Association of hypothyroidism with unruptured cerebral aneurysms: a case-control study

Atchaneeyasakul, Kunakorn; Tipirneni, Anita; Zhang, Tony J.; Khandelwal, Priyank; Ambekar, Sudheer; Snelling, Brian; Dharmadhikari, Sushrut; Dong, Chuanhui; Guada, Luis; Ramdas, Kevin; Rundek, Tatjana; Yavagal, Dileep R.

doi:10.3171/2016.10.jns161953

Cited by 10 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, IA patients with thyroid hormone replacement therapy were less likely to present with SAH. There are small series reporting a higher prevalence of atherosclerosis 31 and unruptured IA 32 in individuals with hypothyroidism. Therefore, hypothyroidism and/or thyroid hormone replacement therapy might promote the processes in the intracranial vasculature contributing to stabilization of the IA wall and protection from rupture.…”

Section: Discussionmentioning

confidence: 98%

Regular medication as a risk factor for intracranial aneurysms: A comparative case–control study

Jabbarli

Oppong

Chihi

et al. 2022

European Stroke Journal

View full text Add to dashboard Cite

Background: Previous medical history strongly contributes to the genesis of intracranial aneurysms (IA). A possible impact of regular medication on the occurrence of abdominal aortic aneurysms has been reported. Aim: To evaluate the value of regular medication on the risk of development and rupture of IA. Methods: Data on medication use and related comorbidities were obtained from the institutional IA registry. A 1:1 age- and sex-matched patient sample was collected from the population-based Heinz Nixdorf Recall Study with individuals from the same area. Results: In the analysis comparing IA cohort ( n = 1960) with the matched normal population ( n = 1960), the use of statins (adjusted odds ratio, 1.34 [95% confidence interval 1.02–1.78]), antidiabetics (1.46 [1.08–1.99]), and calcium channel blockers (1.49 [1.11–2.00]) was independently associated with higher risk of IA, whereas uricostatics (0.23 [0.14–0.38]), aspirin (0.23 [0.13–0.43]), beta-blockers (0.51 [0.40–0.66]), and angiotensin-converting enzyme inhibitors (0.38 [0.27–0.53]) were related to lower risk of IA. In the multivariable analysis within the IA cohort ( n = 2446), SAH patients showed higher drug exposure with thiazide diuretics (2.11 [1.59–2.80]), but lower prevalence of remaining antihypertensive medication—beta-blockers (0.38 [0.30–0.48]), calcium channel blockers (0.63 [0.48–0.83]), angiotensin-converting enzyme inhibitors (0.56 [0.44–0.72]), and angiotensin-1 receptor blockers (0.33 [0.24–0.45]). Patients with ruptured IA were less likely to be treated with statins (0.62 [0.47–0.81]), thyroid hormones (0.62 [0.48–0.79]), and aspirin (0.55 [0.41–0.75]). Conclusions: Regular medication might impact the risks related to the development and rupture of IA. Further clinical trials are required to clarify the effect of regular medication on IA genesis.

show abstract

Section: Discussionmentioning

confidence: 98%

Regular medication as a risk factor for intracranial aneurysms: A comparative case–control study

Jabbarli

Oppong

Chihi

et al. 2022

European Stroke Journal

View full text Add to dashboard Cite

show abstract

“…Co-morbidities of group C are primarily detected in women. Specifically, they are diseases like Streptococcal pharyngitis (ICD J02.0) 11 , 12 , chronic obstructive pulmonary disease (ICD J44.8) 13 , hypothyroidism (ICD E03.9) 14 , 15 and panic disorder (ICD F41.0). In men, group C comorbidity is limited to depression (ICD F32.9).…”

Section: Discussionmentioning

confidence: 99%

Complex networks approach to study comorbidities in patients with unruptured intracranial aneurysms

Kivelev,

Saarenpää,

Karlsson

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The role of complex network analysis in patients with diagnosis of unruptured intracranial aneurysm is unexplored. The objective of this study is to assess the applicability of this methodology in aneurysm patients. We retrospectively analyze comprehensive unbiased local digital data of a large number of patients treated for any reason between January 2004 and July 2019. We apply an age-cohort approach to a total of 628,831 patients and construct the diagnostic history of each patient—and include the information how old the patient was when diagnosed for the first time with each diagnosis coded according to International Classification of Diseases. For each cohort of age within a 10 year interval and for each gender, we construct a statistically validated comorbidity network and focused on crucial comorbidity links that the aneurysm code has to other disease codes within the whole network. For all cohorts of different age and gender, the analysis shows that 267 diagnose codes have nearest neighbour statistically validated links to unruptured aneurysm ICD code. Among the 267 comorbidities, 204 (76%) were found in patients aged from 40 to 69-years old. Patterns of connectivity with aneurysms were found for smoking, hypertension, chronic obstructive pulmonary disease, dyslipidemia, and mood disorders. A few uncommon connections are also detected in cohorts of female patients. Our study explored the applicability of network analysis and statistical validation in aneurysm observational study.

show abstract

“…Atchaneeyasakul et al suggested that hypothyroidism was independently associated with unruptured cerebral aneurysms. 31 However, its association with outcome is not yet studied. However, with very small number of hypothyroid patients in the present study, it will not be prudent to draw any conclusion from our study.…”

Section: Discussionmentioning

confidence: 99%

Effect of Comorbidities on the Outcome of Patients with Aneurysmal Subarachnoid Hemorrhage: A Prospective Observational Study

Puri

Mahajan

Jangra

et al. 2022

J Neuroanaesth Crit Care

View full text Add to dashboard Cite

Background The pathophysiological changes following aneurysmal subarachnoid hemorrhage (aSAH) lead to a varied degree of neurological deficit and cognitive decline. The presence of comorbidities can contribute to the progression and course of the disease resulting in high morbidity and mortality. Methods A total of 140 patients with aSAH, scheduled for surgical clipping or endovascular coiling were included. The patients' comorbidities were recorded. The postoperative outcome was evaluated using Glasgow Outcome Scale at 1 month following discharge. Multiple logistic regression analysis was performed to identify variables predicting poor outcome, taking into consideration those variables which were significant in univariate analysis. Results Sixty-six percent of these patients with aSAH had associated comorbidities. In our patient cohort, we found that smoking and hypertension were associated with worse outcome (odds ratio [OR] = 4.63 [confidence interval [CI] = 1.83–11.7] and OR = 2.92 [CI = 1.41–6.01], respectively). Hypothyroidism, diabetes mellitus, coronary artery disease, and asthma did not influence the neurological outcome because of their small number. Conclusion Presence of comorbidities like smoking and hypertension significantly worsen the outcome of these patients with aSAH.

show abstract

Association of hypothyroidism with unruptured cerebral aneurysms: a case-control study

Cited by 10 publications

References 10 publications

Regular medication as a risk factor for intracranial aneurysms: A comparative case–control study

Regular medication as a risk factor for intracranial aneurysms: A comparative case–control study

Complex networks approach to study comorbidities in patients with unruptured intracranial aneurysms

Effect of Comorbidities on the Outcome of Patients with Aneurysmal Subarachnoid Hemorrhage: A Prospective Observational Study

Contact Info

Product

Resources

About