Association of childhood adiposity measures with adulthood knee cartilage defects and bone marrow lesions: a 25-year cohort study

Meng, Tao; Thayer, Sydney M.; Venn, Alison; Wu, Feitong; Cicuttini, Flavia Maria; March, Lyn; Dwyer, Terence; Halliday, Andrew; Cross, Marita; Laslett, Laura L; Jones, Graeme; Ding, Changhai; Antony, Benny

doi:10.1016/j.joca.2018.05.008

Cited by 8 publications

(3 citation statements)

References 53 publications

(39 reference statements)

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“…One study also investigated the effects of childhood obesity on knee structural pathology in adult life. Meng et al evaluated 327 subjects from the Australian Schools Health and Fitness Survey (ASHFS) and found that childhood obesity was associated with an increased risk of adulthood patellar cartilage defects and patellar bone marrow edema lesions on MRI 8 .…”

Section: Obesity In Knee Oamentioning

confidence: 99%

Osteoarthritis year in review 2019: imaging

Kijowski

Demehri

Roemer

et al. 2020

Osteoarthritis and Cartilage

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PET-MRI". Articles were reviewed to determine relevance based upon the following criteria: 1) study involved human subjects with OA or risk factors for OA and 2) study involved imaging to evaluate OA disease status or OA treatment response. Relevant articles were ranked according to scientific merit, with the best publications selected for inclusion in the narrative report. Results: The PubMed search revealed a total of 1257 articles, of which 256 (20.4%) were considered relevant to OA imaging. Two-hundred twenty-six (87.1%) articles involved the knee joint, while 195 (76.2%) articles involved the use of magnetic resonance imaging (MRI). The proportion of published studies involving the use of MRI was higher than previous years. An increasing number of articles were also published on imaging of subjects with joint injury and on deep learning application in OA imaging. Conclusion: MRI and other imaging modalities continue to play an important role in research studies designed to better understand the pathogenesis, progression, and treatment of OA.

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Section: Obesity In Knee Oamentioning

confidence: 99%

Osteoarthritis year in review 2019: imaging

Kijowski

Demehri

Roemer

et al. 2020

Osteoarthritis and Cartilage

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“…Knees were imaged on a 1.5 T whole-body magnetic resonance unit with use of a commercial transmit-receive extremity coil. The Knee cartilage defects were measured as previously reported [22] in an ordinal scale using the T1-weighted spoiled gradient-recalled sagittal MR images and proton density-weighted fast spin-echo coronal MR images together. Grade 0 indicated a normal cartilage.…”

Section: Mri Measurementsmentioning

confidence: 99%

Association of glucose homeostasis and metabolic syndrome with knee cartilage defects and cartilage volume in young adults

Meng

Antony

Venn

et al. 2020

Seminars in Arthritis and Rheumatism

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“…However, most of these studies have focussed on the association between obesity and OA in adults, and little is known about the risk of obesity and OA in childhood. Observational studies have shown that childhood obesity is associated with knee joint pain, stiffness, and dysfunction in adulthood [ 11 , 12 ]. However, those studies could be affected by confounders, such as health and nutritional status, which could result in a potential relationship of reverse causality.…”

Section: Introductionmentioning

confidence: 99%

A causal relationship between childhood obesity and risk of osteoarthritis: results from a two-sample Mendelian randomization analysis

Cao

et al. 2022

Annals of Medicine

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Purpose It has been found that childhood obesity (CO) may play an important role in the onset and progression of osteoarthritis (OA). Thus we conducted this mendelian randomisation analysis (MR) to evaluate the causal association between childhood obesity and osteoarthritis. Methods Instrumental variables (IVs) were obtained from publicly available genome-wide association study datasets. The leave-one-out sensitivity test, MR Pleiotropy RESidual Sum and Outlier test (MR-PRESSO), and Cochran’s Q test were used to confirm the heterogeneity and pleiotropy of identified IVs, then five different models, including the inverse variance weighted model (IVW), weighted median estimator model (WME), weighted model-based method (WM), MR-Egger regression model (MER), and MR-Robust Adjusted Profile Score (MRAPS) were applied in this MR analysis. Results After excluding all outliers identified by the MR-PRESSO test, no evident directional pleiotropy was found. Significant heterogeneity was found in the secondary MR and as a result, the multiplicative random-effect model was used. Significant causal association between CO and OA (OR 1.0075, 95% CI [1.0054, 1.0010], p = 8.12 × 10 −13 ). The secondary MR also revealed that CO was causally associated with knee OA (OR 1.1067, 95% CI [1.0769, 1.1373], p = 3.30 × 10 −13 ) and hip OA (OR 1.1272, 95% CI [1.0610, 1.1976], p = 1.07 × 10 −4 ). The accuracy and robustness of these findings were confirmed by sensitivity tests. Conclusion There appears to be a causal relationship between childhood obesity and OA. Our results indicate that individuals with a history of childhood obesity require specific clinical attention to prevent the development of knee and hip OA.

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Association of childhood adiposity measures with adulthood knee cartilage defects and bone marrow lesions: a 25-year cohort study

Cited by 8 publications

References 53 publications

Osteoarthritis year in review 2019: imaging

Osteoarthritis year in review 2019: imaging

Association of glucose homeostasis and metabolic syndrome with knee cartilage defects and cartilage volume in young adults

A causal relationship between childhood obesity and risk of osteoarthritis: results from a two-sample Mendelian randomization analysis

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