Association of<i>interleukin-10</i>gene single nucleotide polymorphisms with rheumatoid arthritis in a Chinese population

Zhang, Tianping; Lv, Taotao; Xu, Shu-Zhen; Pan, Hai‐Feng; Ye, Dong‐Qing

doi:10.1136/postgradmedj-2017-135441

Cited by 12 publications

(13 citation statements)

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“…Several researches have indicated that the incidences of RA in different ethnic groups, geographical areas are different, and the RA prevalence is approximately 1% around the world (3, 4). It has been revealed that genetic susceptibilities, abnormal metabolic enzymes, aberrant immune response are involved in RA development (5, 6). Latterly, a number of single nucleotide polymorphisms (SNPs), the majority of which are located in the non-coding intervals, are gradually identified to be associated with the susceptibility of this disease according to genome-wide association studies (7, 8).…”

Section: Introductionmentioning

confidence: 99%

Long Non-coding RNAs Genes Polymorphisms and Their Expression Levels in Patients With Rheumatoid Arthritis

et al. 2019

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Long non-coding RNAs (lncRNAs) are increasingly recognized to play important roles in multiple autoimmune diseases. This study aimed to evaluate the association of four lncRNAs (ANRIL, lnc-DC, MALAT1, ZFAS1) genes single nucleotide polymorphisms (SNPs) with susceptibility to rheumatoid arthritis (RA) patients, as well as their expression levels. Seventeen SNPs of the four lncRNAs were genotyped in a cohort of 660 RA patients and 710 controls using improved multiple ligase detection reaction (iMLDR). The lncRNAs expressions in peripheral blood mononuclear cells (PBMCs) from 120 RA patients and 120 controls were detected by qRT-PCR. No significant differences were found for the allele and genotype frequencies distribution of ANRIL SNPs (rs1412830, rs944796, rs61271866, rs2518723, rs3217992), lnc-DC SNPs (rs7217280, rs10515177), MALAT1 SNPs (rs619586, rs4102217, rs591291, rs11227209, rs35138901), ZFAS1 SNPs (rs237742, rs73116127, rs6125607, rs6125608) between RA patients and normal controls (all P > 0.05). The genotype effects of dominant and recessive models were also evaluated, but no significant association was found. In addition, our results demonstrated that the rs944796 G allele, rs2518723 T allele, rs3217992 T allele frequencies were significantly associated with anti-CCP in RA patients (all P < 0.05). The haplotype CGTA frequency for ZFAS1 was significantly higher in RA patients (P = 0.036). Compared with normal controls, the expression levels of ANRIL, lnc-DC, MALAT1, ZFAS1 in PBMCs were significantly reduced in RA patients (all P < 0.001). Moreover, ZFAS1 expression was negatively associated with CRP in RA patients (P = 0.002). In summary, ANRIL, lnc-DC, MALAT1, and ZFAS1 genes SNPs were not associated with RA susceptibility, while altered ANRIL, lnc-DC, MALAT1, ZFAS1 levels in RA patients suggested that these lncRNAs might play a role in RA.

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Section: Introductionmentioning

confidence: 99%

Long Non-coding RNAs Genes Polymorphisms and Their Expression Levels in Patients With Rheumatoid Arthritis

et al. 2019

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“…Rheumatoid arthritis is generally known as a chronic, complex autoimmune disease characterized by has complex genetic backgrounds. 19,20 Several studies have shown that pro-inflammatory cytokines play critical roles in the pathogenesis of multiple autoimmune diseases, including RA and systemic lupus erythematosus (SLE). 21,22 Recent investigations had indicated increased serum resistin level in RA patients when compared to the healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Association of single nucleotide polymorphisms in resistin gene with rheumatoid arthritis in a Chinese population

Zhang

et al. 2018

Clinical Laboratory Analysis

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“…A few IL-10 promoter polymorphic sites have been characterized with determination of three polymorphisms from transcription initiation site at positions -819 (rs1800871), -592 (rs1800872) and -1082 (rs1800896) (-1082) (46). These IL-10 promoter polymorphisms have been the most widely investigated in various diseases: asthma, cardiovascular diseases, diabetic nephropathy, systemic lupus erythematosus, rheumatoid arthritis, chronic periodontitis, Alzheimer's disease (47)(48)(49)(50)(51)(52)(53). Furthermore, these polymorphisms are strongly associated with various serum levels of IL-10 in vivo (54).…”

Section: Snp Selectionmentioning

confidence: 99%

Impact ofIL-10Promoter Polymorphisms and IL-10 Serum Levels on Advanced Laryngeal Squamous Cell Carcinoma and Survival Rate

Pašvenskaitė

Liutkevičienė

Gedvilaitė

et al. 2021

Cancer Genomics Proteomics

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Background/Aim: Prognosis of advanced stages of laryngeal squamous cell carcinoma (LSCC) remains poor. To clarify therapeutic targets and improve survival rate, identification of new specific and prognostic biomarkers of LSCC is required. The study aimed to evaluate the impact of IL-10:rs1800871, rs1800872, rs1800896 single nucleotide polymorphisms (SNPs), and IL-10 serum levels on LSCC development and determine associations of selected SNPs with patient survival rate. Patients and Methods: A total of 300 LSCC patients and 533 controls were included in the study. Genotyping was carried out using RT-PCR; IL-10 serum levels were analyzed by ELISA. Results: Significant associations were identified between IL-10 rs1800871 variants and advanced stage of LSCC patient group in the codominant, recessive and additive models (OR=0. 473, p=0.027; OR=0.510, p=0.040; and OR=0.733; p=0.037). Significant variants of IL-10 rs1800872 were determined in the codominant, recessive and additive models (OR=0. 473, p=0.027; OR=0.510, p=0.040; and OR=0.733, p=0.037). The distribution of IL-10 SNPs genotypes did not impact LSCC patient survival rate (respectively, p=0.952; p=0.952; p=0.991). Conclusion: IL-10:rs1800871 and rs1800872 SNPs are associated with advanced stage of LSCC. The genotypic distribution of IL-10 SNPs does not influence the survival rate of LSCC patients.Laryngeal squamous cell carcinoma (LSCC) represents the largest subgroup of head and neck squamous cell carcinoma (HNSCC) and is one of the most common tumors in the respiratory system (1). In all respiratory tract malignancies, LSCC ranks second in terms of the mortality rate (2). LSCC is more commonly diagnosed in men than women (3). According to Global Cancer Observatory data, 154,977 new male and 22,445 female cases were registered in 2018, demonstrating almost seven-times higher incidence in the male population (4). According to racial disparities, younger age African Americans have a higher incidence and mortality compared to Caucasians (1). Furthermore, race is a prognostic factor for 5-year overall survival for white, black, Hispanic, and Asian patients; 60.6%, 52.7%, 59.5% and, 65.7%, respectively (5). Sophisticated diagnostics tools (video laryngostroboscopy, flexible endoscopy, contact endoscopy), surgical (endolaryngeal laser approach, partial laryngectomy, total laryngectomy) and/or nonsurgical options (advanced radiotherapy and/or chemotherapy) and multidisciplinary team-based decision making are used to choose the most suitable treatment modality for LSCC. However, LSCC patient survival rate of 1-, 3-, 5-, and 10-years have not significantly improved and remain relatively low: 81%, 62%, 53%, and 38%, respectively (6). The low survival rate, especially at advanced stages, might be due to little worrying symptoms such as hoarseness, which delay the diagnosis of LSCC and allow progression of the disease resulting in laryngeal stenosis with dyspnoea and stridor. Also, a lack of screening programs (endoscopic laryngeal examination performed by an otorhino...

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Association ofinterleukin-10gene single nucleotide polymorphisms with rheumatoid arthritis in a Chinese population

Abstract: The rs1800890 variant might contribute to RA susceptibility in the Chinese population. Replication studies in different ethnic groups are required to further examine the critical role of gene variation in the pathogenesis of RA.

Cited by 12 publications

References 38 publications

Long Non-coding RNAs Genes Polymorphisms and Their Expression Levels in Patients With Rheumatoid Arthritis

Long Non-coding RNAs Genes Polymorphisms and Their Expression Levels in Patients With Rheumatoid Arthritis

Association of single nucleotide polymorphisms in resistin gene with rheumatoid arthritis in a Chinese population

Impact ofIL-10Promoter Polymorphisms and IL-10 Serum Levels on Advanced Laryngeal Squamous Cell Carcinoma and Survival Rate

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