The Association Between Creatine kinase-MB Levels and Gestational Duration: A Retrospective Investigation in Patients afflicted with Pulmonary Arterial Hypertension owing to congenital heart disease

Abstract

OBJECTIVE: Pulmonary arterial hypertension (PAH) presents a complex cardiopulmonary dysfunction that exerts diverse effects on physiological processes, including pregnancy outcomes. This research seeks to explore the correlation between creatine kinase-MB (CK-MB) and the gestational duration in patients afflicted with pulmonary arterial hypertension. METHODS: A retrospective analysis was conducted on a cohort of patients with pregnancy complicated by pulmonary arterial hypertension. Thorough review of the patients' medical records and laboratory data were collected. Univariate and multivariate regression analyses were employed to scrutinize the relationship between CK-MB and gestational duration. Adjustments were made for various confounding factors, and cut-off points were determined through curve fitting and threshold effect analysis. RESULTS: In individuals with pulmonary arterial hypertension (PAH) due to congenital heart disease, maternal serum CK-MB levels exhibited a significant association with gestational duration. The regression coefficient was -1.69, with a 95% confidence interval ranging from -2.86 to -0.52, indicating a statistically significant finding (P < 0.01). Moreover, the curve displayed a tangential point at 22.8 U/L. Further stratified analyses reveal significant correlations between maternal serum CK-MB levels and gestational length within specific subgroups (patients with a pulmonary arterial diameter exceeding 25 mm, patients aged higher than 30 years, and multiparous patients). CONCLUSION: The findings of this study suggest that heightened CK-MB levels are linked to shorter pregnancy duration in patients with pulmonary arterial hypertension owing to congenital heart disease, particularly those with a pulmonary arterial diameter exceeding 25 mm, multiparous individuals, or those aged below 30 years.