Association of Angiotensin Converting Enzyme Gene I/D Polymorphism of Vitiligo in Korean Population

Abstract

Vitiligo (leukoderma) is an acquired idiopathic hypomelanotic disorder characterized by the circumscribed depigmented patches. Vitiligo is a polygenic disease. The exact pathogenesis is not yet known. The angiotensin converting enzyme (ACE) gene was selected as a candidate gene as ACE plays an important role in the physiology of the vasculature, blood pressure and inflammation, and its relationship with various diseases, including autoimmune diseases, has been widely investigated. The I/D polymorphism of ACE gene in vitiligo patients has not been reported. In this study, we investigated ACE gene polymorphism in 120 vitiligo patients and in 429 healthy volunteers in Korea. The ACE gene genotype distribution (P = 0.032) and allele frequency (P = 0.012) were significantly different between vitiligo patients and healthy controls. This study suggests that the ACE gene polymorphism has a strong association with the development of vitiligo in Korean patients.

Association of vitiligo with HLA‐A2: a meta‐analysis

“…Besides the association of vitiligo with CTLA‐4, vitiligo has been reported to be associated with several other genes (non‐HLA), such as the oestrogen receptor 1 gene, 46 the angiotensin‐converting enzyme gene, 47 the catalase gene, 48 the catechol‐ O ‐methyltransferase gene 49 and the lymphoid protein tyrosine phosphatase gene 50 . These observations, together with our findings in this study, provide evidence and support that the onset of vitiligo is complex and could be affected by multiple genes 1 .…”

Association of glutathione S-transferase gene polymorphisms (GSTM1 and GSTT1) of vitiligo in Korean population

“…The genetic background underlying vitiligo susceptibility has been proposed in various studies (Spritz, 2006;Zhang et al, 2005). Several candidate genes have been proposed for vitiligo susceptibility, including catalase (CAT) gene (Casp et al, 2002;Park et al, 2006), angiotensin-converting enzyme (ACE) gene (Jin et al, 2004a), estrogen receptor 1 (ESR1) gene (Jin et al, 2004b) and cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene (Blomhoff et al, 2005).…”

The association between endothelin‐1 gene polymorphisms and susceptibility to vitiligo in a Korean population

“…In previous studies, we suggested that polymorphisms of angiotensin converting enzyme (ACE), oestrogen receptor 1 (ESR1) and catalase (CAT) contribute to the susceptibility to vitiligo in the Korean population (18–20). Casp et al (21) also reported that the CAT gene might be a susceptibility gene in Caucasian vitiligo patients.…”