Association of Candida in Different Stages of Oral Leukoplakia

Dany, A; Kurian, Khalil; Shanmugam, S.; Kailasam, S

doi:10.5005/jp-journals-10011-1081

Cited by 4 publications

(7 citation statements)

References 5 publications

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“…In our study, detection frequency of Candida species was significantly higher in subjects with oral lesions than in those with healthy oral mucosa, thus supporting an association between Candida species and oral lesions. This was similar to studies which employed other methods for isolation of Candida ( 13 , 14 ). Speciation using CHROMagar showed equal or a slight predominant presence of Non albicans comparatively (N=33, 66%) ( Table 1 ).…”

Section: Discussionsupporting

confidence: 85%

Speciation of Candida using CHROMagar in cases with oral epithelial dysplasia and squamous cell carcinoma

et al. 2018

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BackgroundCandida albicans is most frequently isolated from oral cavity but identification of other Candida species such as C. tropicalis, C. krusei, C. glabrata & C. dubliniensis is increasing proportionately. A constant rise in immuno-suppressed patients, widening range of recognized pathogens, and resistance to antifungal drugs are contributing factors which stress the need for species identification of Candida, an opportunistic pathogen. Objectives: 1. To detect the prevalence of Candida albicans and Non albicans Candida albicans (NAC) species in the oral cavity of patients with epithelial dysplasia, Oral squamous cell carcinoma (OSCC) and healthy controls. 2. To identify and differentiate Candidal species using CHROMagar, a differential media.Material and MethodsThe study included smears from 50 patients with histopathological confirmation of epithelial dysplasia & OSCC and 50 normal controls. Candida albicans was identified using Sabouraud dextrose agar media (SDA) as primary culture followed by species identification using CHROMagar on the basis of colony color and morphology.ResultsNon albicans candida predominated (66%) over Candida albicans (34%) in speciation on CHROMagar media in the study group. Non albicans Candida species isolated were C. tropicalis (38%), C. glabrata (24%) and 2 cases showing polyfungal population of C. albicans & C. glabrata.ConclusionsSpecies level isolation of Candida helps in early identification of resistant non Candida strains and prompt treatment of the cases there by preventing the dissemination of infection in case of immuno-compromised individuals. The data presented also supports the use of CHROMagar Candida as a pertinent media for the rapid identification of Candida species directly from clinical specimens in resource challenged settings, which could be helpful in developing appropriate therapeutic strategy and management of patients. Key words:Candida, CHROMagar, epithelial dysplasia, oral cancer.

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Section: Discussionsupporting

confidence: 85%

Speciation of Candida using CHROMagar in cases with oral epithelial dysplasia and squamous cell carcinoma

et al. 2018

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“…This was in accordance with the studies of Dany et al who concluded that 55% of the lesions with moderate dysplasia, 27% of the lesion with mild dysplasia and 18% of the lesion with no dysplasia showed the evidence of Candida whereas 15% of lesions in moderate dysplasia, 32% of lesions in mild dysplasia and 53% of lesion with no dysplasia showed no evidence of Candida . [ 12 ] Similar results were obtained by Barrett et al to determine the frequency of fungal infection in biopsies of oral mucosal lesions. They recorded 6.2% of lesions with mild epithelial dysplasia and 18% of lesions with moderate epithelial dysplasia showing the evidence of Candida .…”

Section: Discussionsupporting

confidence: 76%

Identification of Candida albicans using different culture media and its association in leukoplakia and oral squamous cell carcinoma

Gupta

Abhisheik

Shreedhar

et al. 2019

J Oral Maxillofac Pathol

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“…The studies included in this review assessed Candida infection using smears, oral rinses and staining of biopsies with PAS or GMS (Table 4). Some studies 19,[20][21][22]25,26,31,32,34 used a combination of tests to confirm the presence of Candida. Included studies identified that the prevalence of candidal infection in OL lesions ranged between 6.8% and 100.0%.…”

Section: Discussionmentioning

confidence: 99%

“…Grades of dysplasia ranged from mild to carcinoma-in-situ, and ranged from 20.0% to 100.0%. 22,24,25 One study 29 noted dysplasia was higher in OL lesions infected with Candida (55.9%) compared to OL lesions without candidal infection (33.5%). This finding suggests that OL lesions that are infected with Candida experience increased dysplastic changes, placing them at higher risk of progressing to malignancy.…”

Section: Discussionmentioning

confidence: 99%

Role of Candida infection in the malignant transformation of oral leukoplakia: A systematic review of observational studies

Shukla

Vun

Lov

et al. 2019

Translational Research in Oral Oncology

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The aim of this systematic review was to investigate the malignant transformation of oral leukoplakia (OL) infected with Candida. Literature search was conducted using Medical Subject Heading terms 'leukoplakia', 'neoplasms', 'Candida', 'malignant transformation' and 'oral' and included all results until February 2017. The initial search identified 372 articles, which was consolidated to 16 articles after applying inclusion and exclusion criteria. The occurrence of candidal infection in OL ranged from 6.8% to 100.0%. Only 3 of 16 studies reported malignant transformation rates of leukoplakia with Candida infection. The overall malignant transformation rates reported in these studies were 2.5%, 6.5% and 28.7%. This review supports the contention that candidal infection promotes cellular and dysplastic changes in OL. However, further follow-up studies are recommended to confirm the role of Candida infection in malignant transformation of OL lesions.

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Association of Candida in Different Stages of Oral Leukoplakia

Cited by 4 publications

References 5 publications

Speciation of Candida using CHROMagar in cases with oral epithelial dysplasia and squamous cell carcinoma

Speciation of Candida using CHROMagar in cases with oral epithelial dysplasia and squamous cell carcinoma

Identification of Candida albicans using different culture media and its association in leukoplakia and oral squamous cell carcinoma

Role of Candida infection in the malignant transformation of oral leukoplakia: A systematic review of observational studies

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