Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study

Renner, Sharon W; Qiao, Yujia; Gmelin, Theresa; Santanasto, Adam J; Boudreau, Robert M.; Walston, Jeremy D.; Perls, Thomas T.; Christensen, Kaare; Newman, Anne B.; Glynn, Nancy W.

doi:10.1007/s40520-021-01923-x

Cited by 18 publications

(14 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results add to the literature that physical activity and physical function were negatively correlated with inflammation, while adiposity was not a predictor or moderator of physical function in this sample. These results align with previous research that investigated the positive impact physical activity can have on physical function (Chase et al, 2017;Dipietro et al, 2019) and add the negative influence of chronic low-level inflammation on physical activity (Sadjapong et al, 2020) and physical function (Renner et al, 2021;Sousa et al, 2016;Tay et al, 2019).…”

Section: Discussionsupporting

confidence: 91%

Physical Activity, Inflammation, and Physical Function in Older Adults: Results From the Health & Retirement Study

Hlebichuk

Gretebeck

Garnier‐Villarreal

et al. 2022

Biological Research For Nursing

View full text Add to dashboard Cite

Physical function declines with aging due to physical and biological changes. The biological process of aging has been associated with increases in systemic inflammation and a greater risk for chronic conditions. In older adults, physical activity aids in maintenance of function. However, the influence of inflammatory biomarkers and adiposity on physical activity and physical function needs to be further explored. Methods: A cross-sectional secondary data analysis from Wave 13 of the Health & Retirement Study (HRS) core biennial data and Venous Blood Study (VBS) was conducted. Structural equation modeling was used to establish the model and test the relationships. Results: Chronic low-level inflammation was moderately negatively correlated with physical activity (r = −0.326) and function (r = −0.367). Latent regressions showed that higher physical activity is associated with better physical function (unstandardized estimate = 0.600, p < .001) while inflammation negatively affects physical function (unstandardized estimate = −0.139, p < .001), and adiposity was not a predictor in the model ( p = 0.055). Conclusion: For older adults, preserving physical function by participation in physical activity and decreasing chronic inflammation are key preventive health strategies for older adults to maintain independence, with a need to further explore pro and anti-inflammatory biomarkers.

show abstract

Section: Discussionsupporting

confidence: 91%

Physical Activity, Inflammation, and Physical Function in Older Adults: Results From the Health & Retirement Study

Hlebichuk

Gretebeck

Garnier‐Villarreal

et al. 2022

Biological Research For Nursing

View full text Add to dashboard Cite

show abstract

“…The fatigue concept introduced in this study is defined as "a subjectively unpleasant symptom that incorporates total body feelings ranging from tiredness to exhaustion, creating an unrelenting overall condition which interferes with individuals' ability to function at normal capacity" [11]. This type of fatigue is a frequently debilitating symptom that strongly predicts a decline in PA and performance [12][13][14]. The fatigue-physical activity association is multifactorial, which can be explained by body composition, physical fitness, and comorbidity [15].…”

Section: Introductionmentioning

confidence: 99%

A pilot study of the moderating effect of gender on the physical activity and fatigue severity among recovered COVID-19 patients

et al. 2022

View full text Add to dashboard Cite

Background Clinical data point toward gender-based differences in COVID-19 severity. However, there is insufficient research examining whether gender predicts physical activity (PA) and fatigue severity in patients recovering from COVID-19. Therefore, this study aimed to characterize the PA and fatigue severity in a cohort of patients recovering from COVID-19 infection and measure the extent to which gender-based differences moderate the relationship of PA with fatigue. Method A cross-sectional survey was conducted in Riyadh, Saudi Arabia. The sample comprised patients recovering from COVID-19 over at least 3 months. Recovered patients were stratified into two groups based on gender. The survey included items pertaining to sociodemographic, a fatigue severity scale and a self-reported international PA questionnaire. Results Eighty-seven patients (44 women and 43 men) met the inclusion criteria. Compared with men, women reported sedentary behavior (70%) and high fatigue severity (64%). A significantly higher number of women had a low PA score compared with men (p = .002). The findings indicated that gender significantly moderates the effect of total PA in metabolic equivalents (METs; min/wk) on fatigue severity [F = 4.8, p = .03, ΔR2 = 0.24]. Conclusions The current study suggests that women might be at risk of higher fatigue severity, in addition to engaging less in PA. Physical activity may plays a significant role in modulate the fatigue severity. Consequently, interventions aimed at promoting physical activity in women stand high chances of addressing the disparity in the distribution of prevalence of fatigue between men and women.

show abstract

“…The observed association became even more prominent in a sub-sample characterized as sedentary old (Supplemental figure 2 a). This is plausible, as physical activity is associated with anti-inflammatory effects also at an older age (32). Moreover, higher DII scores were accompanied by significantly higher IL-6 but not by IL-10 in the old participants, which might imply a failing anti-inflammatory compensatory mechanism contributing to inflammaging (33).…”

Section: Discussionmentioning

confidence: 94%

Dietary Inflammatory Index and Cross-Sectional Associations with Inflammation, Muscle Mass and Function in Healthy Old Adults

Haß

Kochlik

Weber

et al. 2022

The Journal of nutrition, health and aging

View full text Add to dashboard Cite

Importance Inflammaging is considered a driver of age-related loss of muscle mass and function (sarcopenia). As nutrition might play a role in this process, the Dietary Inflammatory Index® (DII) has been developed to quantify the inflammatory potential of an individual diet. Objectives We aimed to examine associations between the DII, inflammation, oxidative stress and sarcopenia-related parameters in healthy old compared to young adults. Design, Setting, and Participants This cross-sectional study included data of 79 community-dwelling, healthy old adults (65–85 years) and 59 young adults (18–35 years) who participated in a randomized controlled trial from April to December 2019. Measurements The DII was computed with dietary data collected from 24-h recall interviews. Associations between the DII, inflammatory and oxidative stress markers as well as bioimpedance-derived body composition, handgrip strength and gait speed were determined with multiple linear regression analyses adjusted for age, sex, physical activity and insulin resistance. Results Regression analyses revealed significant relationships between a higher interleukin (IL) 6 and IL-6:IL-10-ratio and higher percentage fat mass (%FM), waist-to-height-ratio (WHtR) as well as lower percentage skeletal muscle mass (%SMM) and gait speed exclusively in old adults. Subsequent analyses showed that IL-6 was associated with a pro-inflammatory diet as indicated by a higher DII, again exclusively in old adults (beta coefficient (β)= 0.027, standard error (SE) 0.013, p=0.037). While the DII was not related with handgrip strength or oxidative stress in neither old nor young adults, linear models confirmed that a higher DII was inversely associated with gait speed in old participants (β= −0.022, SE 0.006, p<0.001). Finally, a pro-inflammatory diet was significantly associated with higher %FM, WHtR and lower %SMM in both age groups. Conclusion and Relevance A pro-inflammatory diet reflected by the DII is associated with higher systemic inflammation, slower gait speed as well as lower muscle mass in old adults. Intervention studies are needed to examine whether anti-inflammatory dietary approaches can help to improve muscle mass and function and thus minimize the risk for sarcopenia in the long-term.

show abstract

Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study

Cited by 18 publications

References 56 publications

Physical Activity, Inflammation, and Physical Function in Older Adults: Results From the Health & Retirement Study

Physical Activity, Inflammation, and Physical Function in Older Adults: Results From the Health & Retirement Study

A pilot study of the moderating effect of gender on the physical activity and fatigue severity among recovered COVID-19 patients

Dietary Inflammatory Index and Cross-Sectional Associations with Inflammation, Muscle Mass and Function in Healthy Old Adults

Contact Info

Product

Resources

About