Association of single nucleotide polymorphisms in <i>resistin</i> gene with rheumatoid arthritis in a Chinese population

Li, Hong‐Miao; Zhang, Tian‐Ping; Li, Xiaomei; Pan, Hai‐Feng; Ma, Dongchun

doi:10.1002/jcla.22595

Cited by 5 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding disagrees with the study in China. 24 The results of this current study revealed that CRP did not correlate with resistin. This could be due to the observation being made during the period of treatment.…”

Section: Discussioncontrasting

confidence: 46%

Evaluation of serum resistin levels in Iraqi rheumatoid arthritis patients under biological treatment and their correlated clinical disease activity index

Shatha Sabah Shyaa,

Hanaa Naji Abdullah,

Khaled Yassin Zakair

2023

J Pak Med Assoc

View full text Add to dashboard Cite

Objective: The current study aimed to evaluate RA patients’ serum resistin levels and to observe the relationshipbetween disease activity and resistin.Methods: A case-control study was conducted on (100) RA Iraqi patients during treatment with bDMARDs. The firstgroup of 50 patients received etanercept, and the second group of 50 patients were on Rituximab (RTX). The controlgroup comprised of 50 healthy individuals. ELISA was used to evaluate serum Resistin in and anti-CRP. Inflammatorymarkers ESR, and CRP with biochemical tests were conducted. In addition to estimating Clinical Disease Activity scoreI(CDAI) by the physicians; at Baghdad Teaching Hospital.Results: Levels of Resistin of RA treated with RTX were significantly higher (16.30 ± 7.38ng/ml) than in RA treated withETN (10.61±5.85ng/ml) compared to the control group. (6.95±1.70 ng/ml). The resistin level showed a positivecorrelation with Anti-CCP abs which was considered to have a high positive correlation (p< 0.01) in ETN group. Whilethis correlation was lower than the RTX group, the, correlation between resistin, and ESR was the highest in RTX groupwhilst no such correlation was observed in the ETN group. There was a positive correlation with CDAI of RA subgroups(moderate activity (p<0.05), and high activity (p<0.001). The logistic regression of resistin was associated with biologicaltreatment, odds ratio was (OR=1.138, p-value= 0.014, 95% CI.1.025-1.257) during ETN, and RTX independent of CRP.Conclusion: There is an association between serum RSN and anti CRP as a result of disease activity independent ofCRP. resist in levels can be used to determine disease activity to avoid disease progression and erosion.Keywords: Protein, Antibodies, Etanercept, Rituximab, Disease, Physicians

show abstract

Section: Discussioncontrasting

confidence: 46%

Evaluation of serum resistin levels in Iraqi rheumatoid arthritis patients under biological treatment and their correlated clinical disease activity index

Shatha Sabah Shyaa,

Hanaa Naji Abdullah,

Khaled Yassin Zakair

2023

J Pak Med Assoc

View full text Add to dashboard Cite

show abstract

“…Accordingly, a downregulation of resistin gene expression in CD4 Th lymphocytes and CD14 monocytes in RA patients responding to TNF-α inhibitor therapy has recently been demonstrated, showing an increased expression in patients who failed to respond to the therapy [166]. In addition, recent studies in a Chinese population have demonstrated the association of SNP in the resistin gene with RA susceptibility as well as with its clinicopathological characteristics [167,168].…”

Section: Resistinmentioning

confidence: 99%

The Adipokine Network in Rheumatic Joint Diseases

Carrión

Frommer

Pérez‐García

et al. 2019

IJMS

134

View full text Add to dashboard Cite

Rheumatic diseases encompass a diverse group of chronic disorders that commonly affect musculoskeletal structures. Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two most common, leading to considerable functional limitations and irreversible disability when patients are unsuccessfully treated. Although the specific causes of many rheumatic conditions remain unknown, it is generally accepted that immune mechanisms and/or uncontrolled inflammatory responses are involved in their etiology and symptomatology. In this regard, the bidirectional communication between neuroendocrine and immune system has been demonstrated to provide a homeostatic network that is involved in several pathological conditions. Adipokines represent a wide variety of bioactive, immune and inflammatory mediators mainly released by adipocytes that act as signal molecules in the neuroendocrine-immune interactions. Adipokines can also be synthesized by synoviocytes, osteoclasts, osteoblasts, chondrocytes and inflammatory cells in the joint microenvironment, showing potent modulatory properties on different effector cells in OA and RA pathogenesis. Effects of adiponectin, leptin, resistin and visfatin on local and systemic inflammation are broadly described. However, more recently, other adipokines, such as progranulin, chemerin, lipocalin-2, vaspin, omentin-1 and nesfatin, have been recognized to display immunomodulatory actions in rheumatic diseases. This review highlights the latest relevant findings on the role of the adipokine network in the pathophysiology of OA and RA.

show abstract

Adipokines as targets in musculoskeletal immune and inflammatory diseases

González-Rodríguez

Ruiz-Fernández

Cordero-Barreal

et al. 2022

Drug Discovery Today

View full text Add to dashboard Cite

Association of single nucleotide polymorphisms in resistin gene with rheumatoid arthritis in a Chinese population

Abstract: In a ward, our results indicated that resistin gene polymorphisms might affect the genetic predisposition of RA in Chinese population.

Cited by 5 publications

References 34 publications

Evaluation of serum resistin levels in Iraqi rheumatoid arthritis patients under biological treatment and their correlated clinical disease activity index

Evaluation of serum resistin levels in Iraqi rheumatoid arthritis patients under biological treatment and their correlated clinical disease activity index

The Adipokine Network in Rheumatic Joint Diseases

Adipokines as targets in musculoskeletal immune and inflammatory diseases

Contact Info

Product

Resources

About