Association between PRDM16, MEF2D, TRPM8, LRP1 gene polymorphisms and migraine susceptibility in the She ethnic population in China

Abstract

Background:The prevalence of migraines in the She population, a minority in China, is significantly higher than that in Han Chinese and other Asian populations. Two single nucleotide polymorphisms (SNPs) have been found to be associated with migraine susceptibility in the She population.Purpose: This study investigated four SNPs, identified in genome-wide association studies, within migraine-susceptible loci in Han Chinese for their association with migraine susceptibility in the She population.Methods: Two-hundred unrelated migraine patients and 200 healthy controls were recruited. The SNPs examined included rs2651899 (PRDM16 ), rs2274316 (MEF2D ), rs7577262 (TRPM8) and rs11172113 (LRP1). Genotyping of the SNPs was performed by allele-specific polymerase chain reaction and direct sequencing.Results: No significant differences between the participants with migraines and controls (participants without migraines) were demonstrated in genotypes, alleles and allele carriage frequencies for the four SNPs. A subgroup analysis found that migraine with aura had a lower frequency of C allele positivity in rs2651899 than in healthy controls (59.6% vs. 74.5%, respectively; P < 0.034). Univariate analyses indicated that no genotype of the four SNPs had a significant association with migraines. Males had a lower risk of migraines, and advanced age was a significant risk factor for migraines in females. Conclusion:The SNPs in four migraine susceptible loci in Han Chinese were not risk factors for migraines in a relatively small sample of the She population.

PRDM16, LRP1 and TRPM8 genetic polymorphisms are risk factor for Pakistani migraine patients

“…However, they reported that the SNP is in strong linkage disequilibrium with rs11172113 affects the transcription factor binding site ( Ghosh et al, 2013 ). The same results have been reported from She ethnic and Han-Chinese populations where they were unable to find any association of this SNP with migraine susceptibility ( An et al, 2013 , Fu et al, 2019 ).…”

Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity

“…Similarly, it is known that TRPM8 channels are implicated in inflammatory pain and migraine 7 . The thesis that migraine locus lies in the peripheral nervous system 8 , and the identification of TRPM8 as a candidate susceptibility gene for migraine 9,10 , points to the modulation of TRPM8 channels as a plausible mechanism for the treatment of this pathology 11 .…”

Advances on pathogenesis of migraine in cold regions

“…A large-scale female-based study which included 3 003 migraine patients and 18 108 normal controls unraveled that rs7577262/ TRPM8 was associated with migraine, but showed little selectivity to any characteristics of migraine [19] . However, a rs7577262/TRPM8 correlation study conducted in Fujian province of China obtained an opposite result [20] . Fujian province is located in the southeast coastal area of China and has a typical subtropical climate with an annual average temperature of about 26℃.…”