Association of glutathione S-transferase gene polymorphisms (GSTM1 and GSTT1) of vitiligo in Korean population

Uhm, Yoon Kyung; Yoon, Seo Hyun; Kang, Ik Joon; Chung, Joo‐Ho; Yim, Sung-Vin; Lee, Mu-Hyoung

doi:10.1016/j.lfs.2007.05.006

Cited by 35 publications

(32 citation statements)

References 27 publications

(36 reference statements)

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“…Our results agree with previous reports associating the double‐null genotype with a significantly increased risk of vitiligo 3,4 . However, there are differences in the correlation of vitiligo with one GST null allele: our results agree with those of Uhm et al.…”

Section: Reportsupporting

confidence: 93%

“…Glutathione S‐transferase (GST) is a multigene family of enzymes that detoxify reactive electrophiles, products of oxidative stress and carcinogenic compounds, through conjugation with reduced glutathione 2 . The prevalence of GSTM1 and GSTT1 null polymorphisms in patients with vitiligo has been previously investigated in Korean, 3 Chinese 4 and Italian 5 populations, with partially overlapping results. We carried out a similar study in an Egyptian population.…”

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confidence: 99%

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Glutathione S-transferase M1 and T1 genetic polymorphism in Egyptian patients with nonsegmental vitiligo

Bassiouny¹,

Khorshied²

2012

Clinical and Experimental Dermatology

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Oxidative stress and accumulation of free radicals might play a role in the pathogenesis of vitiligo. Glutathione S-transferase (GST) is a multigene family of enzymes that detoxify oxidative stress products. In this study, genotyping by multiplex PCR of GSTM1 and GSTT1 in 101 women with nonsegmental vitiligo vulgaris and 101 age-matched healthy female volunteers showed that only the GSTM1 null genotype (P=0.04) was significantly overexpressed in patients with vitiligo. Analysis of the combined effect of GSTM1 and GSTT1 genotyping identified a significant association of risk for vitiligo with the GSTT1/GSTM1 double-null type only (P=0.01; OR=2.69; 95% CI 1.12-6.46). Age of onset of vitiligo was significantly earlier in patients with the T1 null genotype (P<0.01) and those with the T1-/M1+ and T1-/M1- combined genotypes (P<0.01 and P=0.01, respectively). In conclusion, the GSTM1 gene and the GSTM1/GSTT1 double-null genotype may be a risk factor for vitiligo in Egyptian patients. Inability to cope with oxidative stresses because of GST deficiency may cause early disease onset.

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Section: Reportsupporting

confidence: 93%

mentioning

confidence: 99%

Glutathione S-transferase M1 and T1 genetic polymorphism in Egyptian patients with nonsegmental vitiligo

Bassiouny¹,

Khorshied²

2012

Clinical and Experimental Dermatology

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“…We also observed a significant association in null alleles of the GSTM1 gene (p<0.001, OR=2.048, 95% CI 1.529-2.743) in a previous study (14). Jin et al reported that a polymorphism of the NLRP1 gene contributed to vitiligo susceptibility.…”

Section: Discussionsupporting

confidence: 79%

“…The causes of vitiligo remain under debate, but it is generally accepted to be an acquired disorder (13). Genetic linkage and association studies have implicated a number of different susceptibility genes, such as glutathione S-transferase (GST), NLR family genes, pyrin domain containing 1 (NLRP1) and tyrosinase (TYR) (14)(15)(16)(17)(18). Liu et al reported that individuals in a sample of Chinese with mutant alleles of the GST gene were at high risk for vitiligo.…”

Section: Discussionmentioning

confidence: 99%

Association study between polymorphisms of CD28, CTLA4 and ICOS and non-segmental vitiligo in a Korean population

Shin¹,

Im²,

Kim³

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. CD28 molecule (CD28), cytotoxic T-lymphocyteassociated protein 4 (CTLA4) and inducible T-cell co-stimulator (ICOS) are important regulators of the immune system. Vitiligo, a common autoimmune skin disorder, is characterized by a loss of melanocytes that results in cutaneous white patches. The aim of the present study was to determine whether or not polymorphisms of the CD28, CTLA4 and ICOS genes are associated with non-segmental vitiligo in a Korean population. To determine the relationships between CD28, CTLA4 and ICOS genes and vitiligo, four single nucleotide polymorphisms (SNPs) associated with the CD28 gene [rs1879877 (promoter, -1198), rs3181097 (promoter, -1059), rs2140148 (intron 1) and rs3116494 (intron 2)], two SNPs associated with the CTLA4 gene [rs231777 (intron 1) and rs231779 (intron 1)] and five SNPs associated with the ICOS gene [rs4270326 (intron 3), rs11571314 (intron 3), rs10183087 (3' untranslated region; UTR), rs4404254 (3'UTR) and rs1559931 (3'UTR)] were selected. Two hundred and thirty-one patients with non-segmental vitiligo (NSV) and 405 healthy controls were enrolled. Genotyping was performed using the restriction fragment length polymorphism technique and direct sequencing. SNPStats, Haploview 4.2 and SPSS 18.0 were used to conduct the analyses. Significant differences were noted between CTLA4 (p<0.05) and NSV, but not CD28 and ICOS (p>0.05). However, these associations disappeared after Bonferroni correction. The CD28, CTLA4 and ICOS genes may not be associated with NSV.

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“…(2009) reported an association with indel rs2234953 (GSTT1+/−) (genotypic P = 1.1E-03, Bonferroni-adjusted genotypic P = 3.3E-03), although a study of 310 cases and 449 controls from Korea found no association with the same marker (Uhm et al ., 2007). Indel rs2234953 is not in HapMap; accordingly, we analyzed 3 SNPs (all imputed) spanning the GSTT1 region (chr22:24,371,141–24,394,284) and found no evidence of association.…”

Section: Resultsmentioning

confidence: 99%

Comprehensive Association Analysis of Candidate Genes for Generalized Vitiligo Supports XBP1, FOXP3, and TSLP

Birlea

Jin

Bennett

et al. 2011

Journal of Investigative Dermatology

116

114

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We previously carried out a genome-wide association study of generalized vitiligo (GV) in non-Hispanic whites, identifying 13 confirmed susceptibility loci. In this study, we re-analyzed the genome-wide data set (comprising 1,392 cases and 2,629 controls) to specifically test association of all 33 GV candidate genes that have previously been suggested for GV, followed by meta-analysis incorporating both current and previously published data. We detected association of three of the candidate genes tested: TSLP (rs764916, P = 3.0E-04, odds ratio (OR)= 1.60; meta-P for rs3806933= 3.1E-03), XBP1 (rs6005863, P = 3.6E-04, OR= 1.17; meta-P for rs2269577= 9.5E-09), and FOXP3 (rs11798415, P = 5.8E-04, OR= 1.19). Association of GV with CTLA4 (rs12992492, P = 5.9E-05, OR= 1.20; meta-P for rs231775= 1.0E-04) seems to be secondary to epidemiological association with other concomitant autoimmune diseases. Within the major histocompatibility complex (MHC), at 6p21.33, association with TAP1-PSMB8 (rs3819721, P = 5.2E-06) seems to derive from linkage disequilibrium with major primary signals in the MHC class I and class II regions.

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Association of glutathione S-transferase gene polymorphisms (GSTM1 and GSTT1) of vitiligo in Korean population

Cited by 35 publications

References 27 publications

Glutathione S-transferase M1 and T1 genetic polymorphism in Egyptian patients with nonsegmental vitiligo

Glutathione S-transferase M1 and T1 genetic polymorphism in Egyptian patients with nonsegmental vitiligo

Association study between polymorphisms of CD28, CTLA4 and ICOS and non-segmental vitiligo in a Korean population

Comprehensive Association Analysis of Candidate Genes for Generalized Vitiligo Supports XBP1, FOXP3, and TSLP

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