Association between LMP2/LMP7 genetic variability and cancer susceptibility, especially among Asians: evidence from a meta-analysis

Wu, Yang; Liu, Dongfang; Zhang, Jingjing; Li, Xiao; Lu, Zipeng; Shi, Guodong; Hao, Yuan; Ge, Yugang; Wu, Pengfei; Wang, Yan; Jiang, Kuirong; Miao, Yi

doi:10.18632/oncotarget.18752

Cited by 6 publications

(4 citation statements)

References 29 publications

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“…The body relies on MHC-I-restricted T cells to eliminate cancer cells. In their study, Wu et al showed that certain polymorphisms of LMP proteins (rs17587 and rs2071543 polymorphisms) were associated with an increased cancer risk in the recessive and homozygote models [ 16 ]. Similarly, in another study, a role was shown for polymorphisms of enzymes involved in phase I metabolism but not phase II metabolism.…”

Section: Resultsmentioning

confidence: 99%

Risk Factors of Esophageal Squamous Cell Carcinoma beyond Alcohol and Smoking

Tarazi

Chidambaram

Markar

2021

Cancers

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Esophageal squamous cell carcinoma (ESCC) is the sixth most common cause of death worldwide. Incidence rates vary internationally, with the highest rates found in Southern and Eastern Africa, and central Asia. Initial observational studies identified multiple factors associated with an increased risk of ESCC, with subsequent work then focused on developing plausible biological mechanistic associations. The aim of this review is to summarize the role of risk factors in the development of ESCC and propose future directions for further research. A systematic search of the literature was conducted by screening EMBASE, MEDLINE/PubMed, and CENTRAL for relevant publications. In total, 73 studies were included that sought to identify risk factors associated with the development of esophageal squamous cell carcinoma. Risk factors were divided into seven subcategories: genetic, dietary and nutrition, gastric atrophy, infection and microbiome, metabolic, epidemiological and environmental and other risk factors. Risk factors from each subcategory were summarized and explored with mechanistic explanations for these associations. This review highlights several current risk factors of ESCC. These risk factors were explored, and explanations dissected. Most studies focused on investigating genetic and dietary and nutritional factors, whereas this review identified other potential risk factors that have yet to be fully explored. Furthermore, there is a lack of literature on the association of these risk factors with tumor factors and disease prognosis. Further research to validate these results and their effects on tumor biology is absolutely necessary.

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Section: Resultsmentioning

confidence: 99%

Risk Factors of Esophageal Squamous Cell Carcinoma beyond Alcohol and Smoking

Tarazi

Chidambaram

Markar

2021

Cancers

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“…Wu et al [17] conducted a meta-analysis of 19 published studies and reported that the PSMB9 rs17587 and PSMB8 rs2071543 SNPs were associated with increased cancer risk in the recessive model [17]. Furthermore, when these data were filtered by cancer type, individuals with the PSMB9 rs17587 SNP were more susceptible to gynecological cancers, while the PSMB8 rs2071543 SNP was associated with increased risk of gastrointestinal and gynecological cancers, especially in Asian populations [17,28]; the meta-analysis did not report results related to bladder cancer. Besides its immune-related role in UBC, PSMB9 serves a clear role in intracellular protein degradation in neurodegenerative diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Despite being essential in cellular and immunological functions, the role of PSMB8 and PSMB9 has not been determined in all types of cancers, as highlighted in at least 78 publications [16], including 19 meta-analyses [17]. Few molecular genetics studies have focused on relationships between these i-proteasome genes and bladder cancer [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Sequence Variants in PSMB8/PSMB9 Immunoproteasome Genes and Risk of Urothelial Bladder Carcinoma

Elhawary¹,

Ekram²,

Abumansour³

et al. 2023

Cureus

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Background: The PSMB8 and PSMB9 immunoproteasome genes are essential in cell processes, such as decisions on cell survival or death, the cell cycle, and cellular differentiation. Because recent evidence has demonstrated an immunological role for proteasomes in various malignancies, including urothelial bladder carcinoma (UBC), we evaluated single nucleotide polymorphisms (SNPs) in PSMB9 and PSMB8. We determined any associations between these SNPs and susceptibility to UBC in the Saudi community.Methods: Samples of genomic DNA were taken from buccal cells of 111 patients with UBC and 78 healthy controls. TaqMan Real-Time PCR was used to determine genotype distributions and allele frequencies for the PSMB9 rs17587 G>A and PSMB8 rs2071543 G>T SNPs. We used SNPStats (https://www.snpstats.net) to choose each SNP's best interactive inheritance model.Results: The PSMB9 rs17587 SNP was associated with the risk of UBC (odds ratio [OR] = 5.21, P < 0.0001). In contrast, the PSMB8 rs2071543 SNP showed no association with UBC risk (OR = 1.13, P = 0.7871). In terms of genotypic distribution, the rs17587 G>A SNP was more frequent in UBC cases than controls in both the dominant (OR = 7.5; 95% confidence interval, 3.7-15.1; P = 0.0051) and recessive (OR = 17.11, 95% confidence interval 5.1-57.4; P = 0.0026) models. Genotypic distribution of the PSMB8 rs2071543 G>T SNP was not significantly different between cases and controls in any interactive inheritance models (P > 0.05).Conclusion: These results suggest a potential role for PSMB9 as a biomarker for increased UBC risk. Discovering more genetic variants within immunoproteasome genes related to antigen presentation could help further our understanding of this risk.

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“…For LMP7 rs2071543 , associated here with AD, it was reported that individuals with the TT genotype had a 3.5-fold higher ovarian cancer risk in Chinese people and 10-fold higher colon cancer risk in Germans than TG and GG genotypes [ 34 ]. The T allele was also found to be associated with cervical cancer similarly to LMP2 rs1351383*A [ 29 ], and, in a meta-analysis, also with other gynecological cancers as well as with gastrointestinal cancers [ 35 ]. In addition, the LMP7 rs2071543*TT genotype had a negative effect on the treatment of chronic hepatitis C virus-infected patients with pegylated interferon-α and ribavirin [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis

Niepiekło-Miniewska

Matusiak

Lesiak³

et al. 2021

Life

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Atopic dermatitis (AD) is a chronic and recurrent inflammatory dermatosis. We recently described an association of the C allele of the single nucleotide polymorphism (SNP) rs26618 in the ERAP1 gene and a synergism of ERAP1 and ERAP2 effects on AD risk. Here, we examined whether polymorphisms of other antigen-presenting machinery genes encoding immunoproteasome components LMP2 and LMP7 and peptide transporter components TAP1 and TAP2 may also affect susceptibility to AD or its outcome. We found that the LMP7 rs2071543*T allele decreased disease risk by about 1.5-fold (odds ratio 0.66, 95% confidence interval 0.44–0.99). On the other hand, the LMP2 rs1351383*C allele reduced the mean age at diagnosis from 23 to 15 years (p < 0.001). Similarly, the TAP1 rs1135216*C allele decreased the mean age at diagnosis from almost 20 to 14 years (p = 0.033). The results are discussed in light of other reports on the role of these polymorphisms in human disease.

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Association between LMP2/LMP7 genetic variability and cancer susceptibility, especially among Asians: evidence from a meta-analysis

Cited by 6 publications

References 29 publications

Risk Factors of Esophageal Squamous Cell Carcinoma beyond Alcohol and Smoking

Risk Factors of Esophageal Squamous Cell Carcinoma beyond Alcohol and Smoking

Sequence Variants in PSMB8/PSMB9 Immunoproteasome Genes and Risk of Urothelial Bladder Carcinoma

Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis

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