Association between <i>VEGF</i> gene polymorphisms (11 sites) and polycystic ovary syndrome risk

Huang, Li; Wang, Lunwen

doi:10.1042/bsr20191691

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…The significant role of rs833061 in recurrent miscarriage is noted in [23]. Associations of this polymorphic locus with the development of congenital heart defects [24], polycystic ovary disease [25], various cancers (ovarian cancer [26], lung cancer [27]), and metabolic diseases (diabetic retinopathy in patients with type 2 diabetes mellitus [28]) are shown.…”

Section: Resultsmentioning

confidence: 96%

Locus rs833061 of the VEGF Gene in Pregnant Women with Preeclampsia Is Associated with Newborn Weight

et al. 2021

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We studied the associations of newborn weight with polymorphic loci of growth factor genes in pregnant women with preeclampsia (PE) and considered their regulatory potential. In the group of pregnant women with PE (n = 190), a molecular genetic study of five polymorphic loci of growth factor genes was performed: rs4444903 EGF, rs833061 VEGFA, rs2981582 FGFR2, rs6214 IGF1, rs1800469 TGFβ1. Newborn somatometry was performed using standard methods. Associations of the studied polymorphic loci with newborn weight were studied using log-linear regression analysis. It was found that the genetic risk factor for the birth of small children in pregnant women with PE is the allele C of the rs833061 polymorphism of the VEGFA gene (p perm = 0.002): women with the T/T genotype have the highest newborn weight (on average 3524 g), while women with the C/C genotype have the minimum newborn weight (on average 3415 g). It is shown that the allele C of polymorphic locus rs833061 is associated with low transcription of the VEGFA gene in the thyroid gland and a higher level of alternative splicing of the VEGFA gene transcript in skeletal muscle, increases the affinity of DNA for transcription factors BCL, Pax-5, and Znf143, and affects the interaction of DNA with more than 20 different regulatory proteins (CTCF, RAD21, ZNF263, MAX, etc.). It is revealed that polymorphism rs833061of the VEGF gene in pregnant women with PE is associated with weight of the newborn and has considerable regulatory potential.

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Section: Resultsmentioning

confidence: 96%

Locus rs833061 of the VEGF Gene in Pregnant Women with Preeclampsia Is Associated with Newborn Weight

et al. 2021

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“…The VEGF gene is located in the chromosome region 6p21.3 5 . Single-nucleotide polymorphisms (SNPs) have been observed in the promoter, intronic, and untranslated regions of the VEGF gene, and several studies have suggested VEGF gene polymorphisms may be associated with PCOS risk [6][7][8] . VEGF rs833061 T and rs2010963 G alleles appear to correlate with altered VEGF expression levels.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms rs2010963 and rs833061 of the VEGF gene in polycystic ovary syndrome

Vicente

Marqui

Gomes

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVE:The polycystic ovary syndrome is the most common endocrine disorder, characterized by the dysregulation of ovarian angiogenesis. This alteration can be related to changes in the activities of the vascular endothelial growth factor (VEGF) gene. Single-nucleotide polymorphisms have been observed in the promoter, intronic, and untranslated regions of the VEGF gene, and several studies have suggested that these polymorphisms may be associated with the risk of polycystic ovary syndrome. This study aimed to investigate the association between rs2010963 and rs833061 polymorphisms and haplotypes of VEGF in the etiology of polycystic ovary syndrome. METHODS: A total of 210 women, 102 diagnosed with polycystic ovary syndrome and 108 controls, participated in this study. The genotyping of the samples was performed by PCR-RFLP and real-time PCR for rs2010963 and rs833061 polymorphisms, respectively. The statistical analyses were performed by the chi-square test and logistic regression model. RESULTS:The clinical characteristics of the patients showed that 75.8% of the patients did not become pregnant, 36.3% had a family history of polycystic ovary syndrome, 58.6% were obese, and about 60% had clinical characteristics of hyperandrogenism. There were no associations between the distribution of rs2010963 (OR 1.24; 95%CI 0.60-2.57; p=0.56) and rs833061 (OR 0.78; 95%CI 0.32-1.92; p=0.59) in patients and controls. CONCLUSIONS: The patients with polycystic ovary syndrome have similar rates of VEGF polymorphisms rs2010963 and rs833061 on the general population.

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Polymorphisms of vascular endothelial growth factor and recurrent implantation failure: a systematic review and meta-analysis

Zeng

Xie

et al. 2021

Arch Gynecol Obstet

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Association between VEGF gene polymorphisms (11 sites) and polycystic ovary syndrome risk

Cited by 5 publications

References 43 publications

Locus rs833061 of the VEGF Gene in Pregnant Women with Preeclampsia Is Associated with Newborn Weight

Locus rs833061 of the VEGF Gene in Pregnant Women with Preeclampsia Is Associated with Newborn Weight

Polymorphisms rs2010963 and rs833061 of the VEGF gene in polycystic ovary syndrome

Polymorphisms of vascular endothelial growth factor and recurrent implantation failure: a systematic review and meta-analysis

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