Association of average heart rate on 24-hour ambulatory electrocardiograms with incidence of new coronary events at 48-month follow-up in 1,311 patients (mean age 81 years) with heart disease and sinus rhythm

Aronow, Wilbert S.; Ahn, Chul; Mercando, Anthony D.; Epstein, Stanley

doi:10.1016/s0002-9149(96)90077-6

Cited by 72 publications

(46 citation statements)

References 7 publications

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“…Recent studies suggested that an increase in resting heart rate (HR) is also a predictor of cardiovascular and other causes of mortality (6)(7)(8)(9). The resting HR is significantly correlated with the coronary risk factors of blood pressure (BP), serum lipid profiles, plasma glucose concentration, and body mass index (BMI) in Western countries (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Association of Heart Rate With Coronary Risk Factors and Increased White Blood Cell Counts in Healthy Japanese People.

Hasegawa

Watase

2003

JAT

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Elevated resting heart rate (HR) is associated with hypertension in addition to or similar to increased incidence of cardiovascular morbidity and mortality. Subjects with high HR exhibit the characteristic features of insulin resistance syndrome. Sympathetic overactivity underlies this clinical condition. However, the true mechanism of high HR is unclear. We examined the relation between resting HR and age, gender, traditional coronary risk factors, and white blood cell (

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Section: Introductionmentioning

confidence: 99%

Association of Heart Rate With Coronary Risk Factors and Increased White Blood Cell Counts in Healthy Japanese People.

Hasegawa

Watase

2003

JAT

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“…Convincing data on association between tachycardia and unfavorable course of CVD have been received by now. HR is proved to be an independent predictor of development and complicated course of IHD, CHF and other CVDs [8][9][10][11][12][13][14][15]25,26]. In these studies all-causes mortality risk increased significantly in subjects with resting HR over 84 beats per min.…”

Section: Discussionmentioning

confidence: 99%

“…Aronow W. и соавт. обнаружили связь между сердечно-сосудистой смертностью и ЧСС, зарегистрированной при холтеровском мониторировании ЭКГ (ХМ-ЭКГ) [15]. Увеличение ЧСС по данным ХМ-ЭКГ ассоциируется с повышением концентра-ции провоспалительных маркеров в сыворотке крови у лиц среднего и пожилого возраста без клинических признаков ССЗ [16].…”

Section: Methodsunclassified

“…Resting HR over 80-85 beats per min is associated with a risk of arterial hypertension (AH) and atherosclerosis development and is an independent predictor of CVE in subjects with and without CVD symptoms [9][10][11][12][13][14]. Aronow W. et al have revealed relation between cardiovascular mortality and HR recorded during 24 h Holter ECG monitoring (24-h ECG) [15]. Accelerated HR according to 24-h ECG is associated with a higher concentration of proinflammatory markers in blood serum of middle-aged and elderly subjects without clinical signs of CVD [16].…”

Section: High Hr Is a Potential Cardiovascular Risk Factor In Rheumatmentioning

confidence: 99%

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High Heart Rate as a Potential Risk Factor for Development of Cardiovascular Diseases in Women With Rheumatoid Arthritis

Новикова

Попкова

Герасимов

et al. 2012

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To study relationship between heart rate (HR) and traditional risk factors for cardiovascular diseases (TRF for CVD), subclinical structural and functional changes in the heart and vessels, as well as the activity and severity of rheumatoid inflammation in women with rheumatoid arthritis (RA). Material and methods. A total of 291 female patients less than 60 years of age with a definite diagnosis of RA were examined. The control group consisted of 125 women without rheumatic diseases. Aside from clinical symptoms, activity and severity level of RA, the presence of main TRF for CVD were assessed, 24 h Holter ECG monitoring (24-h ECG), duplex scanning of common carotid arteries, transthoracic echocardiography were performed and the serum levels of inflammatory markers were determined. Results. RA patients compared with the control group women had higher values of minimum (52.3±0.4 vs 47.5±0.4; p<0.001) and mean (78.5±0.5 vs 75.5±0.5; p<0.001) HR according to 24-h ECG, after adjustment for main TRF for CVD (age, arterial hypertension, menopause, levels of total cholesterol, triglycerides, high density lipoprotein cholesterol). Accelerated HR in RA directly correlated with an increased joint functional disability index -HAQ, RA severity index, the level of inflammatory markers and administration of leflunomide after adjustment for age (р<0.05). Patients with HR≥86 beats per minute compared with RA patients with values of HR≤71 beats per min had lower total cholesterol (5.84±0.13 vs 5.11±0.17; p=0.001) and low density lipoprotein cholesterol levels (4.06±0.13 vs 3.28±0.18; p=0.001), longer duration, higher activity (Visual Analog Pain Scale, DAS28, extra-articular manifestations of RA, concentration of proinflammatory markers) and severity level of RA (severity index, HAQ, radiological stage III/IV), as well as higher percentage of left ventricular diastolic dysfunction (LVDD) after adjustment for age. Conclusion. According to 24-h ECG, an increase in mean HR values in women with RA is associated with activity, severity of rheumatoid inflammation and LVDD. Prospective studies are needed to determine the role of accelerated HR as a risk factor for development of CVD and the feasibility of preventive measures creation aimed to lower HR to prevent cardiovascular events in RA. Key words: rheumatoid arthritis, heart rate, risk factor for development of cardiovascular diseases Цель. Изучить характер взаимосвязи частоты сердечных сокращений (ЧСС) с традиционными факторами риска сердечно-сосудистых заболеваний (ТФР ССЗ), субклиническими структурно-функциональными изменениями сердца и сосудов, а также активностью и тяжестью ревматоидного воспаления у женщин с ревматоидным артритом (РА). Материал и методы. Обследовали 291 пациентку с достоверным диагнозом РА в возрасте до 60 лет. В контрольную группу были включены 125 женщин без ревматических за-болеваний. Помимо клинических проявлений, степени активности и тяжести РА, оценивали наличие основных ТФР ССЗ, проводили холтеровское мониторирование ЭКГ (ХМ-ЭКГ), дуплексное скан...

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“…La réduction de la fréquence cardiaque apparaît d'ailleurs essentielle à l'activité anti-ischémique des β-bloquants [11]. De surcroît, l'augmentation chronique de la fréquence cardiaque est un facteur prédictif de mortalité chez les coronariens comme dans la population générale [12][13][14][15][16][17][18]. Inversement, la réduction de la mortalité observée dans les cardiopathies ischémiques ou l'insuffisance cardiaque avec les β-bloquants, certains inhibiteurs calciques et l'amiodarone, est attribuée au ralentissement de la fréquence cardiaque qu'ils entraînent [19][20][21][22][23].…”

Section: Fréquence Cardiaque Et Cardiopathies Ischémiquesunclassified

La découverte de l’ivabradine (Procoralan^®), inhibiteur sélectif du courantpacemakerI_f: Une nouvelle approche thérapeutique des cardiopathies ischémiques

Vilaine

2006

Med Sci (Paris)

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Association of average heart rate on 24-hour ambulatory electrocardiograms with incidence of new coronary events at 48-month follow-up in 1,311 patients (mean age 81 years) with heart disease and sinus rhythm

Cited by 72 publications

References 7 publications

Association of Heart Rate With Coronary Risk Factors and Increased White Blood Cell Counts in Healthy Japanese People.

Association of Heart Rate With Coronary Risk Factors and Increased White Blood Cell Counts in Healthy Japanese People.

High Heart Rate as a Potential Risk Factor for Development of Cardiovascular Diseases in Women With Rheumatoid Arthritis

La découverte de l’ivabradine (Procoralan^®), inhibiteur sélectif du courantpacemakerI_f: Une nouvelle approche thérapeutique des cardiopathies ischémiques

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Association of average heart rate on 24-hour ambulatory electrocardiograms with incidence of new coronary events at 48-month follow-up in 1,311 patients (mean age 81 years) with heart disease and sinus rhythm

Cited by 72 publications

References 7 publications

Association of Heart Rate With Coronary Risk Factors and Increased White Blood Cell Counts in Healthy Japanese People.

Association of Heart Rate With Coronary Risk Factors and Increased White Blood Cell Counts in Healthy Japanese People.

High Heart Rate as a Potential Risk Factor for Development of Cardiovascular Diseases in Women With Rheumatoid Arthritis

La découverte de l’ivabradine (Procoralan®), inhibiteur sélectif du courantpacemakerIf: Une nouvelle approche thérapeutique des cardiopathies ischémiques

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Product

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La découverte de l’ivabradine (Procoralan^®), inhibiteur sélectif du courantpacemakerI_f: Une nouvelle approche thérapeutique des cardiopathies ischémiques