Association of IL-1β +3953 C and HLA-DRB1*15 with Coronary Artery and Rheumatic Heart Diseases in South India

Sreekanth, M.; Basha, S K Esdan; Kumar, G Arun; Govindaraju, S.; Nayar, N Pradeep; Pitchappan, Ramasamy

doi:10.1016/j.humimm.2016.08.003

Cited by 11 publications

(4 citation statements)

References 33 publications

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“…Altered expression of FA2H [441], DSCAM (DS cell adhesion molecule) [442], OLIG2 [328], PCDH15 [443], GRID2 [424], CTTNBP2 [444], AFF2 [445], SYNE2 [446] and EGFR (epidermal growth factor receptor) [447] are associated with autism spectrum disorder. FA2H [111], SERPINA1 [448], HOXB9 [113], TGM2 [449], LRRK2 [450], ROS1 [451], CFC1 [452], GDF3 [453], TF (transferrin) [121], RXFP1 [454], RELN (reelin) [455], HTR2C [456], MYL7 [457], DYSF (dysferlin) [458], GJA5 [459], IRX1 [460], TLL1 [461], SUCNR1 [462], KERA (keratocan) [463], TFAP2B [464], HOXA5 [465], ACSL6 [466], DSCAM (DS cell adhesion molecule) [467], MSR1 [468], REN (renin) [64], VEGFC (vascular endothelial growth factor C) [469], TLR2 [470], PCSK2 [471], FGF12 [472], SLC22A3 [142], HSPB7 [473], CSRP3 [474], KLRD1 [475], PTPRO (protein tyrosine phosphatase receptor type O) [476], IL7R [477], CUX2 [478], ACAN (aggrecan) [479], SHH (sonic hedgehog signaling molecule) [480], MEOX1 [481], AGTR1 [482], VTN (vitronectin) [483], SIRT2 [79], RBP4 [484], IL2RG [485], EPAS1 [486], CDH13 [487], TRPC6 [488], MMP3 [261], PCDHGA3 [489], FGF19 [490], TBX18 [491], HLA-DRB1 [492]. CD74 [493], VWF (von Willebrand factor) [267], MTTP (microsomal triglyceride transfer protein) [494], ANGPT2 [184], AKR1C3 [495], NEDD4L [496], CASP1 [497], LDB2 [498], CHRNA5 [499], CCND2 [500], BRCA2 [97], ZBTB20 […”

Section: Discussionmentioning

confidence: 99%

Identification of key genes and signaling pathway in the pathogenesis of Huntington's disease via bioinformatics and next generation sequencing data analysis

Vastrad,

Vastrad

2024

Preprint

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Huntington's disease (HD) is the primary cause of progressive motor deficits, psychiatric symptoms, and cognitive impairment. The exact molecular mechanisms of HD pathogenesis are largely unknown. This investigation aims to identify the hub genes, miRNA and TFs in HD and explore their potential molecular regulatory network. Next generation sequencing (NGS) dataset (GSE105041) was extracted from the Gene Expression Omnibus (GEO) database. An integrated bioinformatics pipeline including identification of differentially expressed genes (DEGs), Gene ontology and REACTOME pathway enrichment analysis, protein-protein interaction (PPI) network and module analysis, miRNA-hub gene regulatory network analysis and TF-hub gene regulatory network analysis, and receiver operating characteristic curve (ROC) analysis were applied to identify hub genes, miRNA and TFs, and key drivers of HD pathogenesis. We identified 958 DEGs in the discovery phase, consisting of 479 up regulated genes and 479 down regulated genes. GO and REACTOME enrichment analyses of the 479 up regulated genes and 479 down regulated genes showed that they were mainly involved in multicellular organismal process, developmental process, signaling by GPCR and MHC class II antigen presentation. Further analysis of the PPI network using Cytoscape and PEWCC plugins identified 10 hub genes, including LRRK2, MTUS2, HOXA1, IL7R, ERBB3, EGFR, TEX101, WDR76, NEDD4L and COMT. Possible target miRNAs and TFs, including hsa-mir-1292-5p, hsa-mir-4521, ESRRB and SREBF1, were predicted by constructing a miRNA-hub gene regulatory network analysis and TF-hub gene regulatory network. This investigation used bioinformatics methods to explore the molecular pathogenesis of HD, and identified potential molecular markers. These molecular markers might provide novel ideas and methods for the early diagnosis, treatment, and monitoring of HD.

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Section: Discussionmentioning

confidence: 99%

Identification of key genes and signaling pathway in the pathogenesis of Huntington's disease via bioinformatics and next generation sequencing data analysis

Vastrad,

Vastrad

2024

Preprint

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“…IL‐1β is a protein known by its crucial pathophysiological role in inflammatory disorders and its influence in silicosis susceptibility and/or severity has been investigated in several animal model studies, and in a clinical study . We hypothesized that there is a possible association of the IL1B +3954C>T polymorphism with the severity of silicosis, since this polymorphism has been previously associated with the severity and susceptibility to several inflammatory diseases .…”

Section: Discussionmentioning

confidence: 99%

Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects

Salum

Castro

Moreira

et al. 2019

American J Industrial Med

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Introduction: Silicosis is a fibrotic lung disease resulting from the inhalation of crystalline silica and can be classified as simple or complicated according to the International Labour Organization criteria. Furthermore, individuals exposed to crystalline silica also have a higher risk for the development of tuberculosis (Tb).The contribution of inflammatory cytokines to the risk of silicosis and Tb in different populations has previously been reported. Since genetic background might be related to susceptibility to silicosis and Tb, the study of polymorphisms within IL-1α, IL-1β, and tumor necrosis factor protein-coding genes may contribute to elucidating the genetic basis of these diseases.Methods: Single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction using restriction fragment length polymorphism or by Taqman methodology, in a sample of 102 silica-exposed patients from Brazil.Results: No significant associations were observed between the SNPs studied and the severity of silicosis. However, significant associations were found between Tb and the C allele (odds ratio [OR] = 1.93, 95% confidence interval [CI], 1.01-3.73) and the CC genotype (OR = 2.34, 95% CI, 1.04-5.31) of IL1A −899C>T. The IL1B +3954C>T polymorphism also showed an association with Tb (T allele dominant model OR = 2.38, 95% CI, 1.04-5.41). Conclusion:These preliminary results demonstrate that the IL1A and IL1B gene variations may contribute to some extent to susceptibility to Tb, but not silicosis.However, additional studies are still needed to confirm these results.

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“…Studying the effects of these genes affiliated with the occurrence of CHDs can help design novel therapies for the diagnosis and treatment of vascular disorders. (Sreekanth et al, 2016;Arslan et al, 2017). Point mutations in ADD1 and ACE genes have been observed in causing arterial hypertension (Cieslewicz & Jablecka., 2010).…”

Section: Genetics: Influence On Cardiac Conditionsmentioning

confidence: 99%

A Comprehensive View on Cardiovascular Diseases (CVDs): Genetics, Risk Factors & Preventions

Asif¹,

Khan²,

Arshad³

2021

NJNS

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Cardiovascular Diseases (CVDs) are one of the foremost causes of deaths across the world. This review aims to evaluate the genetics and risk factors involved in CVDs and to assess the preventive measures which can be taken for diminishing the chances of developing CVDs. The goal of this review is to provide researchers and clinicians dealing with vascular disorders with a compendium of data about the genetic causes, risk factors, and preventive strategies to combat the development of CVDs. We searched online databases including PubMed for peer-reviewed scientific papers, case studies and review articles related to CVDs, emphasizing on the role of genetics and risk factors like diabetes, hypertension, smoking, alcohol consumption, obesity, age & gender in the progression of CVDs, and reviewing the role of diet and exercise in the prevention of CVDs. Managing the risk factors involved in CVDs is the most essential step for the inhibition of vascular diseases. Healthy lifestyle interventions consisting of a well-balanced diet and physical activity are very critical for the prevention of CVDs. Trials carried out on model organisms have indicated a direct link between diet and exercise on cardiovascular conditions. Strategies involved in the treatment of vascular diseases should also include low-fat diet plans like consumption of whole grains, fruits, vegetables, yogurts and avoiding high-saturated fat-containing foods with the addition of performing moderate aerobic exercises including cycling, swimming, hiking, and running to eliminate the root of the problem.

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Association of IL-1β +3953 C and HLA-DRB1*15 with Coronary Artery and Rheumatic Heart Diseases in South India

Cited by 11 publications

References 33 publications

Identification of key genes and signaling pathway in the pathogenesis of Huntington's disease via bioinformatics and next generation sequencing data analysis

Identification of key genes and signaling pathway in the pathogenesis of Huntington's disease via bioinformatics and next generation sequencing data analysis

Interleukin 1α and 1β gene variations are associated with tuberculosis in silica exposed subjects

A Comprehensive View on Cardiovascular Diseases (CVDs): Genetics, Risk Factors & Preventions

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