Migraine Susceptibility Genes in Han Chinese of Fujian Province

Abstract

Background and PurposeFive single-nucleotide polymorphisms (SNPs) (rs4379368, rs10504861, rs10915437, rs12134493 and rs13208321) were recently identified in a Western population with migraine. These migraine-associated SNPs have not been evaluated in a Han Chinese population. This study investigated the associations of specific SNPs with migraine in a Han population.MethodsThis was a case-control study of Han Chinese residing in Fujian Province. Polymerase chain reaction—restriction-fragment-length polymorphism analysis and direct sequencing were used to characterize the relationships of SNPs in a control group of 200 subjects and in a migraine group of 201 patients.ResultsThe frequencies of the five SNPs did not differ between patients with migraine and healthy non migraine controls. However, subgroup analysis indicated certain SNPs were more strongly associated with migraine with aura or migraine without aura than with controls. The CT genotype of rs4379368 was more common in migraine patients with aura (75%) than in migraine patients without aura (47.9%) and controls (48.5%) (p<0.05), and the TT genotype of rs10504861 was more common in migraine patients with aura than in controls (8.3% vs. 0.5%) (p<0.05). Meanwhile, the CC genotype of rs12134493 was less common in migraine patients without aura than in controls (80.6% vs. 88%) (p<0.05).ConclusionsOur findings suggest that the rs4379368 and rs10504861 SNPs are markers for susceptibility to migraine with aura and that rs12134493 is a marker for the risk of migraine without aura in this Han population. Future studies should further explore if these associations vary by ethnicity.

Association between PRDM16, MEF2D, TRPM8, LRP1 gene polymorphisms and migraine susceptibility in the She ethnic population in China

“…Our results showed that the SNPs rs4379368 (in c7orf10) and rs13208321 (in FHL5) were potential genetic markers for migraines in the She population [20]. We subsequently found that rs4379368 and rs10504861 (near MMP16) were markers for susceptibility to migraines with aura, and that rs12134493 (near TSPAN2 ) is a marker for risk of migraines without aura in the Han population in Fujian Province, China [21], suggesting that the migraine susceptible loci are different between the Han and She populations. Because evidence suggests that SNPs in those four migraine susceptible loci might not be risk factors for migraines in the She population, we wanted to explore whether the four SNPs reported to be associated with migraines in Han Chinese (i.e., rs2651899 in PRDM16 [22][23][24][25][26][27], rs2274316 in MEF2D [23,[28][29][30], rs7577262 in TRPM8 [18,28] and rs11172113 in LRP1 [27][28][29][30][31]) were similarly associated with migraine in the She population, which is already shown to have a high prevalence of migraine.…”

“…This study investigated the associations of well-known migraine susceptibility SNPs (rs2651899, rs2274316, rs7577262 and rs11172113) in the She ethnic population of Fujian Province in China. Our previous study investigated the genotype distribution and allele frequency of five polymorphic loci in the She and Han Chinese populations to explore their correlation with migraines [20,21]. Those five loci were the newly identified polymorphic loci from the above-mentioned meta-analysis of 29 GWAS [18].…”

“…In our previous epidemiological study on migraines in the She population, the prevalence of migraines was as high as 10.53%, which is significantly higher than that in China overall (4.32%) [6,19]. Based on the five newly identified polymorphic loci from the abovementioned meta-analysis [17], we investigated the genotype distribution and allele frequency of those five polymorphic loci in the She population and Han Chinese to explore their correlation with migraines [20,21]. Our results showed that the SNPs rs4379368 (in c7orf10) and rs13208321 (in FHL5) were potential genetic markers for migraines in the She population [20].…”

Prevalence of migraine in Han Chinese of Fujian province

“…[13] The Han Chinese represent about 97.8% of the population in Fujian province. Although a recent study investigated migraine susceptibility genes in Han Chinese of Fujian province, [14] little is known regarding the prevalence and epidemiology of migraine in the Han population in this province. Knowledge of prevalence data on migraine, risk factors, and comorbidities are considered crucial in helping to assess the public health burden of migraine.…”