Association of Apolipoprotein B and Adiponectin Receptor 1 Genes with Carcass, Bone Integrity and Performance Traits in a Paternal Broiler Line

Cruz, Valdecy Aparecida Rocha da; Schenkel, F.S.; Savegnago, Rodrigo Pelicioni; Grupioni, Natália Vinhal; Stafuzza, Nedenia Bonvino; Sargolzaei, Mehdi; Ibelli, A. M. G.; Peixoto, J. de O.; Ledur, Mônica Corrêa; Munari, Danísio Prado

doi:10.1371/journal.pone.0136824

Cited by 11 publications

(8 citation statements)

References 43 publications

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“…The mechanism is explained by the observations that globular adiponectin stimulates p38 MAPK/ATF-2 activation and suppresses the TOR/p70 S6 kinase pathway [ 146 ]. More precisely, the ADIPOR1 gene is implicated in metabolism and/or fat deposition in broilers [ 147 ]. In chicken adipocytes, adiponectin also regulates mitochondrial biogenesis by inhibiting lipid accumulation and activating the AMPK/ACC signalling pathway [ 148 ].…”

Section: Adiponectinmentioning

confidence: 99%

Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases

Mellouk

Ramé

Barbe

et al. 2018

International Journal of Endocrinology

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Reproduction is a complex and essential physiological process required by all species to produce a new generation. This process involves strict hormonal regulation, depending on a connection between the hypothalamus-pituitary-gonadal axis and peripheral organs. Metabolic homeostasis influences the reproductive functions, and its alteration leads to disturbances in the reproductive functions of humans as well as animals. For a long time, adipose tissue has been recognised as an endocrine organ but its ability to secrete and release hormones called adipokines is now emerging. Adipokines have been found to play a major role in the regulation of metabolic and reproductive processes at both central and peripheral levels. Leptin was initially the first adipokine that has been described to be the most involved in the metabolism/reproduction interrelation in mammals. In avian species, the role of leptin is still under debate. Recently, three novel adipokines have been discovered: adiponectin (ADIPOQ, ACRP30), visfatin (NAMPT, PBEF), and chemerin (RARRES2, TIG2). However, their mode of action between mammalian and nonmammalian species is different due to the different reproductive and metabolic systems. Herein, we will provide an overview of the structure and function related to metabolic and reproductive mechanisms of the latter three adipokines with emphasis on avian species.

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Section: Adiponectinmentioning

confidence: 99%

Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases

Mellouk

Ramé

Barbe

et al. 2018

International Journal of Endocrinology

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“…The TT line has been under selection since 1992, for many 129 generations and several traits, with the goals to increase body weight and carcass yield, 130 improve viability, fertility, hatchability, feed conversion, and reduce abdominal fat 131 (Rosário et al 2009). The TT Reference Population is an expansion of the TT line and 132 was developed from crossing 20 males and 92 females (1:5) in five hatches, yielding 133 approximately 1,500 chickens (Cruz et al 2015;Marchesi et al 2017). From this 134 population we selected 237 offspring and 37 parental chickens (12 males and 25 135 females) for target sequencing.…”

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confidence: 99%

“…More 148 details about the slaughter and phenotypes measurements are available at (Venturini et 149 al. 2014;Cruz et al 2015). 150 151 SNPs selection and custom amplicon design 152 Predicted deleterious SNPs were selected from whole genome re-sequence data 153 previously generated from 14 of the 37 parental animals of the population used in this 154 study (TT Reference population).…”

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confidence: 99%

Association of predicted deleterious single nucleotide polymorphisms with carcass traits in meat-type chickens

Trevisoli¹,

Moreira²,

Boschiero³

et al. 2018

Preprint

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Association of predicted deleterious single nucleotide polymorphisms with carcass traits 44 in meat-type chickens 45 46 Phone number: +55 19 3429 4434 54 55 ABSTRACT 56 57In previous studies, we used genome wide association (GWAS) to identify 58 quantitative trait loci (QTL) associated with weight and yield of abdominal fat, 59 drumstick, thigh and breast traits in chickens. However, this methodology assumes that 60 the studied variants are in linkage disequilibrium with the causal mutation and 61 consequently do not identify it. In an attempt to identify causal mutations in candidate 62 genes for carcass traits in broilers, we selected 20 predicted deleterious SNPs within 63QTLs for association analysis. Additive, dominance and allele substitution effects were 64 tested. From the 20 SNPs analyzed, we identified six SNPs with significant association 65 (p-value <0.05) with carcass traits, and three are highlighted here. The SNP 66 rs736010549 was associated with drumstick weight and yield with significant additive 67 and dominance effects. The SNP rs739508259 was associated with thigh weight and 68 yield, and with significant additive and allele substitution effects. The SNP 69 rs313532967 was associated with breast weight and yield. The three SNPs that were 70 associated with carcass traits (rs736010549, rs739508259 and rs313532967) are 71 respectively located in the coding regions of the WDR77, VWA8 and BARL genes. These 72 genes are involved in biological processes such as steroid hormone signaling pathway, 73 estrogen binding, and regulation of cell proliferation. Our strategy allowed the 74 identification of putative casual mutations associated with muscle growth. 75 76 BACKGROUND 77 Chicken is an important source of protein for human nutrition and a model system in 78 growth and developmental biology (Ellegren 2005). The complete genome sequence of 79 a Red Jungle Fowl female (Gallus gallus gallus), that is considered the ancestor of 80 domestic chicken (G. g. domesticus) (Abplanalp 1992; Cassoli 2007; Dodgson et al. 81 2011), was completed in 2004 (Hillier et al. 2004) and opened the opportunity to 82 explore the molecular control of complex phenotypes such as growth and muscle 83 deposition among other traits. 84 High throughput sequencing of several chicken lines allowed the identification 85 of millions of single nucleotide polymorphisms (SNPs) in the chicken genome (Rubin et 86 al. 2010; Boschiero et al. 2018) and develop high density SNP panels (Kranis et al. 87 2013). SNPs are the most common and frequent DNA variant, with approximately 5 88 SNPs per kilobase (kb) in chicken (Rubin et al. 2010). When located in coding and 89 regulatory regions of genes, they may affect traits of economic interest in animal models 90 and livestock species (Roux et al. 2014).91High-density SNP panels were used in genome wide association studies 92 (GWAS) to identify genomic regions associated with quantitative traits such as body 93

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“…The TT Reference Population is a paternal broiler line originating from the crossing of Cornish, Hampshire, and White Plymouth Rock breeds, which was formed from the expansion of the pure line of broilers by mating 20 males with 92 females (1:5) in 5 hatches, resulting in about 1,500 progeny. Selection of this broiler line has been performed since 1992 in order to increase body weight and carcass traits, decrease abdominal fat percentage, and improve reproductive traits and feed conversion rates (da Cruz et al, 2015).…”

Section: Experimental Population and Phenotypic Traitsmentioning

confidence: 99%

Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line

et al. 2017

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ABSTRACT. Intense selection for production traits has improved the genetic gain of important economic traits. However, selection for performance and carcass traits has led to the onset of locomotors problems and decreasing bone strength in broilers. Thus, genes associated with bone integrity traits have become candidates for genetic studies in order to reduce the impact of bone disorders in broilers. This study investigated the association of the RUNX2 and TNFSF11 genes with 79 traits related to performance, carcass composition, organs, and bone integrity in a paternal broiler line. Analyses of genetic association between single-nucleotide polymorphisms (SNPs) and traits were carried out using the maximum likelihood procedures for mixed models. Genetic associations (P < 0.05) were found between SNP g.124,883A>G in the RUNX2 gene and chilled femur weight (additive plus dominance deviation effects within sex) and with performance traits (additive within sex and additive effects). The SNP g.14,862T>C in the TNFSF11 gene presented genetic associations (P < 0.05) with additive plus dominance deviation effects within sex for performance traits. Suggestive genetic associations (P < 0.10) were found with abdominal fat and its yield. Selection based on SNPs g.14,862T>C in TNFSF11 and g.124,883A>G in RUNX2 could be used to improve performance and carcass quality traits in the population studied, although SNP g.14,862T>C was not in Hardy-Weinberg equilibrium because it was not undergoing a selection process. Furthermore, it is important to validate these markers in an unrelated population for use in the selection process.

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Association of Apolipoprotein B and Adiponectin Receptor 1 Genes with Carcass, Bone Integrity and Performance Traits in a Paternal Broiler Line

Cited by 11 publications

References 43 publications

Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases

Chicken Is a Useful Model to Investigate the Role of Adipokines in Metabolic and Reproductive Diseases

Association of predicted deleterious single nucleotide polymorphisms with carcass traits in meat-type chickens

Association of RUNX2 and TNFSF11 genes with production traits in a paternal broiler line

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