Carcinoma Patients in Northeast China

Cited by 6 publications

References 65 publications

Associated of Variable Number Tandem Repeat (VNTR) Polymorphism in IL 4 with Susceptibility to Breast Cancer in Iraqi Women

Associated of Variable Number Tandem Repeat (VNTR) Polymorphism in IL 4 with Susceptibility to Breast Cancer in Iraqi Women

Genetic Variations of AKT1 are Associated with Risk Screening for Non-Alcoholic Fatty Liver Disease

Impact of AKT1 polymorphism on DNA damage, BTG2 expression, and risk of colorectal cancer development

Contact Info

Product

Resources

About