Association of Exposure to Persistent Organic Pollutants With Mortality Risk

Lind, P. Monica; Salihović, Samira; Stubleski, Jordan; Kärrman, Anna; Lind, Lars

doi:10.1001/jamanetworkopen.2019.3070

Cited by 32 publications

(13 citation statements)

References 48 publications

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“…The consequences of developmental neurotoxicity in early life appear to persist across childhood and adolescence and even into adult life [ [220]. In the US NHANES survey, some organochlorine pesticides have been found to be associated with increased all-cause mortality and others with increased non-cancer, non-cardiovascular mortality [271].…”

Section: • Developmental Defectsmentioning

confidence: 99%

“…Multiple toxicological and epidemiologic studies indicate that PCBs, dioxins, PBDEs, OPs, OCs, PAHs and petroleum pollutants, can increase cardiovascular risk factors, including hypertension and atherosclerosis [ 216 217 218 219 ], and increase prevalence of cardiovascular disease, stroke, and heart failure. Powerful prospective cohort studies, such as the Nurses’ Health Study II and the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study [ 220 ] provide compelling evidence that POPs exposures in humans are associated with a broad range of cardiovascular conditions.…”

Section: Impacts Of Ocean Pollution On Human Healthmentioning

confidence: 99%

“…Mortality: Studies in the PIVUS cohort suggest that mortality due to CVD is associated with higher body burdens of POPs [ 220 ]. In the US NHANES survey, some organochlorine pesticides have been found to be associated with increased all-cause mortality and others with increased non-cancer, non-cardiovascular mortality [ 271 ].…”

Section: Impacts Of Ocean Pollution On Human Healthmentioning

confidence: 99%

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Human Health and Ocean Pollution

Landrigan

Stegeman

Fleming

et al. 2020

Annals of Global Health

366

170

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Methods: Topic-focused reviews that examine the effects of ocean pollution on human health, identify gaps in knowledge, project future trends, and offer evidence-based guidance for effective intervention. Environmental Findings: Pollution of the oceans is widespread, worsening, and in most countries poorly controlled. It is a complex mixture of toxic metals, plastics, manufactured chemicals, petroleum, urban and industrial wastes, pesticides, fertilizers, pharmaceutical chemicals, agricultural runoff, and sewage. More than 80% arises from land-based sources. It reaches the oceans through rivers, runoff, atmospheric deposition and direct discharges. It is often heaviest near the coasts and most highly concentrated along the coasts of low-and middle-income countries. Plastic is a rapidly increasing and highly visible component of ocean pollution, and an estimated 10 million metric tons of plastic waste enter the seas each year. Mercury is the metal pollutant of greatest concern in the oceans; it is released from two main sources-coal combustion and small-scale gold mining. Global spread of industrialized agriculture with increasing use of chemical fertilizer leads to extension of Harmful Algal Blooms (HABs) to previously unaffected regions. Chemical pollutants are ubiquitous and contaminate seas and marine organisms from the high Arctic to the abyssal depths. Ecosystem Findings: Ocean pollution has multiple negative impacts on marine ecosystems, and these impacts are exacerbated by global climate change. Petroleum-based pollutants reduce photosynthesis in marine microorganisms that generate oxygen. Increasing absorption of carbon dioxide into the seas causes ocean acidification, which destroys coral reefs, impairs shellfish development, dissolves calcium-containing microorganisms at the base of the marine food web, and increases the toxicity of some pollutants. Plastic pollution threatens marine mammals, fish, and seabirds and accumulates in large mid-ocean gyres. It breaks down into microplastic and nanoplastic particles containing multiple manufactured chemicals that can enter the tissues of marine organisms, including species consumed by humans. Industrial releases, runoff, and sewage increase frequency and severity of HABs, bacterial pollution, and anti-microbial resistance. Pollution and sea surface warming are triggering poleward migration of dangerous pathogens such as the Vibrio species. Industrial discharges, pharmaceutical wastes, pesticides, and sewage contribute to global declines in fish stocks. Human Health Findings: Methylmercury and PCBs are the ocean pollutants whose human health effects are best understood. Exposures of infants in utero to these pollutants through maternal consumption of contaminated seafood can damage developing brains, reduce IQ and increase children's risks for autism, ADHD and learning disorders. Adult exposures to methylmercury increase risks for cardiovascular disease and dementia. Manufactured chemicals-phthalates, bisphenol A, flame retardants, and perfluorinated chemicals...

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Section: • Developmental Defectsmentioning

confidence: 99%

Section: Impacts Of Ocean Pollution On Human Healthmentioning

confidence: 99%

Section: Impacts Of Ocean Pollution On Human Healthmentioning

confidence: 99%

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Human Health and Ocean Pollution

Landrigan

Stegeman

Fleming

et al. 2020

Annals of Global Health

366

170

View full text Add to dashboard Cite

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“…Thus, POPs have been detected in human blood, body fat and breast milk in several studies around the globe (WHO 2010a, b;Lind et al 2019).…”

Section: The Persistent Organic Chemical Pollutantsmentioning

confidence: 99%

Global Impact of Chemicals and Toxic Substances on Human Health and the Environment

Adeola¹

2020

Handbook of Global Health

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This chapter addresses the global impacts of heterogenous chemicals and toxic substances on human health and the environment. Chemicals and hazardous substances are ubiquitous in every nook and cranny of society across the globe. The challenges facing the scientific community in documenting the number and variety of chemicals, and hazardous products that are manufactured, available on the market, and in use as well as the disease burden associated with them are discussed. The chapter addresses the chemicals, hazardous substances of global public health concern, including air pollution, inorganic substances especially heavy metals, and synthetic organic compounds such as the Persistent Organic Pollutants (POPs) and pesticides. Gaseous elements, acids and bases are also covered. Major sources of releases into the environment and routes of exposure and the consequences for exposed population's health and well-being are addressed. The estimated Global Burden of Disease (GBD), Disability Adjusted Life Years (DALYs), and economic loss associated with selected chemical

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“…For example, exogenous lipophilic chemical exposures are associated with metabolic, cardiovascular and neurological disease onset in dose response relationships. [Grova, et al, 2019;Lind, et al, 2019Lee, et al, 2018] and hydrophilic exogenous chemical absorption causes numerous cancers, respiratory and neurological diseases [Yegambaram, et al, 2015;Fisseler-Eckhoff, et al, 2011;Caffo, et al, 2014]. These chemicals, which include persistent organic pollutants such as PCBs, chlorinated pesticides, polybrominated biphenyls and dioxins; phthalates; Bisphenol A; heavy metals including lead, mercury, chromium, arsenic, nickel and cadmium; polynuclear aromatic hydrocarbons; benzene, toluene, xylenes and other hydrocarbons; water chlorination by-products; air pollutants; water pollutants; and numerous others, all elevate OS [Zeliger.…”

Section: Toxic Chemical Exposurementioning

confidence: 99%

Predicting and Reducing Adverse Drug Reactions (ADRs)

Zeliger

2019

EJMED

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All pharmaceutical drugs (PDs) have Adverse drug reactions (ADRs) associated with their use in some individuals. ADRs are a leading cause of morbidity and mortality in those using (PDs). It is well known that the number and severity of ADRs associated with the use of PDs are elevated by a number of parameters including age, gender, genetic makeup, polypharmacy, exposure to organic solvents, alcohol, tobacco or recreational drug use, diet, chronic inflammation, preexisting disease and ongoing emotional stress. All the parameters responsible for ADRs also increase oxidative stress (OS) as reflected by the Oxidative Stress Index (OSI). The OSI is hypothesized here to predict the likelihood and severity of ADRs.

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Association of Exposure to Persistent Organic Pollutants With Mortality Risk

Cited by 32 publications

References 48 publications

Human Health and Ocean Pollution

Human Health and Ocean Pollution

Global Impact of Chemicals and Toxic Substances on Human Health and the Environment

Predicting and Reducing Adverse Drug Reactions (ADRs)

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