Association of Depression With All-Cause and Cardiovascular Disease Mortality Among Adults in China

Wang, Mengqi; Yu, Canqing; Liu, Na; He, Meian; Lv, Jun; Guo, Yu; Zheng, Bin; Yang, Ling; Chen, Yiping; Zhang, Xiaomin; Chen, Zhengming; Wu, Tangchun; Pan, An; Li, Liming

doi:10.1001/jamanetworkopen.2019.21043

Cited by 154 publications

(76 citation statements)

References 49 publications

(99 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the Japanese cohort, Yamada and colleagues reported a twofold higher risk of death from ischemic stroke in a young subgroup of participants (aged 40-59) who experienced two or more pregnancy losses than those with no history of pregnancy loss 15. Recurrent spontaneous abortion is a major stressful event in a woman’s life and has been associated with adverse mental health problems, such as depression and anxiety after the loss,42 which are increasingly known as potential risk factors for all cause mortality and mortality related to cardiovascular disease 43. The association between spontaneous abortion and all cause premature mortality was also stronger in women who experienced their first spontaneous abortion early in their reproductive life, suggesting that spontaneous abortion at an older age is more likely an indication of age related changes, such as chromosomal abnormalities and decreased ovarian function,4445 rather than an early sign of underlying physiopathology resulting in a greater risk of premature death.…”

Section: Discussionmentioning

confidence: 99%

Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study

Wang

Mínguez-Alarcón

Gaskins

et al. 2021

BMJ

Self Cite

View full text Add to dashboard Cite

Objective To investigate the association of spontaneous abortion with the risk of all cause and cause specific premature mortality (death before the age of 70). Design Prospective cohort study. Setting The Nurses’ Health Study II (1993-2017), United States. Participants 101 681 ever gravid female nurses participating in the Nurses’ Health Study II. Main outcomes measures Lifetime occurrence of spontaneous abortion in pregnancies lasting less than 6 months, determined by biennial questionnaires. Hazard ratios and 95% confidence intervals for all cause and cause specific premature death according to the occurrence of spontaneous abortion, estimated with time dependent Cox proportional hazards models. Results During 24 years of follow-up, 2936 premature deaths were recorded, including 1346 deaths from cancer and 269 from cardiovascular disease. Crude all cause mortality rates were comparable for women with and without a history of spontaneous abortion (1.24 per 1000 person years in both groups) but were higher for women experiencing three or more spontaneous abortions (1.47 per 1000 person years) and for women reporting their first spontaneous abortion before the age of 24 (1.69 per 1000 person years). The corresponding age adjusted hazard ratios for all cause premature death during follow-up were 1.02 (95% confidence interval 0.94 to 1.11), 1.39 (1.03 to 1.86), and 1.27 (1.11 to 1.46), respectively. After adjusting for confounding factors and updated dietary and lifestyle factors, the occurrence of spontaneous abortion was associated with a hazard ratio of 1.19 (95% confidence interval 1.08 to 1.30) for premature mortality during follow-up. The association was stronger for recurrent spontaneous abortions (hazard ratio 1.59, 95% confidence interval 1.17 to 2.15 for three or more spontaneous abortions; 1.23, 1.00 to 1.50 for two; and 1.16, 1.05 to 1.28 for one compared with none), and for spontaneous abortions occurring early in a woman’s reproductive life (1.32, 1.14 to 1.53 for age ≤23; 1.16, 1.01 to 1.33 for ages 24-29; and 1.12, 0.98 to 1.28 for age ≥30 compared with none). When cause specific mortality was evaluated, the association of spontaneous abortion with premature death was strongest for deaths from cardiovascular disease (1.48, 1.09 to 1.99). Spontaneous abortion was not related to premature death from cancer (1.08, 0.94 to 1.24). Conclusions Spontaneous abortion was associated with an increased risk of premature mortality, particularly death from cardiovascular disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study

Wang

Mínguez-Alarcón

Gaskins

et al. 2021

BMJ

Self Cite

View full text Add to dashboard Cite

show abstract

“…5 Data indicated that depressive symptoms are correlated with an increased prevalence of cardiovascular diseases and allcause mortality in Chinese adults. 6 In China, the lifetime prevalence of depression was 6.9%, the prevalence of depression was higher in female, and those individuals with aged 18-34 years had a higher prevalence of depression than adults aged 35-49 years. 1 However, a metaanalysis showed that the incidence rate of depressive symptoms was 23.8% among 32,694 Chinese university students from 1997 to 2015.…”

Section: Introductionmentioning

confidence: 97%

<p>Intensity of Physical Activity and Depressive Symptoms in College Students: Fitness Improvement Tactics in Youth (FITYou) Project</p>

Guo

Tian

Zhong

et al. 2020

PRBM

View full text Add to dashboard Cite

To investigate whether the physical activity at different intensities is correlated with depressive symptoms in college students. Patient and Methods: This cross-sectional study was a part of the Fitness Improvement Tactics in Youth Project, which was conducted in 2017. A total of 2,820 college freshmen aged 15-24 years were included in this study, of whom 699 (24.8%) were males and 2,121 (75.2%) were females. Depressive symptoms were measured using the Self-rating Depression Scale. Physical activity was assessed using the International Physical Activity Questionnaire-Short Form. Covariates included sociodemographic, lifestyle-related, and health-related factors. Results: A total of 560 (19.9%) college students had depressive symptoms. Total physical activity levels (METs•hour/week) were positively associated with frequency of breakfast intake (p = 0.050) but no other participant characteristics. Logistic regression analysis showed that the prevalence of depressive symptoms in the highest quartile of physical activity was lower than in the lowest quartile when adjusted for sex, age, ethnicity, only child, smoking status, alcohol use, breakfast frequency, daily sleep duration, body mass index, grip strength, and the number of metabolic syndrome components (odds ratios [95% confidence intervals (CI)]: 0.75 [0.58, 0.98], p = 0.036). Furthermore, high physical activity levels of low-intensity tended to moderately correlate to lower prevalence of depressive symptoms (odds ratios [95% CI]: Q1, 0.71 [0.55, 0.91], Q2, 0.77 [0.59, 1.01], Q3, 0.75 [0.57, 0.98], p for trend = 0.037). Associations of moderate and vigorous physical activity with depressive symptoms were not found. For secondary outcomes, sex-stratified analysis showed that similar findings were only found in females, but not males. Conclusion: This study indicated that total physical activity and low-intensity physical activity were inversely associated with depressive symptoms in Chinese college students. All these observations showed gender differences.

show abstract

“…Moreover, even if they were not infected with COVID-19, patients in long-term care settings had to be abruptly isolated, losing contact with families and caregivers. Such a situation may have led to depression and a decline in their psychological and physical health [23]. Solutions targeting these specific issues and ways to improve the community health training of long-term care personnel and administrators should be investigated in the future.…”

Section: Discussionmentioning

confidence: 99%

Health and Healthcare Variables Associated with Italy’s Excess Mortality during the First Wave of the COVID-19 pandemic: An Ecological Study

Buja¹,

Paganini

Fusinato

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundHealthcare factors have strongly influenced the propagation of COVID-19. The present study aims to examine whether excess mortality during the first phase of the COVID-19 outbreak in Italy was associated with health, healthcare, demographic, and socioeconomic indicators measured at a provincial level.MethodsThe present ecological study concerns the raw number of deaths from Jan. 1 to Apr. 30, 2020 and the mean number of deaths in the same months of 2015 to 2019, per province. Information on socioeconomic factors and healthcare settings were extracted from the most recently updated databases on the ISTAT website. Two multilevel, multivariate models were constructed to test whether excess mortality was associated with the indicators across 107 provinces in Italy.ResultsOn linear multilevel, multivariate analysis, AIDS mortality rate (p-value <0.05) correlates positively with excess mortality, while a higher density of General Practitioners (number of GPs per 1,000 population) is associated with lower excess mortality (p-value <0.05). After controlling for the diffusion of COVID-19 in each province, the significance of GP density increases (p-value <0.001) and the rate of hospitalization in long-term care wards is positively associated (p-value <0.05) with excess mortality.ConclusionSome health and healthcare variables are strongly associated with excess mortality caused by COVID-19 in Italy and should be considered to implement mitigation policies and increase healthcare resilience.

show abstract

Association of Depression With All-Cause and Cardiovascular Disease Mortality Among Adults in China

Abstract: IMPORTANCE Depression is associated with increased disease burden worldwide and with higher risk of mortality in Western populations. OBJECTIVE To investigate whether depression is a risk factor for all-cause and cardiovascular disease (CVD) mortality in adults in China.

Cited by 154 publications

References 49 publications

Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study

Association of spontaneous abortion with all cause and cause specific premature mortality: prospective cohort study

<p>Intensity of Physical Activity and Depressive Symptoms in College Students: Fitness Improvement Tactics in Youth (FITYou) Project</p>

Health and Healthcare Variables Associated with Italy’s Excess Mortality during the First Wave of the COVID-19 pandemic: An Ecological Study

Contact Info

Product

Resources

About