Association of cyclin D1 gene polymorphisms with risk of esophageal squamous cell carcinoma in Kashmir Valley—A high risk area

Hussain, Showket; Yuvaraj, M; Thakur, Nisha; Salam, Irfana; Singh, Neha; Mir, Mohammad Muzaffar; Bhat, Mohammad Akbar; Siddiqi, Mushtaq A.; Das, Bina Pani; Bharadwaj, Mausumi

doi:10.1002/mc.20732

Cited by 21 publications

(24 citation statements)

References 56 publications

(73 reference statements)

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“…If more than 1 geographical or ethnic group was included in the same study, then data from different populations were extracted. Therefore, 8 studies, including 9 populations (Yu et al, 2003;Zhang et al, 2003;Casson et al, 2005;Geddert et al, 2005;Jain et al, 2007;Akbari et al, 2009;Liu et al, 2010;Hussain et al, 2011) with 1898 patients with esophageal cancer and 3046 controls were finally identified: 4 populations were from East Asia [2 Chinese (Yu et al, 2003;Zhang et al, 2003) and 2 from India (Jain et al, 2007;Hussain et al, 2011)], 2 were from West Asia (Akbari et al, 2009), and 3 included Caucasians (Casson et al, 2005;Geddert et al, 2005;Liu et al, 2010). A flow diagram schematizing the process of selected and excluded articles with specific reasons for each is presented in Figure 1.…”

Section: Baseline Characteristicsmentioning

confidence: 99%

“…A flow diagram schematizing the process of selected and excluded articles with specific reasons for each is presented in Figure 1. With regard to the study design, 3 of these studies were population based (Yu et al, 2003;Zhang et al, 2003;Akbari et al, 2009), and 5 employed a hospital-based design (Casson et al, 2005;Geddert et al, 2005;Jain et al, 2007;Liu et al, 2010;Hussain et al, 2011 …”

Section: Baseline Characteristicsmentioning

confidence: 99%

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Lack of association between Cyclin D1 gene G870A polymorphism and esophageal cancer: evidence from a meta-analysis

Cai

Wang²,

Zhong³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. The association between the Cyclin D1 gene (CCND1) G870A polymorphism and esophageal cancer has been widely evaluated, with conflicting results. As meta-analysis is a reliable approach to resolving discrepancies, we aimed to evaluate this association. Data were available from 9 study populations incorporating 1898 cases and 3046 controls. Overall, the allelic/genotypic association between the G870A polymorphism and esophageal cancer was nonsignificant [for allele: odds ratio (OR) = 1.14, 95% confidence interval (95%CI) = 0.94-1.38, P = 0.184; for genotype homozygous comparison: OR = 1.36, 95%CI = 0.90-2.06, P = 0.140; for dominant model: OR = 1.24, 95%CI = 0.88-1.75, P = 0.222; for recessive model: OR = 1.13, 95%CI = 0.90-1.43, P = 0.292]. Moreover, subgroup analyses according to study designs, geographic areas, types of esophageal cancer, genotyping methods, and ethnicities failed to demonstrate a significant association between this polymorphism and esophageal cancer. In addition, there was significant publication bias as reflected by funnel plots and the 6637 CCND1 G870A and esophageal cancer ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (4): 6636-6645 (2013) Egger test (P = 0.042). Taken together, our results suggest that the CCND1 G870A polymorphism might not be a potential candidate for predicting esophageal cancer risk.

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Section: Baseline Characteristicsmentioning

confidence: 99%

Section: Baseline Characteristicsmentioning

confidence: 99%

Lack of association between Cyclin D1 gene G870A polymorphism and esophageal cancer: evidence from a meta-analysis

Cai

Wang²,

Zhong³

et al. 2013

Genet. Mol. Res.

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“…An age-standardized incidence rate of 4.52 per 100,000 of population has been reported for this disease. Recent times have observed a remarkable progress in terms of the pace with which molecular studies including the polymorphic and mutational analysis have been carried on different GIT cancers in the valley that has given an insight about the predominance of variants present in our unique ethnic race (Hussain et al, 2011;Javid et al, 2011;Malik et al, 2011a;2011b;2011c;Rasool et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

Rasool

Kadla²,

Khan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Roles of the vitamin D receptor in etiology of cancers, including colorectal cancer, have been repeatedly stressed in different parts of the world. A case control study aimed to evaluate the relationship between the two was therefore initiated in Kashmir, known both for its increasing incidence of gastrointestinal cancers and deficiency of micro-nutrients especially vitamin D. The study included a total of 617 subjects (312 colorectal cancer cases and 305 controls), with sampling carried out over a period of 5 years. DNA samples from the blood of the subjects were analyzed for start codon Fok I VDR polymorphism. We obtained a 1.3 fold increased risk among individuals homozygous for f variants as compared to subjects homozygous for F allele (odds ratio OR 1.3, 95%CI, 0.861-1.65). Our study also showed statistically significant results when dwelling and tumor location characteristics were stratified with Fok I polymorphism, all of which suggests a possible role of Fok I polymorphism in the etiology of CRC in Kashmir

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“…Casson et al (15), Jain et al (17) and Hussain et al (19) showed a significant association between this polymorphism and esophageal cancer. However, four other studies demonstrated no significant association between this polymorphism and esophageal cancer (13,14,16,18).…”

Section: Resultsmentioning

confidence: 95%

“…The full text of these articles was reviewed intensively and three articles without the control group were excluded. Thus, seven case-control studies (1,154 esophageal cancer cases and 1,678 controls) on the association between CCND1 G870 polymorphism and esophageal cancer risk were included in this meta-analysis (13)(14)(15)(16)(17)(18)(19). Of these included articles, four studies were on Caucasians (15,16,18,19) and three studies were on Asians (13,14,17).…”

Section: Resultsmentioning

confidence: 99%

Genetic polymorphism of CCND1 G870A and esophageal cancer susceptibility: A meta-analysis

Zeng

Long

et al. 2012

Biomedical Reports

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Abstract. The association between the polymorphism of cyclin D1 (CCND1) and esophageal carcinogenicity has been widely examined, however, it remains controversial. To evaluate the importance of CCND1 G870A polymorphism with regard to the risk of esophageal cancer, a meta-analysis was carried out that reviewed the available literature in order to clarify the controversies. This meta-analysis included 1,154 cases and 1,678 controls for CCND1 G870A polymorphism from seven published case-control studies. The odds ratio (OR) and 95% confidence interval (CI) were calculated using the Stata software version 11.1. The results were pooled using a dominant model to appropriately reflect a biological model of the genetic effect. No significant association was observed in the Caucasian (OR=1.64; 95% CI, 0.84-3.20) or the Asian populations (OR=1.30; 95% CI, 0.65-2.62), while no significant association was found in esophageal squamous cell carcinoma (ESCC) (OR=1.74; 95% CI, 0.79-3.81) or esophageal adenocarcinoma (EADC) (OR=1.18; 95% CI, 0.77-1.81). However, the comparison of A vs. G in CCND1 G870A showed significant differential susceptibility to esophageal cancer (OR=1.26; 95% CI, 1.00-1.59). These findings suggested that the CCND1 G870A polymorphism has no association with esophageal cancer risk in ethnicity and histology, respectively. Further studies are required to assess these associations in greater detail. IntroductionEsophageal cancer is a global health problem that ranked eighth in terms of incidence and sixth in terms of mortality in 2002 (1). Esophageal tumors usually lead to dysphagia, pain and other symptoms and are diagnosed via a biopsy. Esophageal cancer is divided into squamous cell carcinoma and adenocarcinoma. Squamous cell carcinoma arises from the cells that line the upper part of the esophagus. Adenocarcinoma arises from glandular cells that are present at the junction of the esophagus and stomach (2). Genetic as well as environmental factors play a role in the carcinogenesis of esophageal cancer (3,4). Individual variations in cancer risk have been associated with specific polymorphisms of various genes that are present in a significant proportion of the normal population.Cyclin D1 (CCND1) is a mitogenic sensor for the cell cycle mechanism and cellular oncogene (5). High activity of cyclin D1 can lead to chemoresistance due to the dual roles of cyclin D1 in promoting cell proliferation and inhibiting drug-induced apoptosis (6). Overexpression of cyclin D1 contributes to immature cell passage through the G1-S transition, induces propagation of unrepaired DNA damage and the accumulation of genetic errors and a selective growth advantage for the altered cells (7). Cyclin D1 are important regulators of the cell cycle and apoptosis and each contains functional single nucleotide polymorphisms (SNPs) (CCND1 G870A) that are involved in the susceptibility and outcome of various human malignancies (8).Poor statistical power has been controversial for data from individually published studies. The aim of this stu...

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Association of cyclin D1 gene polymorphisms with risk of esophageal squamous cell carcinoma in Kashmir Valley—A high risk area

Cited by 21 publications

References 56 publications

Lack of association between Cyclin D1 gene G870A polymorphism and esophageal cancer: evidence from a meta-analysis

Lack of association between Cyclin D1 gene G870A polymorphism and esophageal cancer: evidence from a meta-analysis

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

Genetic polymorphism of CCND1 G870A and esophageal cancer susceptibility: A meta-analysis

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