Association of exposure to particulate matter (PM2.5) air pollution and biomarkers of cardiovascular disease risk in adult NHANES participants (2001–2008)

Dabass, Arvind; Talbott, Evelyn O.; Venkat, Arvind; Rager, Judith R.; Marsh, Gary M.; Sharma, Ravi; Holguín, Fernando

doi:10.1016/j.ijheh.2015.12.002

Cited by 95 publications

(52 citation statements)

References 29 publications

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“…Because each air pollutants have high correlation (3), we also applied multi-pollutant models in the analysis; Model 1 controlled sociodemographic factors, and Model 2 controlled sociodemographic, clinical factors as covariates. Moreover, we analyzed associations between air pollution factors and the presence of pterygium with two different ways: 1) a model using average concentrations for previous 2 years before the ocular examination; and 2) distributed lag models using annual average concentrations by up to lagged 2 years before the ocular examination (year lag 0 through year lag 2), to account for the cumulative and/or delayed effects of environmental exposures (111213). Primary pterygium was also analyzed according to aforementioned statistical methods (n = 22,216).…”

Section: Methodsmentioning

confidence: 99%

Outdoor Air Pollution and Pterygium in Korea

et al. 2017

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We investigated relationships between outdoor air pollution and pterygium in Korean adults. This study includes 23,276 adults in population-based cross-sectional data using the Korea National Health and Nutrition Examination Survey 2008–2011. Pterygium was assessed using slit lamp biomicroscopy. Air pollution data (humidity, particulate matter with aerodynamic diameter less than 10 μm [PM10], ozone [O3], nitrogen dioxide [NO2], and sulfur dioxide levels [SO2]) for 2 years preceding the ocular examinations were acquired. Associations of multiple air pollutants with pterygium or pterygium recurrence after surgery were examined using multivariate logistic models, after adjusting for several covariates. Distributed lag models were additionally used for estimating cumulative effects of air pollution on pterygium. None of air pollution factors was significantly associated with pterygium or pterygium recurrence (each P > 0.05). Distributed lag models also showed that air pollution factors were not associated with pterygium or pterygium recurrence in 0-to-2 year lags (each P > 0.05). However, primary pterygium showed a weak association with PM10 after adjusting for covariates (odds ratio [OR] 1.23; [per 5 μg/m3 PM10 increase]; P = 0.023). Aging, male sex, and greater sun exposure were associated with pterygium, while higher education level and myopia were negatively associated with pterygium (each P ≤ 0.001). Male sex and myopia were negatively associated with pterygium recurrence (each P < 0.05). In conclusion, exposure to higher PM10 levels was associated with primary pterygium, although this study observed no significant association between air pollution and overall pterygium or pterygium recurrence in Korean adults.

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Section: Methodsmentioning

confidence: 99%

Outdoor Air Pollution and Pterygium in Korea

et al. 2017

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“…Accumulation of β2-microglobulin may be due to decreased removal and intra-dialytic production by the reactive inflammation by bio-incompatible artificial kidney membranes [2]. Air pollution levels, especially particulate matter with an aerodynamic diameter of <2.5 mm (PM 2.5), are significantly associated with elevation of systemic inflammatory markers [3-5]. We have previously showed that air pollution was significantly associated with arterial stiffness, systemic inflammation, infection, secondary hyperparathyroidism, and even mortality in MHD patients [6-10].…”

Section: Introductionmentioning

confidence: 99%

Association Between Environmental Particulate Matter and Carpal Tunnel Syndrome in Patients Undergoing Hemodialysis

Weng

Yen

et al. 2017

Kidney Blood Press Res

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Background/Aims: The deposition of β2-microglobulin induced by reactive inflammation causing carpal tunnel syndrome (CTS) is one of the complications of dialysis-related amyloidosis in maintenance hemodialysis (MHD) patients. Air pollution levels, especially particulate matter with an aerodynamic diameter of <2.5 mm (PM_2.5)_, have significantly been associated with the elevation of systemic inflammatory markers. There is no previous research on possible associations between CTS and PM_2.5. Methods: This study enrolled 866 MHD patients treated at the outpatient HD centers. Senior neurologists diagnosed the presence of CTS. Air pollution levels were recorded by a network of 27 monitoring stations near or in the patients’ living areas throughout Taiwan. The 12- and 24-month average concentrations of PM with an aerodynamic diameter of <10 and <2.5 mm (PM₁₀ and PM_2.5, respectively), sulfur dioxide, nitrogen dioxide, carbon monoxide, and ozone were included. Results: Multivariate logistic regression analyses showed that HD duration, the normalized protein catabolic rate (nPCR), hypoalbuminemia (albumin < 4 g/dl), and the mean previous 12-month environmental PM_2.5 were positively associated with CTS; HD duration, nPCR, hypoalbuminemia (albumin < 4 g/dl), and the mean previous 24-month environmental PM_2.5 were positively associated with CTS; HD duration, hypoalbuminemia (albumin < 4 g/dl), and previous 12-month PM_2.5 excess days were positively associated with CTS; and HD duration, nPCR, hypoalbuminemia (albumin < 4 g/dl), and previous 24-month PM_2.5 excess days were positively associated with CTS. Conclusion: PM_2.5 levels and PM_2.5 excessing days were positively correlated with CTS.

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“…Most diseases, including angiocardiopathy, are associated with acute or chronic exposure to air pollution [46-49]. The effect of atmospheric particulate matter (PM 2.5 ) on extrapulmonary organs has received attention in recent years, and considerable numbers of epidemiological studies have confirmed that PM 2.5 can increase the morbidity and mortality from cardiovascular disease and lung disease in aging populations [1]. Inhaled PM 2.5 can be deposited in the alveoli, and particles with sizes < 0.1 µm can enter the blood circulation [1].…”

Section: Discussionmentioning

confidence: 99%

“…The effect of atmospheric particulate matter (PM 2.5 ) on extrapulmonary organs has received attention in recent years, and considerable numbers of epidemiological studies have confirmed that PM 2.5 can increase the morbidity and mortality from cardiovascular disease and lung disease in aging populations [1]. Inhaled PM 2.5 can be deposited in the alveoli, and particles with sizes < 0.1 µm can enter the blood circulation [1]. The human health hazards of atmospheric PM 2.5 are closely associated with the particulate characteristics and pollution levels.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary Exposure to Particulate Matter (PM2.5) Affects the Sensitivity to Myocardial Ischemia/Reperfusion Injury Through Farnesoid-X-Receptor-Induced Autophagy

Tong¹,

Zhang²

2018

Cell Physiol Biochem

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Background/Aims: The purpose of this study was to investigate the effect of administering particulate matter (PM_2.5) to the lungs on the sensitivity to myocardial ischemia/reperfusion injury (MI/RI) and the role of farnesoid-X-receptor (FXR)-induced autophagy in this process. Methods: Male Sprague Dawley (SD) rats were subjected to 45 min of ischemia, and the lungs were exposed to 2.0 mg of PM_2.5 in 0.3 mL of normal saline 5 min before reperfusion. After 24 h of reperfusion, the blood and myocardium were collected, and the myocardial infarct sizes, activities of serum creatine kinase (CK) and lactate dehydrogenase (LDH), and levels of serum high sensitivity C-reactive protein (hsCRP), interleukin-4 (IL-4), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), cardiac troponin T (cTnT), P-selectin and D-dimer were measured via biochemical analysis. Additionally, the myeloperoxidase (MDA) content and superoxide dismutase (SOD) activity were measured in myocardial tissues via biochemical analysis, and the levels of reactive oxygen species (ROS), autophagosomes, microtubule-associated protein 1 light chain 3 (LC-I and II), macrophage inflammatory protein-2 (MIP-2) and farnesoid-X-receptor (FXR) were determined in myocardial tissues via biochemical analysis, immunohistochemical and biochemical techniques and western blot. In addition, the myocardial infarct sizes, LC-I and II expressions were determined in myocardial tissues through FXR^-/- and WT mice. Results: Levels of CK, LDH, hsCRP, IL-6, TNF-α, cTnT, P-selectin and D-dimer, MDA and infarct sizes were higher in I/R group than that in Sham group, and Levels of IL-4 and SOD were lower in I/R group than that in Sham group; ROS, autophagosomes, LC-3I, LC-3II, MIP-2 and FXR expressions were higher in I/R group than that in Sham group. Levels of CK, LDH, hsCRP, IL-6, TNF-α, cTnT, P-selectin and D-dimer, MDA and infarct sizes were higher in PM_2.5 group than that in I/R group, and Levels of IL-4 and SOD were lower in PM_2.5 group than that in I/R group; ROS, autophagosomes, LC-3I, LC-3II, MIP-2 and FXR expressions were higher in PM_2.5 group than that in I/R group. Conclusions: PM_2.5 post-treatment exacerbated myocardial injury partly through upregulation of FXR to induce autophagy compared to MI/RI.

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Association of exposure to particulate matter (PM2.5) air pollution and biomarkers of cardiovascular disease risk in adult NHANES participants (2001–2008)

Cited by 95 publications

References 29 publications

Outdoor Air Pollution and Pterygium in Korea

Outdoor Air Pollution and Pterygium in Korea

Association Between Environmental Particulate Matter and Carpal Tunnel Syndrome in Patients Undergoing Hemodialysis

Pulmonary Exposure to Particulate Matter (PM2.5) Affects the Sensitivity to Myocardial Ischemia/Reperfusion Injury Through Farnesoid-X-Receptor-Induced Autophagy

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