Association of Heart Rate With Coronary Risk Factors and Increased White Blood Cell Counts in Healthy Japanese People.

Abstract

Elevated resting heart rate (HR) is associated with hypertension in addition to or similar to increased incidence of cardiovascular morbidity and mortality. Subjects with high HR exhibit the characteristic features of insulin resistance syndrome. Sympathetic overactivity underlies this clinical condition. However, the true mechanism of high HR is unclear. We examined the relation between resting HR and age, gender, traditional coronary risk factors, and white blood cell (

Markers of inflammation in acute coronary syndromes: Association with increased heart rate and reductions in heart rate variability

“…26 A population-based study in Japan has supported these observations with a strong correlation between basal HR and total WCC. 27 In healthy individuals subject to mental stress, a similar association was made between HR response and cytokine response. 17 The present study extends these associations to patients with ACS.…”

Elevated Resting Heart Rate Is Associated With White Blood Cell Count in Middle-Aged and Elderly Individuals Without Apparent Cardiovascular Disease

“…17,[20][21][22] These findings indicate that elevated resting HR is closely associated with chronic inflammation, even in relatively healthy individuals. Our results reconfirm this HRinflammation interaction and are compatible with the evidence accumulated to date.…”

“…Epidemiologic studies have demonstrated that HR and/or HR variability is associated with inflammatory biomarkers such as C-reactive protein levels, erythrocyte sedimentation rate, and WBC count in individuals without apparent CAD. 17,[20][21][22] These findings indicate that elevated resting HR is closely associated with chronic inflammation, even in relatively healthy individuals. Our results reconfirm this HRinflammation interaction and are compatible with the evidence accumulated to date.…”

Heart rate on admission is an independent risk factor for poor cardiac function and in-hospital death after acute myocardial infarction

“…Postinfarct sympathetic hyperactivity leads to high levels of extracellular norepinephrine in the heart after AMI, which increases the risk of cardiac arrhythmias and mortality [6][7][8][9]. It is well known that resting heart rate (HR) reflects autonomic activity, and several studies have also shown that resting HR is correlated with hyperglycemia, hyperinsulinemia, metabolic syndrome, and mortality [10][11][12][13][14].…”