Association of an LMP2 Polymorphism with Acute Myeloid Leukemia and Multiple Myeloma

Abstract

Hematological malignancies (HM) are a group of neoplasms derived from the cells of the bone marrow and lymphatic system. Genetic factors leading to susceptibility to HM have been investigated for years but little is known yet. Low molecular weight polypeptide (LMP) 2 and LMP7 genes are important subunits of the immunoproteasome and play significant role in antigen presentation. The polymorphisms of LMP genes have been reported to be risk factors for various types of diseases. The aim of this study was to investigate the association of LMP2 and LMP7 polymorphisms with the occurrence of particular types of HM. A total of 132 patients with HM and 130 control subjects were investigated. No significant difference was obtained in the distribution of genotype and allele frequencies of LMP7 gene in HM patients and the control group. On the other hand, the prevalence of LMP2-AA genotype was found to be higher in acute myeolid leukemia (AML) patients while it was significantly lower in multiple myeloma (MM) cases than in the control subjects. Our results suggested that LMP7 could not be a risk factor for susceptibility to HM, whereas LMP2 polymorphisms could play a role in the development of AML and MM.

Association between LMP2 and LMP7 gene polymorphisms and the risk of gastric cancer: A case-control study

“…These results were consistent with those reported in the majority of previous studies that investigated the association between polymorphisms in LMP2 and LMP7, and other diseases (11-13,22,23). However, Ozbas-Gerceker et al reported that LMP2 plays a role in the development of acute myeloid leukemia and multiple myeloma, whereas LMP7 is not a risk factor for hematological malignancies (24). The discrepancy between these results and the present findings may be attributed to the fact that the same polymorphism may exert different genetic effects on various types of cancer (25,26).…”

Elevated Serum Ferritin Levels in Patients with Hematologic Malignancies

“…Hematologic malignancies are a common disease in Asian Pacific areas (Feng et al, 2013;Jiang et al, 2013;Karami et al, 2013;Khodabandehloo et al, 2013;Kooshyar et al, 2013;Li et al, 2013;Liu et al, 2013;Ozbas-Gerceker et al, 2013;Qin et al, 2013;Shan et al, 2013). As our present study confirmed, the level of serum ferritin of patients with hematologic malignancies was significantly increased.…”

Association between LMP2/LMP7 genetic variability and cancer susceptibility, especially among Asians: evidence from a meta-analysis

“…The eligible studies presented data for several different cancer types, including gastric cancer, cervical cancer, ovarian cancer, hematological malignancy, colorectal cancer and esophageal squamous cell carcinoma. Among these 19 studies, 11 were based on Asian populations [ 7 - 9 , 14 - 16 ], 8 on Caucasian populations [ 10 - 13 ]. Furthermore, the genotyping methods utilized in the studies included PCR-RFLP (RFLP, restriction fragment length polymorphism), Taqman, Sequencing and ARMS-PCR (ARMS, amplification refractory mutation system).…”