Background: Periodontal disease (PD) is a lifestyle-related disease. Risk factors include cigarette smoking and diabetes mellitus (DM). Diabetes mellitus, obesity, hypertension and hyperlipidemia are the main determinants of the metabolic syndrome that may be derived from insulin resistance (IR). In the present study, we examine the relationships between PD and IR-related factors.Methods: This is a cross-sectional study of 9260 non-smoking urban Japanese. The subjects were comprised of three groups, aged 40, 50 and 60 years. Periodontal status was evaluated using the Community Periodontal Index of Treatment Needs (CPITN). Serum samples were analyzed with an automated spectrophotometer.Results: Logistic regression analysis of the data showed that age ( P = 0.0001), sex (male, P = 0.0045), body mass index (BMI, P = 0.017), mean blood pressure (mBP, P = 0.0297) and fasting plasma glucose (FPG, P = 0.0001) were the variables significantly associated with the prevalence of PD. There was a negative correlation between serum low dense lipoprotein cholesterol (LDL) and PD ( P = 0.0001). In the age-adjusted profiles, sex (male, P < 0.01), mBP ( P < 0.01) and FPG ( P < 0.001) had a significantly correlation with PD at age 60, while an inverse correlation between LDL and the prevalence of PD was seen only in the 40-year-old group ( P < 0.001).Conclusion This is the first study showing that mBP and LDL are factors that may determine the prevalence of PD. Lifestyle-related factors could play an important role in the progression of PD.
Elevated resting heart rate (HR) is associated with hypertension in addition to or similar to increased incidence of cardiovascular morbidity and mortality. Subjects with high HR exhibit the characteristic features of insulin resistance syndrome. Sympathetic overactivity underlies this clinical condition. However, the true mechanism of high HR is unclear. We examined the relation between resting HR and age, gender, traditional coronary risk factors, and white blood cell (
A 39-year-old male presented with gross hematuria and left lower abdominal discomfort. Excretory urography showed a left ureteral stone and hydronephrosis. CT scans and magnetic resonance imaging showed a solid mass at the upper pole of the left kidney. Angiography revealed a hypervascular lesion at this area. The laboratory data showed a slightly decreased serum potassium level. In the endocrinological study, the serum deoxycorticosterone (DOC) level was markedly elevated. There was, however, no evidence of hypertension. The operation was performed on November 13, 1992. The tumor was almost separated from the left kidney, but an aberrant artery which divided from the renal artery and penetrated the renal parenchyma was found. Therefore, we had to carry out en bloc removal of the tumor together with the left kidney and the ureter which contained the ureteral stone. Pathological diagnosis was adrenocortical carcinoma. After the operation, hypokalemia and the serum concentration of DOC returned to normal range. Therefore, the tumor was diagnosed as DOC producing adrenocortical carcinoma. The patient was discharged 30 days after the operation with uneventful postoperative course. He received 2.5 g of op'-DDD a day. There was no evidence of distant metastasis or local recurrence 12 months after the operation. Nineteen cases of DOC producing adrenocortical tumor have been reported in the world literature. A case and a review of the literature are herein reported.
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