The association between endothelin‐1 gene polymorphisms and susceptibility to vitiligo in a Korean population

Abstract

This study suggests that EDN1 is related to the development of vitiligo in the Korean population.

Association of thymic stromal lymphopoietin gene −847C>T polymorphism in generalized vitiligo

“…No difference was found in segmental and localized types. In fact, reported susceptible gene polymorphisms such as catalase (14), CTLA‐4 (15), PTPN22 (16) and NALP1 genes (17) have been mostly identified their clinical significance in generalized type, although EDN1 (18) and Nrf2 (19) were not related to generalized type. The CC genotype frequency in the patients with more, not earlier, than 20 years of onset was higher ( P = 0.012, OR = 1.813, 95% CI = 1.192–2.758), whereas the CT frequency was lower ( P = 0.010, OR = 0.588, 95% CI = 0.382–0.905).…”

The angiotensin-converting enzyme gene insertion/deletion polymorphism in Indian patients with vitiligo: a case-control study and meta-analysis

“…catalase ( CAT ) and catechol‐ O ‐methyltransferase ( COMT ), as well as metabolic regulators, e.g. endothelin‐1 (EDN1), have also been implicated in vitiligo susceptibility, although largely in noncaucasian populations 10–12 …”

Polymorphisms of genes related to endothelial cells are associated with primary biliary cirrhosis patients of Cretan origin

“…Furthermore, HLA [37] and non-HLA gene polymorphisms (MDR3, A2BP1) [38,39] have also been implicated with the onset or progression of PBC. Endothelin polymorphisms have been investigated in cardiovascular diseases and hypertension, but there are also a few reports in other autoimmune diseases such as vitiligo [40], psoriasis [41], scleroderma [42], primary Raynaud [43]. However, no studies have been performed in PBC so far.…”