Association of <i>ADAM12</i> gene polymorphisms with knee osteoarthritis susceptibility

Ruan, Yuan; Tang, Jilei; Jiang, Xuefeng; Sun, Huiqing; Nong, Luming; Gu, Yanqing; Mi, Yuanyuan

doi:10.18632/oncotarget.20772

Cited by 10 publications

(12 citation statements)

References 28 publications

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“…Over the last years, different genetic studies have been performed to identify genes that encode for proteins associated with OA susceptibility. From these, the rs3740199 (c.142G> C) polymorphism of ADAM12 gene had been previously associated with KOA in a Thai male population (Poonpet et al, 2016); likewise, several meta-analyses have reported this association (Hu et al, 2017;Ren et al, 2017;Wu et al, 2017). However, we did not find any association for rs3740199 ADAM12 polymorphism in our study, in agreement with other authors (Limer et al, 2009;Kerna et al, 2013;Lou et al, 2014;Wang et al, 2015).…”

Section: Discussionsupporting

confidence: 92%

“…On the contrary, the CC genotype of rs1871054 polymorphism of ADAM12 gene had also been associated with an increased risk for susceptibility to KOA in a Chinese Han population (Lou et al, 2014;Wang et al, 2015). Several meta-analysis studies have also found an association with this polymorphism (Hu et al, 2017;Lv et al, 2017;Ren et al, 2017;Chen et al, 2018). Also, in an Estonian population, the C allele was associated with advanced grades of KOA (Kerna et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…ADAM12 also participates in chondrocyte proliferation and it has been found overexpressed in serum and cartilage from KOA subjects (Okada et al, 2008). However, there are still contradictory results about the association between the ADAM12 gene and susceptibility to KOA in different ethnic groups (Kerna et al, 2013;Lou et al, 2014;Wang et al, 2015;Poonpet et al, 2016;Hao et al, 2017;Hu et al, 2017;Lv et al, 2017;Ren et al, 2017;Wu et al, 2017;Chen et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Analyses of the Genetic Polymorphisms rs3740199 and rs1871054 of the ADAM12 Gene and the Alleles at the rs2073508 Loci of the TGFB1 Gene and Their Contribution to Susceptibility to Primary Knee Osteoarthritis

Muñiz

Galarza

Astorga

et al. 2020

Genetic Testing and Molecular Biomarkers

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To analyze the association of polymorphisms in the ADAM12 (rs3740199 and rs1871054) and TGFB1 (rs2073508) genes with knee osteoarthritis (KOA) in a population from northern Mexico. Methods: A total of 296 individuals were included in the study. Primary KOA was confirmed according to the criteria established by the American College of Rheumatology. A real-time PCR-based DNA genotyping method was used to evaluate the rs3740199, rs1871054, and rs2073508 polymorphisms in 132 cases and 164 controls. Results: Our results demonstrate that the ADAM12 rs3740199 polymorphism was significantly associated with primary KOA under the recessive model ( p = 0.036). However, after performing a multinomial logistic regression model, no significant association was found ( p = 0.722). Furthermore, no associations for the rs1871054 and rs2073508 polymorphisms were observed in this study. Conclusion: These findings suggest that polymorphisms within the ADAM12 and TGFB1 genes may not have a significant influence on primary KOA susceptibility in the Mexican Mestizo population; however, inclusion of other ethnic groups and a larger sample size are needed to more fully analyze the role of these polymorphisms with KOA risk.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analyses of the Genetic Polymorphisms rs3740199 and rs1871054 of the ADAM12 Gene and the Alleles at the rs2073508 Loci of the TGFB1 Gene and Their Contribution to Susceptibility to Primary Knee Osteoarthritis

Muñiz

Galarza

Astorga

et al. 2020

Genetic Testing and Molecular Biomarkers

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“…Second, single genes or single environmental factors may not be likely to have direct effects on PCOS susceptibility, but complex interactions between genetic and environmental factors may be involved in the disease development. The last but not the least, if numbers of included studies were small, false-negative results may be detected for each polymorphism [41].…”

Section: Discussionmentioning

confidence: 99%

Association between VEGF gene polymorphisms (11 sites) and polycystic ovary syndrome risk

Huang¹,

Wang²

2020

Bioscience Reports

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Vascular endothelial growth factor (VEGF) plays a critical role in ovarian folliculogenesis and normal reproductive function. So far, several studies focusing on association between VEGF gene polymorphisms and polycystic ovary syndrome (PCOS). However, above association between the VEGF gene polymorphisms and PCOS susceptibility is uncertain. Hence, we performed a timely meta-analysis containing all current publications to make clear this relationship. We searched articles from the PubMed, Embase and Chinese language (WanFang and CNKI) databases that were published up until May 10, 2019. Finally, we obtained 9 studies, containing 29 case–control studies and 11 different polymorphisms. The odds ratios (OR) and 95% confidence intervals (CI) were revealed association strengths. There were significantly decreased associations between rs2010963 (-634), +9812, +405 polymorphisms and PCOS risk. Nevertheless, there existed increased associations between rs699947 (-2578), rs833061, rs1570360 (-1154), rs3025020, rs3025039 polymorphisms and PCOS susceptibility. Our current analysis suggested VEGF gene polymorphisms may be associated with PCOS risk, which is possible to be expected to become biomarkers of early detection for women.

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“…The candidates have been selected predominantly according to the principle that the product they code for is regulators of both joint formation and maintenance. [ 11 ] A great many of polymorphisms in various genes such as ESR1 , [ 12 , 13 ] VDR , [ 14 , 15 ] ADAM12 , [ 16 , 17 ] MMP3 , [ 18 ] and Asporin [ 19 ] have been demonstrated to be related with risk of OA.…”

Section: Introductionmentioning

confidence: 99%

The association between rs12885713 polymorphism in CALM1 and risk of osteoarthritis

Shi

Gao

et al. 2018

Medicine

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Objective:The single nucleotide polymorphism (SNP) rs12885713 of calmodulin 1 gene (CALM1) has been reported to involve in the etiology of osteoarthritis (OA) in several association studies with limited sample size and conflicting results. The purpose of the present systematic review and meta-analysis was to evaluate and synthesize the currently available data on the correlation between rs12885713 and OA susceptibility.Methods:Six electronic databases including PubMed, EMBASE, ISI Web of Science, CNETRAL, CNKI, and Wanfang were systematically retrieved to identify relevant observational articles published before October 2017. Summary odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were calculated to indicate the association between CALM1 polymorphism and OA. Risk of bias was assessed through the Newcastle-Ottawa Scale. Predetermined subgroups and sensitivity analyses were performed using the RevMan 5.3 software. Publication bias was evaluated by Egger and Begg tests.Results:Overall, 5 case–control studies involving 2183 OA patients 2654 healthy control subjects satisfied the meta-analysis. Recessive model was confirmed to be the best-matching genetic model (TT + TC versus CC). The pooled outcomes indicated that rs12885713 SNP was not significantly associated with OA vulnerability (OR 1.11, 95% CI 0.97, 1.27; P = .12). When stratified by different genders, OA sites, and population descents respectively, still non-significant associations were found.Conclusion:Based on the findings of our present study, the rs12885713 polymorphism of CALM1 did not appear to be associated with OA predisposition.

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Association of ADAM12 gene polymorphisms with knee osteoarthritis susceptibility

Cited by 10 publications

References 28 publications

Analyses of the Genetic Polymorphisms rs3740199 and rs1871054 of the ADAM12 Gene and the Alleles at the rs2073508 Loci of the TGFB1 Gene and Their Contribution to Susceptibility to Primary Knee Osteoarthritis

Analyses of the Genetic Polymorphisms rs3740199 and rs1871054 of the ADAM12 Gene and the Alleles at the rs2073508 Loci of the TGFB1 Gene and Their Contribution to Susceptibility to Primary Knee Osteoarthritis

Association between VEGF gene polymorphisms (11 sites) and polycystic ovary syndrome risk

The association between rs12885713 polymorphism in CALM1 and risk of osteoarthritis

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