Association of allelic polymorphisms of the Matrix Gla-protein system genes with acute coronary syndrome in the Ukrainian population

Garbuzova, Victoria Yu.; Stroy, Dmytro; Dosenko, Victor; Obukhova, Olha Anatoliivna; Атаман, Олександр Васильович

doi:10.7124/bc.0008cc

Cited by 7 publications

(9 citation statements)

References 33 publications

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“…Of these, 3 studies were performed in Caucasians (cases, 1,853; controls, 678) [27,29,30], and 1 study was performed in East-Asians (cases, 215; controls, 67) [28]. The results of pooled ORs in different analysis models are shown in Table 3.…”

Section: Resultsmentioning

confidence: 99%

“…Of these, 3 studies were performed in Caucasian populations [24,25,29], and 1 study was performed in East-Asians [31]. For this polymorphism, the study by Ortlepp et al [25] deviated from HWE.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies including 2,068 cases and 745 controls addressed this issue [27,28,29,30] (Tables 1, 2). Of these, 3 studies were performed in Caucasians (cases, 1,853; controls, 678) [27,29,30], and 1 study was performed in East-Asians (cases, 215; controls, 67) [28].…”

Section: Resultsmentioning

confidence: 99%

“…There were 6 studies [26,27,28,29,31,32] with 2,823 cases and 1,072 controls concerning the Fok I polymorphism and CAD risk; among them, 4 studies were performed in Caucasians [26,27,29,32], and 2 studies were performed in East-Asians [28,31] (Tables 1, 2). For this polymorphism, the studies by O'Halloran et al [27] and Abu el Maaty et al [32] deviated from HWE.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 272 excluded studies, 44 were duplicate publications; 196 were not relevant to VDR gene polymorphisms and CAD risk; 12 were reviews, editorials, or comments; 4 were case reports; 5 were studies that reported on the association between other polymorphisms of the VDR gene and CAD risk; 4 were on patients with diabetes or kidney disorders; 2 were studies without any control group; and 8 were other irrelevant articles. A total of 8 relevant studies (cases, 5,259; controls, 1,981) were finally included based on the inclusion criteria for CAD susceptibility related to the Fok I, Bsm I, Taq I, and Apa I polymorphisms [24,25,26,27,28,29,30,31,32]. Of these, 7 studies were performed in Caucasians [24,25,26,27,29,30,32], and 2 studies [28,31] were performed in East-Asians.…”

Section: Resultsmentioning

confidence: 99%

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Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis

Alizadeh¹,

Djafarian²,

Alizadeh

et al. 2017

Lifestyle Genomics

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Background and Aims:ApaI, FokI, TaqI, and BsmI polymorphisms in the vitamin D receptor (VDR) gene have been reported to be associated with the risk of coronary artery disease (CAD), although the results of previous studies have been inconsistent. The aim of this study was to explore whether these polymorphisms play a role in the genetic susceptibility to CAD. Methods: A comprehensive search of Medline and Embase databases was conducted for studies evaluating the association between the VDR polymorphisms and CAD risk. Odds ratios with 95% confidence intervals were calculated to assess the strength of association in the dominant model, recessive model, allelic model, and genotypes contrast. Results: Nine studies involving a total of 5,259 cases and 1,981 controls were finally included in this meta-analysis. Overall, no significant associations were found between ApaI, FokI, TaqI, and BsmI polymorphisms and the risk of CAD in any of the genetic models (all p ˃ 0.05). Moreover, a subgroup analysis by ethnicity did not reveal a significant relationship between any of the examined polymorphisms and CAD risk in Caucasians and East-Asians for any model (all p ˃ 0.05). Conclusion: Current evidence suggests that the ApaI, FokI, TaqI, and BsmI polymorphisms of the VDR gene might not be associated with genetic susceptibility to CAD. Further well-designed studies with large sample sizes are needed to confirm our results.

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Section: Resultsmentioning

confidence: 99%