Total Creatine Kinase and Its Isoenzymes in Cord Blood of Full Term Newborns

Abstract

Creatine kinase (CK) is a key enzyme of energy metabolism, especially in muscle tissue. CK has two polypeptide chains of M and B, and three isomers, CK-BB, CK-MB and CK-MM. In some conditions like acute myocardial infarction and Neuromuscular disorders, increased CK activity is used as a part of diagnosis. CK can also be elevated in absence of neuromuscular diseases or cardiac injury, such as strenuous exercise, intramuscular injections etc.Several reports indicate elevated activity of serum CK in the maternal blood during child birth.

Evaluation of Cesarean Section Scar Using Maternal Serum Level of Creatine Kinase Isoenzyme (Ck-Mb) Prior to Delivery

“…The CK activity tends to reach at normal levels within six-weeks after delivery. Similar trends were observed for the CK isoenzymes CKMB activity, there is significant association between serum CKMB activity and route of delivery [12,5] . Also, did not matches Leiserowitz and his coworkers who conducted his study on forty-nine normal pregnant women recruited late in the third trimester for serial determinations of creatine kinase (CK) and its MB isoenzyme fraction (CK-MB) at four different times; on recruitment between 36 and 40 weeks gestation, on admission in active labor, immediately after delivery and on the first postpartum day.…”

“…Creatine Kinase can also be elevated in absence of neuromuscular diseases or cardiac injury, CK and its isoenzyme activity show a great variation during pregnancy. Similar trends were observed for the CK isoenzymes CK-MB [5] .…”

“…CK-MB fraction was also significantly elevated at time 4 compared with times 1, 2 and 3 (P value < 0.0001). In 35.7% of the patients at time 4, CK-MB was sufficiently elevated to give the laboratory interpretation of "borderline" or "consistent with a myocardial infarction," even though none of the patients had cardiac symptoms or complications [5] , But this not matches Torabi and coworkers: who found lower CK-MB in cesarean section than NVD.CK-MB isoenzymes levels in newborns delivered vaginally were higher than elective cesarean section. This may be CKMB were taken from neonates serum not from the mothers so it did not match our theory [18] .…”

Role of Doppler ultrasound and Creatine Kinase as a Biochemical Marker in Diagnosis of Placenta Accreta

“…Table (4) indicates that there may be critical build over rate about blood transfusion around the individuals with cushion (12 patients crazy about 31) (p < 0. 001), extra surgical methods Concerning illustration bladder repair shed might have been necessary over 3 patients, uterine What's more internal iliac veins ligation, manual evacuation for placenta and square sutures required Previously, oe tolerant.…”

“…CK catalyses those transformation about creatine What's more uses adenosine triphosphate (ATP) with make phosphocreatine (PCr) and adenosine diphosphate (ADP). This CK catalyst response is reversible What's more Along these lines atp might a chance to be created starting with PCr Furthermore ADP [4].…”