Association of genetic loci for migraine susceptibility in the she people of China

Lin, Qi-Fang; Fu, Xianguo; Yao, Long-teng; Yang, Jing; Cao, Luoyuan; Xin, Yong-tong; Hou, Jun-xia; Ye, Lin-Feng; Huang, Gen-bin

doi:10.1186/s10194-015-0553-1

Cited by 13 publications

(17 citation statements)

References 21 publications

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“…Our findings differ from those of our previous study that examined the association of these same five SNPs in a She population 9. In contrast to the current study, that previous study found that the rs4379368 SNP did not conform with Hardy-Weinberg equilibrium in the migraine group and that the T allele was more common than the C allele in the She population, possibly indicating the presence of positive genetic selection for the T allele in the She population for migraine.…”

Section: Discussioncontrasting

confidence: 99%

“…We did not assess the relationships of the SNPs evaluated in this study with these migraine-associated characteristics. Also, our previous analysis of a She population identified differences in specific genotypes between sexes 9. In the present study the sex ratio differed between the control (28% males and 72% females) and migraine (19.9% males and 80.1% females) groups ( p =0.057).…”

Section: Discussionsupporting

confidence: 59%

“…The sequencing primers and PCR-RFLP analysis were performed as described previously 9. The PCR-RFLP products were digested with Hph1 for rs4379368 and MspA1 for rs10915437, and separated by agarose gel electrophoresis.…”

Section: Methodsmentioning

confidence: 99%

“…Two previous studies have assessed the association of these five SNPs with migraine susceptibility and/or pathogenesis: one involving a Spanish population8 and the other a She Chinese population from Fujian Province, China 9. She people are genetically distinct from other Chinese ethnic populations and have their own lifestyle and cultural heritage.…”

Section: Introductionmentioning

confidence: 99%

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Migraine Susceptibility Genes in Han Chinese of Fujian Province

Lin

Chen

et al. 2017

J Clin Neurol

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Background and PurposeFive single-nucleotide polymorphisms (SNPs) (rs4379368, rs10504861, rs10915437, rs12134493 and rs13208321) were recently identified in a Western population with migraine. These migraine-associated SNPs have not been evaluated in a Han Chinese population. This study investigated the associations of specific SNPs with migraine in a Han population.MethodsThis was a case-control study of Han Chinese residing in Fujian Province. Polymerase chain reaction—restriction-fragment-length polymorphism analysis and direct sequencing were used to characterize the relationships of SNPs in a control group of 200 subjects and in a migraine group of 201 patients.ResultsThe frequencies of the five SNPs did not differ between patients with migraine and healthy non migraine controls. However, subgroup analysis indicated certain SNPs were more strongly associated with migraine with aura or migraine without aura than with controls. The CT genotype of rs4379368 was more common in migraine patients with aura (75%) than in migraine patients without aura (47.9%) and controls (48.5%) (p<0.05), and the TT genotype of rs10504861 was more common in migraine patients with aura than in controls (8.3% vs. 0.5%) (p<0.05). Meanwhile, the CC genotype of rs12134493 was less common in migraine patients without aura than in controls (80.6% vs. 88%) (p<0.05).ConclusionsOur findings suggest that the rs4379368 and rs10504861 SNPs are markers for susceptibility to migraine with aura and that rs12134493 is a marker for the risk of migraine without aura in this Han population. Future studies should further explore if these associations vary by ethnicity.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 59%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Migraine Susceptibility Genes in Han Chinese of Fujian Province

Lin

Chen

et al. 2017

J Clin Neurol

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“…In our previous epidemiological study on migraines in the She population, the prevalence of migraines was as high as 10.53%, which is significantly higher than that in China overall (4.32%) [6,19]. Based on the five newly identified polymorphic loci from the abovementioned meta-analysis [17], we investigated the genotype distribution and allele frequency of those five polymorphic loci in the She population and Han Chinese to explore their correlation with migraines [20,21]. Our results showed that the SNPs rs4379368 (in c7orf10) and rs13208321 (in FHL5) were potential genetic markers for migraines in the She population [20].…”

mentioning

confidence: 99%

Association between PRDM16, MEF2D, TRPM8, LRP1 gene polymorphisms and migraine susceptibility in the She ethnic population in China

Yang

et al. 2019

CIM

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Background:The prevalence of migraines in the She population, a minority in China, is significantly higher than that in Han Chinese and other Asian populations. Two single nucleotide polymorphisms (SNPs) have been found to be associated with migraine susceptibility in the She population.Purpose: This study investigated four SNPs, identified in genome-wide association studies, within migraine-susceptible loci in Han Chinese for their association with migraine susceptibility in the She population.Methods: Two-hundred unrelated migraine patients and 200 healthy controls were recruited. The SNPs examined included rs2651899 (PRDM16 ), rs2274316 (MEF2D ), rs7577262 (TRPM8) and rs11172113 (LRP1). Genotyping of the SNPs was performed by allele-specific polymerase chain reaction and direct sequencing.Results: No significant differences between the participants with migraines and controls (participants without migraines) were demonstrated in genotypes, alleles and allele carriage frequencies for the four SNPs. A subgroup analysis found that migraine with aura had a lower frequency of C allele positivity in rs2651899 than in healthy controls (59.6% vs. 74.5%, respectively; P < 0.034). Univariate analyses indicated that no genotype of the four SNPs had a significant association with migraines. Males had a lower risk of migraines, and advanced age was a significant risk factor for migraines in females. Conclusion:The SNPs in four migraine susceptible loci in Han Chinese were not risk factors for migraines in a relatively small sample of the She population.

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