Association of glucose homeostasis and metabolic syndrome with knee cartilage defects and cartilage volume in young adults

Meng, Tao; Antony, Benny; Venn, Alison; Fraser, Brooklyn J.; Cicuttini, Flavia Maria; March, Lyn; Cross, Marita; Dwyer, Terence; Jones, Graeme; Laslett, Laura L; Ding, Changhai

doi:10.1016/j.semarthrit.2019.10.001

Cited by 3 publications

(2 citation statements)

References 31 publications

(32 reference statements)

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“…Of all the above-mentioned bioactive compounds, several studies have appointed CGAs as some of the major responsible for the positive modulation of coffee on glucose metabolism, particularly (but not only) due to their ability to inhibit intestinal glucose transporters [ 6 , 7 , 8 , 9 ]. The maintenance of glucose homeostasis is, indeed, of crucial importance to human physiology, and the dysregulation of this mechanism is known to be on the basis of metabolic syndrome (MetS) development [ 10 ]. MetS consists of a set of interconnected biochemical, metabolic, and clinical factors, increasing susceptibility to illnesses such as DM2, non-alcoholic fatty liver disease, and cardiovascular disease [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Although not nutritionally essential, food-derived glucose plays an important role in the regulation of postprandial glycemia. Plasma glucose levels, in turn, not only play a role in the control of food intake but also regulate insulin secretion, and peripheral insulin resistance (with its associated glucose intolerance) is closely linked to the development of MetS [ 10 , 13 ]. Additionally, several dietary intervention studies, with epidemiological and clinical data, have suggested the crucial role of fructose, which is present in sucrose and high fructose corn syrup (HFCS), in the MetS epidemic [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Valorizing Coffee Silverskin Based on Its Phytochemicals and Antidiabetic Potential: From Lab to a Pilot Scale

Peixoto

Andrade

Machado

et al. 2022

Foods

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This study investigates the possibility of valorizing coffee silverskin through the recovery of its bioactive compounds using a sustainable extraction method that could be industrially applied. For that, aqueous extracts were prepared using ultrasonic-assisted extraction (laboratorial scale) and, for comparison, a scale-up of the process was developed using the Multi-frequency Multimode Modulated technology. A concentration procedure at the pilot scale was also tested. The three types of extracts obtained were characterized regarding caffeine and chlorogenic acids contents, and the effects on intestinal glucose and fructose uptake (including sugar transporters expression) in human intestinal epithelial (Caco-2) cells were ascertained. The phytochemical contents of the extracts prepared at the laboratory and pilot scale were comparable (caffeine: 27.7 vs. 29.6 mg/g freeze-dried extract; 3-, 4-, and 5-caffeoylquinic acids: 0.19 vs. 0.31, 0.15 vs. 0.42, and 1.04 vs. 1.98 mg/g, respectively; 4- and 5- feruloylquinic acids: 0.39 vs. 0.43 and 1.05 vs. 1.32 mg/g, respectively). Slight differences were noticed according to the extracts preparation steps, but in general, all the extracts promoted significant inhibitions of [1,2-3H(N)]-deoxy-D-glucose and 14C-D-fructose uptake, which resulted mainly from a decrease on the facilitative glucose transporter 2 (GLUT2) and sodium-glucose linked transporter 1 (SGLT1) genes expression but not on the expression of the facilitative glucose transporter 5 (GLUT5) gene. Moreover, a synergistic effect of caffeine and 5-caffeoylquinic acid on sugars uptake was found. The results clearly show that the Multi-frequency Multimode Modulated technology is a viable option to be applied at an industrial level to recover bioactive components from silverskin and obtain extracts with antidiabetic potential that could be used to develop functional food products or dietary supplements.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Valorizing Coffee Silverskin Based on Its Phytochemicals and Antidiabetic Potential: From Lab to a Pilot Scale

Peixoto

Andrade

Machado

et al. 2022

Foods

View full text Add to dashboard Cite

show abstract

Trajectory of metabolic syndrome and its association with knee pain in middle-aged adults

Singh,

Fraser,

Venn

et al. 2023

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms

Wei,

Lu,

Umar

et al. 2023

Bone Res

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Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the association between metabolic abnormalities and OA, particularly in younger individuals. Metabolic abnormalities, such as obesity and type II diabetes, are strongly linked to OA, and they affect both weight-bearing and non-weight-bearing joints, thus suggesting that the pathogenesis of OA is more complicated than the mechanical stress induced by overweight. This review aims to explore the recent advances in research on the relationship between metabolic abnormalities and OA risk, including the impact of abnormal glucose and lipid metabolism, the potential pathogenesis and targeted therapeutic strategies.

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Association of glucose homeostasis and metabolic syndrome with knee cartilage defects and cartilage volume in young adults

Cited by 3 publications

References 31 publications

Valorizing Coffee Silverskin Based on Its Phytochemicals and Antidiabetic Potential: From Lab to a Pilot Scale

Valorizing Coffee Silverskin Based on Its Phytochemicals and Antidiabetic Potential: From Lab to a Pilot Scale

Trajectory of metabolic syndrome and its association with knee pain in middle-aged adults

Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms

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