The present study indicated that the combination of SI and TIBC may have the best effect on CAD risk. Further studies are warranted to verify this preliminary result.
Background:
The results of published articles on the relationship between the Val158Met polymorphism in the (Catechol-O-methyltransferase)
COMT
gene and the susceptibility of attention-deficit hyperactive disorder (ADHD) are controversial. We conducted an updated meta-analysis of case-control studies to assess the relationship between Val158Met polymorphism in
COMT
gene and ADHD susceptibility.
Methods:
A comprehensive literature search was conducted to identify all the case-control studies on the relationship between the
COMT
gene Val158Met polymorphism and ADHD susceptibility. According to the heterogeneity test results among studies evaluated with
I
2
, the fixed effect model or random effect model was selected as the pooling method. Meta-regression as well as sensitive analysis were used to explore possible causes of between-study heterogeneity. The funnel plot and Harbord test were used to estimate publication bias.
Results:
Finally, seventeen studies that met the inclusion criteria were included. The Val158Met genotype distributions of
COMT
gene in controls were in Hardy–Weinberg equilibrium in all studies. In general, there was no significant association between the
COMT
gene Val158Met polymorphism and ADHD susceptibility in dominant, recessive, and codominant models. The recessive genetic model (
I
2
= 60.8%) showed strong heterogeneity among studies, and still no significant association was found after sensitivity analysis. Subgroup analysis stratified by ethnicity (Asian and Caucasian) also showed that there was no significant association in the above-mentioned three models.
Conclusions:
This updated meta-analysis indicated that the Val158Met polymorphism in the
COMT
gene may not be related to the risk of ADHD. Further researches are needed to confirm these results.
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