Association of Higher Plasma Vitamin D Binding Protein and Lower Free Calcitriol Levels with Tenofovir Disoproxil Fumarate Use and Plasma and Intracellular Tenofovir Pharmacokinetics: Cause of a Functional Vitamin D Deficiency?

Abstract

(The clinical trial registration number for this study is NCT00490412 and is available online at http://clinicaltrials.gov/ct2/show/ NCT00490412.)

Vitamin D-binding protein: one more piece in the puzzle of acromegalic osteopathy?

“…In fact, bio-available vitamin D is sufficient, despite low total 25(OH) vitamin D levels, in subjects with low levels of VDBP (e.g., patients with liver cirrhosis) [9,10]. Conversely, an increase in serum VDBP may cause a functional vitamin D deficiency even in the presence of normal 25(OH) vitamin D values [14]. As a matter of fact, the potential benefit of measuring bio-available vitamin D concentrations, especially in the presence of abnormalities of VDBP, has been suggested [9,10].…”

Síndrome de Fanconi induzida pelo uso de Tenofovir em pessoa coinfectada HIV-Hepatite B multirresistente

“…O TDF, por exemplo, pode proporcionar uma redução na disponibilidade sanguínea de 1,25-dihidroxivitamina D livre e um aumento na concentração sérica de paratormônio a ponto de reduzir em até 7% a densidade mineral óssea 13 . Alguns estudos mostram, inclusive, que a suplementação de vitamina D3 em usuários de TDF pode reduzir os níveis sanguíneos de paratormônio, independentemente da concentração de vitamina D no sangue, beneficiando a pessoa contra a osteopenia 4,[12][13][14] .…”

“…Alguns estudos mostram, inclusive, que a suplementação de vitamina D3 em usuários de TDF pode reduzir os níveis sanguíneos de paratormônio, independentemente da concentração de vitamina D no sangue, beneficiando a pessoa contra a osteopenia 4,[12][13][14] .…”

Adverse Effect Profile of Tenofovir Disoproxil Fumarate in Hiv Positive Patients - A Prospective Study

“…Ultrasonogram of abdomen was done at the initiation of treatment. 6 and 12 months and in case of any specific reason/need in between.…”

“…5 The most common ADR of TDF are gastrointestinal complaints, headache and asthenia. Tenofovir-associated proximal renal tubulopathy causes excessive renal phosphate and calcium losses and 1-hydroxylation defects of vitamin D. 6 Signs of proximal renal tubular dysfunction include proteinuria, glucosuria, hypophosphatemia, hypouricemia, hypokalemia, low serum bicarbonate and/or elevated serum creatinine. 7 Tenofovir use has been associated with reduced bone mineral density and increases in biomarkers associated with bone metabolism, which may lead to an increase in fracture risk.…”