Association of CASP9, CASP10 gene polymorphisms and tea drinking with colorectal cancer risk in the Han Chinese population

Liu, He; Jiang, Xia; Zhang, Mingwu; Pan, Yue; Yu, Yunxian; Zhang, Shanchun; Ma, Xiaoxin; Li, Qi-long; Chen, Kun

doi:10.1631/jzus.b1200218

Cited by 8 publications

(7 citation statements)

References 43 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given the role of CASP7 in apoptosis and inflammation, the associations among CASP7 and autoimmune diseases and cancer susceptibility are important. Their relevance has been reported in insulin-dependent diabetes mellitus, rheumatoid arthritis, childhood leukemia, and different types of human cancers [18, 21]. Soung et al found that a CASP7 gene inactivating mutation (70 Cys to Tyr mutant) could lead to loss of apoptotic function [18].…”

Section: Discussionmentioning

confidence: 99%

“…Single nucleotide polymorphisms (SNPs) influence the expression or the activities of caspase enzymes. Several CASP genes polymorphisms have been found to be associated with kinds of cancers [17–21] and autoimmune inflammatory diseases, such as rheumatoid arthritis [5], coronary artery disease [22], Kawasaki disease [23], acute pancreatitis [24], and ischemic stroke [25], but the relationship with psoriasis has not been studied. And gene expression profiles showed significant differences in the expression of CASP7 and CASP8 between psoriatic lesions and psoriatic nonlesions.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association Study of the Caspase Gene Family and Psoriasis Vulgaris Susceptibility in Northeastern China

Yao

Hao

Pei

2019

BioMed Research International

View full text Add to dashboard Cite

Background. Abnormal apoptosis of keratinocytes is one of the pathological changes of psoriasis. Caspases (CASPs) are the central engines of apoptosis. Studies to date have shown that some SNPs alter the expression of related genes and lead to changes in disease risk. However, no studies have investigated the associations between gene polymorphisms and the risk of psoriasis in Han population in northeast China. Therefore, we conducted a case-control study to explore this question in Han population of northeastern China. Methods. 540 patients with PsV and 612 healthy age- and sex-matched controls were enrolled in this study. We determined the genotypes of 17 single nucleotide polymorphisms (SNPs) from 11 genes of caspase family by the improved multiplex ligation detection reaction (iMLDR) method. A model-based single SNP frequentist test and haplotype association studies were performed to evaluate the association between SNPs and PsV. Results. In the single SNP tests, rs6704688 in CASP8 was significantly associated with psoriasis vulgaris (PsV) in Han population of northeastern China (P = 0.0169, P’ = 0.0179 under the additive model; P = 0.0126, P’ = 0.0149 under the heterozygous model). In haplotype analyses, the CASP7 haplotype GC was found to be associated with PsV risk (case group versus control group, 47.2% versus 54.4%, respectively, p = 0.0149). Conclusions. Our study presented that the gene polymorphisms of CASP7 and CASP8 were significantly associated with PsV in Han population of northeastern China, which implied the functional relationship between PsV and caspase genes. CASP8 and CASP7 SNPs could be new potential biomarkers for risk stratification and prevention of PsV.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association Study of the Caspase Gene Family and Psoriasis Vulgaris Susceptibility in Northeastern China

Yao

Hao

Pei

2019

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…For example, CASP3 is reported to be referred to the spread of tumor cellulas in gastrointestinal tumors, and targeted CASP3 therapy can inhibit the development of cancer cells [30]. CASP9 is a protein-coding gene, and many reports have shown that CASP9 gene polymorphisms are associated with increased tumor risk, but this conclusion is controversial [31,32]. In gliomas, high expression of PYCARD is related to poor patient prognosis and is used as an independent predictor of chemoresistance [33].…”

Section: Discussionmentioning

confidence: 99%

A Predictive Model Based on Pyroptosis-Related Gene Features Can Effectively Predict Clear Cell Renal Cell Carcinoma Prognosis and May Be an Underlying Target for Immunotherapy

et al. 2022

View full text Add to dashboard Cite

Background and Objective. Recent studies show that pyroptosis-related gene affects tumor cell proliferation, invasion, and migration. But the diagnostic and prognostic value of pyroptosis-related gene in clear cell renal cell carcinoma (ccRCC) is unknown. In the present research, a prognosis model according to pyroptosis-related gene was established to forecast prognosis among patients with ccRCC. Methods. The clinical information and RNA-seq data of ccRCC patients were collected from the TCGA dataset to first explore differential pyroptosis-related genes (PRGs). Univariate Cox regression and consensus clustering were applied to identify ccRCC subtypes. The prognostic PRGs were subjected to LASSO regression analysis to establish a prognostic model and to investigate its value and function. Finally, the relationship of the model immunity checkpoints and immunity infiltration was assessed. Results. The receiver operating characteristic (ROC) showed that the 1-year, 3-year, and 5-year prediction rates of the prognostic model were 0.715, 0.693, and 0.732, respectively. The high-risk group had lower overall survival and higher stage than the low-risk group. Functional enrichment analysis showed that PRGs were significantly enriched mainly in the PPAR pathway, inflammatory pathway, and immune activity. ccRCC patient prognosis correlates with immune components in the microenvironment, and immune checkpoint molecules are significantly expressed in the high-risk group. Immunotherapy may be effective in the high-risk group. Conclusion. Pyroptosis-related gene has an important impact on the progression of ccRCC and can be used as an independent predictor of patient prognosis. In addition, immune checkpoint molecules are significantly upregulated in high-risk populations, which may be a potential target for immunotherapy.

show abstract

“…Studies about an association of CRC with genetic polymorphisms in the CAS9 and CAS10 genes-CRISPR associated-reported a protection against mobile genetic elements [122], against PLA2G4A-phospholipase A group IVA-gene associated inflammation [123], and increased XPCxeroderma pigmentosum associated mutation repair ( [124], see Table 3); all three studies included GT drinking as a modifying factor for the association of CRC with the genotypes; neither study confirmed effects of the polymorphisms studied. In a similar venue Jing et al [125] studied single nucleotide polymorphisms.…”

Section: Crc-association Studiesmentioning

confidence: 96%

Green Tea and Its Extracts in Cancer Prevention and Treatment

et al. 2017

View full text Add to dashboard Cite

Green tea (GT) and green tea extracts (GTE) have been postulated to decrease cancer incidence. In vitro results indicate a possible effect; however, epidemiological data do not support cancer chemoprevention. We have performed a PubMED literature search for green tea consumption and the correlation to the common tumor types lung, colorectal, breast, prostate, esophageal and gastric cancer, with cohorts from both Western and Asian countries. We additionally included selected mechanistical studies for a possible mode of action. The comparability between studies was limited due to major differences in study outlines; a meta analysis was thus not possible and studies were evaluated individually. Only for breast cancer could a possible small protective effect be seen in Asian and Western cohorts, whereas for esophagus and stomach cancer, green tea increased the cancer incidence, possibly due to heat stress. No effect was found for colonic/colorectal and prostatic cancer in any country, for lung cancer Chinese studies found a protective effect, but not studies from outside China. Epidemiological studies thus do not support a cancer protective effect. GT as an indicator of as yet undefined parameters in lifestyle, environment and/or ethnicity may explain some of the observed differences between China and other countries.

show abstract

Association of CASP9, CASP10 gene polymorphisms and tea drinking with colorectal cancer risk in the Han Chinese population

Cited by 8 publications

References 43 publications

Association Study of the Caspase Gene Family and Psoriasis Vulgaris Susceptibility in Northeastern China

Association Study of the Caspase Gene Family and Psoriasis Vulgaris Susceptibility in Northeastern China

A Predictive Model Based on Pyroptosis-Related Gene Features Can Effectively Predict Clear Cell Renal Cell Carcinoma Prognosis and May Be an Underlying Target for Immunotherapy

Green Tea and Its Extracts in Cancer Prevention and Treatment

Contact Info

Product

Resources

About