2018
DOI: 10.1016/j.mad.2018.07.003
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Abstract: A comprehensive literature review of iron status in the elderly was undertaken in order to update a previous review (Fairweather-Tait et al, 2014); 138 summarised papers describe research on the magnitude of the problem, aetiology and age-related physiological changes that may affect iron status, novel strategies for assessing iron status with concurrent health conditions, hepcidin, lifestyle factors, iron supplements, iron status and health outcomes (bone mineral density, frailty, inflammatory bowel disease, … Show more

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Cited by 50 publications
(36 citation statements)
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References 180 publications
(236 reference statements)
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“…In the present work, elevated Fe concentrations were observed with advancing age. These results contrast somehow with work indicating high prevalence of Fe deficiency anemia in older age [24], but appear in accordance with findings from the US Framingham Heart Study cohort which showed that white Americans aged 67-96 year old were at lower risk of Fe deficiency but had rather elevated Fe stores, based on multiple Fe measures [41]. However, it should be noted that serum Fe is not a good indicator of Fe stores and not a reliable tool for measuring Fe deficiency.…”
Section: Age-specific Changescontrasting
confidence: 99%
See 1 more Smart Citation
“…In the present work, elevated Fe concentrations were observed with advancing age. These results contrast somehow with work indicating high prevalence of Fe deficiency anemia in older age [24], but appear in accordance with findings from the US Framingham Heart Study cohort which showed that white Americans aged 67-96 year old were at lower risk of Fe deficiency but had rather elevated Fe stores, based on multiple Fe measures [41]. However, it should be noted that serum Fe is not a good indicator of Fe stores and not a reliable tool for measuring Fe deficiency.…”
Section: Age-specific Changescontrasting
confidence: 99%
“…In the representative US National Health and Nutrition Examination Survey, higher blood manganese (Mn) concentrations were significantly associated with younger age [23]. Data regarding age-related differences for I are scarce, while Fe deficiency anemia or Fe overload is frequent in older age [24].…”
Section: Introductionmentioning
confidence: 99%
“…In physiological conditions, the iron input-output balance is zero with equivalent amounts absorbed and eliminated, ie one to two mg/d. 18,25 However, to provide one to 2 mg of iron/d to the body, the recommended intake is 10 to 20 mg/d. 14 Indeed, only 5% to 15% of the iron consumed is absorbed, 14 ie low or middle bioavailability.…”
Section: Iron Homeostasis and Bioavailabilitymentioning
confidence: 99%
“…4 In recent decades, numerous studies have focused on the critical role of iron metabolism disruption (with or without iron overload) in diabetes, CKD, cancer and other chronic diseases initiation, progression and development. [5][6][7] Although iron as a trace element has vital roles in the physiology of human beings, it is a redox-active element, so a vicious cycle of iron dis-homeostasis, inflammation and oxidative stress is formed mostly through free radicals induced by iron in chronic diseases, [8][9][10][11][12] and therefore manipulation of iron homeostasis in chronic diseases, especially in DKD, is evaluated in dozens of studies using iron chelators to assess their impacts. [13][14][15][16][17] In fact, iron chelation in these situations means iron re-distribution, not iron excretion.…”
Section: Introductionmentioning
confidence: 99%