Association of creatine kinase and its isoenzymes (CK-MB, CK-BB) activity with high risk pregnancy

Objective of the studyTo evaluate the value of serum creatine phosphokinase-brain specific (CK-BB) and urinary lactate/creatinine (L/C) ratio as early indicators of brain damage in full-term newborns with hypoxic ischemic encephalopathy (HIE).Patients and methodsA case–control study including 25 full-term new-born infants with perinatal asphyxia who were admitted to neonatal intensive care unit (NICU) with a proven diagnosis of HIE, compared to 20 healthy age- and sex-matched full-term newborns. All newborn infants were subjected to full history taking, clinical examination, routine investigations (cord blood gases and complete blood picture), and assessment of serum CK-BB (cord blood, 6 and 24 hours after birth) and urinary L/C ratio (collected within the first 6 hours, on the 2nd and 3rd day after birth).ResultsThe serum CK-BB and urinary L/C ratio in infants with HIE were significantly higher in samples collected throughout the monitoring period when compared with the control group (all P<0.001). The cord CK-BB and urinary L/C ratio within the first 6 hours were significantly higher in infants with severe HIE than in infants with mild and moderate HIE (P<0.001). Cord CK-BB level at 12.5 U/L had 100% sensitivity and 84% specificity in the detection of severe HIE infants. Urinary L/C ratio of more than 10.5 collected within the first 6 hours after birth had 100% sensitivity and 78% specificity for the detection of severe HIE infants.ConclusionThe serum CK-BB and urinary L/C ratio in HIE infants were significantly increased early in the course of the disease, which can be used as useful indicators for predicting the development of HIE.

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“…36 The serum CK-BB in full-term newborns with high-risk pregnancy was higher in comparison with babies with normal pregnancy. 37 …”

Section: Discussionmentioning

confidence: 99%

Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy

Alkholy

Abdalmonem

Zaki

et al. 2017

NDT

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“…Total CK activity was observed independent while CK-MB and CK-BB were found dependent on different risk factors like pregnancy induced hypertension and fetal distress. Our study revealed that high risk pregnancies are associated with increased total CK, CK-MB as well as CK-BB activity (81). CONCLUSION Creatine kinase (CK) is a key enzyme of energy metabolism, especially in muscle tissue.…”

Section: E J M Rmentioning

confidence: 75%

Total Creatine Kinase and Its Isoenzymes in Cord Blood of Full Term Newborns

Khan¹,

Rathore²

2017

EJMR

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Creatine kinase (CK) is a key enzyme of energy metabolism, especially in muscle tissue. CK has two polypeptide chains of M and B, and three isomers, CK-BB, CK-MB and CK-MM. In some conditions like acute myocardial infarction and Neuromuscular disorders, increased CK activity is used as a part of diagnosis. CK can also be elevated in absence of neuromuscular diseases or cardiac injury, such as strenuous exercise, intramuscular injections etc.Several reports indicate elevated activity of serum CK in the maternal blood during child birth.

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“…Additionally, studies have observed a significant elevation in creatine kinase activity during the peripartum period [5]. Anoither recent study has even demonstrated an association between high-risk pregnancies and an increase in total CK-MB levels [6]. Therefore, given these findings, it is plausible to hypothesize that CK-MB levels may be related to adverse pregnancy outcomes, and it may help identify potential biomarkers for risk stratification and early detection of complications during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Creatine kinase-MB Levels and Gestational Duration: A Retrospective Investigation in Patients afflicted with Pulmonary Arterial Hypertension owing to congenital heart disease

Zhao,

Yang,

Zhou

et al. 2023

Preprint

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OBJECTIVE: Pulmonary arterial hypertension (PAH) presents a complex cardiopulmonary dysfunction that exerts diverse effects on physiological processes, including pregnancy outcomes. This research seeks to explore the correlation between creatine kinase-MB (CK-MB) and the gestational duration in patients afflicted with pulmonary arterial hypertension. METHODS: A retrospective analysis was conducted on a cohort of patients with pregnancy complicated by pulmonary arterial hypertension. Thorough review of the patients' medical records and laboratory data were collected. Univariate and multivariate regression analyses were employed to scrutinize the relationship between CK-MB and gestational duration. Adjustments were made for various confounding factors, and cut-off points were determined through curve fitting and threshold effect analysis. RESULTS: In individuals with pulmonary arterial hypertension (PAH) due to congenital heart disease, maternal serum CK-MB levels exhibited a significant association with gestational duration. The regression coefficient was -1.69, with a 95% confidence interval ranging from -2.86 to -0.52, indicating a statistically significant finding (P < 0.01). Moreover, the curve displayed a tangential point at 22.8 U/L. Further stratified analyses reveal significant correlations between maternal serum CK-MB levels and gestational length within specific subgroups (patients with a pulmonary arterial diameter exceeding 25 mm, patients aged higher than 30 years, and multiparous patients). CONCLUSION: The findings of this study suggest that heightened CK-MB levels are linked to shorter pregnancy duration in patients with pulmonary arterial hypertension owing to congenital heart disease, particularly those with a pulmonary arterial diameter exceeding 25 mm, multiparous individuals, or those aged below 30 years.

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Association of creatine kinase and its isoenzymes (CK-MB, CK-BB) activity with high risk pregnancy

Cited by 4 publications

References 13 publications

Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy

Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy

Total Creatine Kinase and Its Isoenzymes in Cord Blood of Full Term Newborns

The Association Between Creatine kinase-MB Levels and Gestational Duration: A Retrospective Investigation in Patients afflicted with Pulmonary Arterial Hypertension owing to congenital heart disease

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