Association of better iron status biomarkers and coronary artery disease risk

Zhou, Yunping; Liu, T.; Kang, Peipei; Jia, Chongqi

doi:10.1111/imj.12508

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…The authors concluded that high sTfR and low or high ferritin are predictors of poor outcome in diabetic patients with CAD. Similarly, Zhou et al (2014) investigated the association of iron status parameters with coronary artery disease (CAD) risk (n=540, aged 59.6±9.6) and found that serum iron and TIBC have the strongest association with CAD risk ((AUC 0.92 (0.90-0.95); 85%CI)).…”

Section: Iron Status and Cardiovascular Healthmentioning

confidence: 99%

Iron status in the elderly: A review of recent evidence

Wawer

Jennings

Fairweather‐Tait

2018

Mechanisms of Ageing and Development

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A comprehensive literature review of iron status in the elderly was undertaken in order to update a previous review (Fairweather-Tait et al, 2014); 138 summarised papers describe research on the magnitude of the problem, aetiology and age-related physiological changes that may affect iron status, novel strategies for assessing iron status with concurrent health conditions, hepcidin, lifestyle factors, iron supplements, iron status and health outcomes (bone mineral density, frailty, inflammatory bowel disease, kidney failure, cancer, cardiovascular, and neurodegenerative diseases). Each section of this review concludes with key points from the relevant papers. The overall findings were that disturbed iron metabolism plays a major role in a large number of conditions associated with old age. Correction of iron deficiency/overload may improve disease prognosis, but diagnosis of iron deficiency requires appropriate cut-offs for biomarkers of iron status in elderly men and women to be agreed. Iron deficiency (with or without anemia), anemia of inflammation, and anemia of chronic disease are all widespread in the elderly and, once identified, should be investigated further as they are often indicative of underlying disease. Management options should be reviewed and updated, and novel therapies, which show potential for treating anemia of inflammation or chronic disease, should be considered.

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Section: Iron Status and Cardiovascular Healthmentioning

confidence: 99%

Iron status in the elderly: A review of recent evidence

Wawer

Jennings

Fairweather‐Tait

2018

Mechanisms of Ageing and Development

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“…We speculated that the increase level of ferritin was mainly due to the underlying inflammation. A batch of studies have shown a similar positive correlation between ferritin and the risk of CAD 1,20,22,23,29,30,[44][45][46] . Xu et al found that elevated serum ferritin was independently significantly associated with carotid atherosclerosis in women (Xu et al 2017).…”

Section: Discussionmentioning

confidence: 82%

Association between iron status and incident coronary artery disease: a population based-cohort study

Guo

Mao

et al. 2022

Sci Rep

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Disorders of iron metabolism has been implicated in cardiovascular disease. However, the association of serum iron stores and coronary artery disease (CAD) remains inconsistent. Here, we investigated the associations of serum iron metabolism with the incidence of CAD, the severity of coronary artery stenosis, metabolic biomarkers, and the risk of major adverse cardiovascular event (MACE). A total of 643 CAD patients and 643 healthy controls were enrolled to assess the associations of serum iron status with the presence of CAD, the severity of CAD, and the risk of MACE. Serum iron metabolism and other metabolic markers were measured in all subjects. All statistical analyses were analyzed using SPSS22.0 software and STATA statistical package. Serum level of iron metabolism markers, including serum iron, unsaturated transferrin iron binding capacity (UIBC), Total iron binding capacity (TIBC) levels, in CAD groups was significantly lower than the control group (P < 0.001). UIBC and TIBC were negatively correlated with ferritin in both sexes. Each unit increase of serum iron and TIBC were found to have a protective role for CAD in women (iron: OR 0.794, 95% CI (0.647–0.973), TIBC: OR 0.891, 95% CI (0.795–0.999), P < 0.05). However, high ferritin level was significant associated the CAD incident in both sexes (OR 1.029, 95% CI (1.002–1.058) in men, OR 1.013, 95% CI (1.0–1.025) in women, P < 0.05). Serum iron metabolism markers exhibited no significant association with the severity of CAD. Increased serum level of iron and TIBC levels were found to have a protective role for CAD in women, but not in men. Elevated serum ferritin is independently and positively associated with CAD in men and women.

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“…Fourthly, accumulated iron in adipocytes leads to adipocyte IR by increasing lipolysis and by decreasing insulin-stimulated glucose transport [2]. Adipocyte IR accelerates atherosclerosis [49].…”

Section: Discussionmentioning

confidence: 99%

Low Serum Iron Status Is Associated With Low Incidence of Coronary Artery Disease In Women

Guo

Mao

et al. 2022

Preprint

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Background: Disorders of iron metabolism has been implicated in cardiovascular disease. However, the association of serum ferritin and coronary artery disease (CAD) remains inconsistent. Here, we investigated the associations of serum iron metabolism with the incidence of CAD, the severity of coronary artery stenosis, metabolic biomarkers, and 1-year restenosis after coronary artery revascularization. Methods: A total of 643 CAD patients and 643 healthy controls were enrolled to assess the associations of serum iron status with the presence of CAD, the severity of CAD, and 1-year rehospitalization after revasculation. Serum iron metabolism and other metabolic markers were measured in all subjects. All statistical analyses were analyzed using SPSS22.0 software and STATA statistical package.Results: Serum level of iron metabolism markers, including serum iron, ferritin, unsaturated transferrin iron binding capacity (UIBC), Total iron binding capacity (TIBC) levels, in CAD groups was significantly higher than the control group (P<0.001). UIBC and TIBC were negatively correlated with ferritin in both sexes. Serum level of iron (OR=0.806, 95% CI (0.687-0.944), UIBC (OR=0.919, 95% CI (0.852-0.992), and TIBC (OR=0.864, 95% CI (0.787-0.95) were found to have a protective role for CAD in women (P<0.05, Table 3). The OR for ferritin was significant in the both sexes (OR=1.029, 95% CI (1.002-1.058) in men, OR=1.02, 95% CI (1.005-1.034) in women, P<0.05). Conclusion: Low Serum level of iron, UIBC, TIBC and ferritin levels were found to have a protective role for CAD in women, but not in men. Elevated serum ferritin is independently and positively associated with CAD in men and women.

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Association of better iron status biomarkers and coronary artery disease risk

Abstract: The present study indicated that the combination of SI and TIBC may have the best effect on CAD risk. Further studies are warranted to verify this preliminary result.

Cited by 4 publications

References 38 publications

Iron status in the elderly: A review of recent evidence

Iron status in the elderly: A review of recent evidence

Association between iron status and incident coronary artery disease: a population based-cohort study

Low Serum Iron Status Is Associated With Low Incidence of Coronary Artery Disease In Women

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