Association ofADRB2rs1042713 with Obesity and Obesity-Related Phenotypes and Its Interaction with Dietary Fat in Modulating Glycaemic Indices in Malaysian Adults

Abstract

Gene-diet interaction studies have reported that individual variations in phenotypic traits may be due to variations in individual diet. Our study aimed to evaluate (i) the association of ADRB2 rs1042713 with obesity and obesity-related metabolic parameters and (ii) the effect of dietary nutrients on these associations in Malaysian adults. ADRB2 genotyping, dietary, physical activity, anthropometric, and biochemical data were collected from 79 obese and 99 nonobese individuals. Logistic regression revealed no association between ADRB2 rs1042713 and obesity (p=0.725). However, the carriers of G allele (AG + GG genotypes) of rs1042713 were associated with increased odds of insulin resistance, 2.83 (CI = 1.04–7.70, adjusted p=0.042), in the dominant model, even after adjusting for potential confounders. Obese individuals carrying the G allele were associated with higher total cholesterol (p=0.011), LDL cholesterol levels (p=0.008), and total cholesterol/HDL cholesterol ratio (p=0.048), compared to the noncarriers (AA), even after adjusting for potential confounders. Irrespective of obesity, the carriers of GG genotype had significantly lower fasting glucose levels with low saturated fatty acid intake (<7.3% of TE/day) (4.92 ± 0.1 mmol/L vs 5.80 ± 0.3 mmol/L, p=0.011) and high intake of polyunsaturated fatty acid:saturated fatty acid ratio (≥0.8/day) (4.83 ± 0.1 mmol/L vs 5.93 ± 0.4 mmol/L, p=0.006). Moreover, the carriers of GG genotype with high polyunsaturated fatty acid intake (≥6% of TE/day) had significantly lower HOMA-IR (1.5 ± 0.3 vs 3.0 ± 0.7, p=0.026) and fasting insulin levels (6.8 ± 1.6 µU/mL vs 11.4 ± 2.1 µU/mL, p=0.036). These effects were not found in the noncarriers (AA). In conclusion, G allele carriers of ADRB2 rs1042713 were associated with increased odds of insulin resistance. Obese individuals carrying G allele were compromised with higher blood lipid levels. Although it is premature to report gene-diet interaction on the regulation of glucose and insulin levels in Malaysians, we suggest that higher quantity of PUFA-rich food sources in regular diet may benefit overweight and obese Malaysian adults metabolically. Large-scale studies are required to replicate and confirm the current findings in the Malaysian population.

Variants of the cry 1 gene may influence the effect of fat intake on resting metabolic rate in women with overweight of obesity: a cross-sectional study

“…In the present study, we did not find any significant interaction between different types of RMRs across PUFA categories. It has previously been shown that the higher intake of PUFA is beneficial for glycemic indices and lipid profile among individuals who carried G allele of ADRB2 rs1042713 polymorphism [ 60 ]. Moreover, a meta-analysis on feeding trials revealed that PUFA had some effect in improving insulin resistance [ 61 ].…”

Systematically integrative analysis identifies diagnostic and prognostic candidates and small-molecule drugs for lung adenocarcinoma

“…In the 2-gene signature, ADRB2 is a protein coding gene encoding the beta2 adrenergic receptor that belongs to a member of the G protein-coupled receptor (GPCR) superfamily. Many studies have confirmed that several diseases such as asthma ( 72 ), obesity ( 73 ) and type 2 diabetes ( 74 ) were associated with ADRB2 . Recently, researchers have found that ADRB2 was significantly correlated with various aspects related to cancer such as prostate cancer ( 75 ) and breast cancer ( 74 ), which indicates that ADRB2 is related to cell proliferation and apoptosis, tumor growth and metastasis, and angiogenesis.…”

Variants of the Cry 1 Gene May Influence the Effect of Fat Intake on Resting Metabolic Rate In Overweight and Obese Women: A Cross-sectional Study

“…In the present study, we did not nd any signi cant interaction between different types of RMRs across PUFA categories. It has previously been shown that the higher intake of PUFA is bene cial for glycemic indices and lipid pro le among individuals who carried G allele (60). Moreover, a meta-analysis on feeding trials revealed that PUFA had some effect in improving insulin resistance (61).…”