Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth

Abstract

To assess whether adiponectin gene (ADIPOQ) polymorphism is associated with intrauterine fetal growth and cord blood adiponectin, we investigated eight single-nucleotide polymorphisms (SNPs; rs182052, rs710445, rs16861205, rs12495941, rs1501299, rs3774261, rs2082940 and rs266729) in ADIPOQ and birth weight and cord blood adiponectin in 526 healthy neonates. We found that the neonates carrying the G allele of rs266729 had a significantly greater birth weight s.d. score than those homozygous for the C allele (CC: À0.06 ± 0.75 versus CG: 0.20 ± 0.64 versus GG: 0.07 ± 0.78; P¼1.65Â10 À3 , adjusted P¼9.90Â10 À3 ). However, this difference was not significant after adjustment for cord blood adiponectin (P¼0.04, adjusted P¼0.26). The rs266729 SNP was strongly associated with cord blood adiponectin; neonates with rs266729 GG had the highest adiponectin (CC: 34.1 ± 20.2 versus CG: 44.3 ± 26.1 versus GG: 54.1 ± 36.7 lg ml -1 , P¼2.80Â10 À9 , adjusted P¼1.68Â10 À8 ). This association remained after adjustment for birth weight s.d. score (P¼6.63Â10 À8 , adjusted P¼3.98Â10 À7 ). Our results suggest that the influence of the rs266729 SNP in ADIPOQ on birth weight may be dependent on circulating adiponectin.

Newborn Adipokines and Birth Outcomes

“…We confirm those observations in a larger cohort using DBS measures and that the associations remain after adjustment for other adipokines, including leptin and important covariates. Single nucleotide polymorphisms of the adiponectin gene have been found to be associated with birthweight and cord blood levels, further supporting these associations . Similar to another large cross‐sectional study of over 300 neonates, adiponectin levels were not associated with ponderal index after adjustment for covariates, suggesting associations with birth size do not signify disproportional growth.…”

A commentary on Association of adiponectin polymorphism with cord blood adiponectin concentrations and intrauterine growth

“…In this context the present study by Saito et al 5 offers an important contribution to elucidate the prenatal growth role of ADI-POQ gene SNPs frequently found in the Japanese population. They analyzed the association of these SNPs with birth size and cord blood adiponectin levels in Japanese neonates born adequate for gestational age (AGA).…”

Association of Adiponectin Gene Polymorphism With Birth Weight in Korean Neonates

“…But blood adiponectin levels of neonates are two or three times higher than those of adults and were positively associated with birth weight and fat mass (Inami et al, 2007;Kadowaki et al, 2006;Kotani et al, 2004;Saito et al, 2012). This may be caused by a lack of negative feedback on adiponectin production, related to the relatively smaller fat mass, low proportion of visceral fat, different cell population (Briana & Malamitsi-Puchner, 2010;Kotani et al, 2004;Saito et al, 2012), and multiple fetal tissues producing adiponectin (Briana & MalamitsiPuchner, 2010;Kadowaki et al, 2006;Kotani et al, 2004).…”

“…A study in Brazil showed that the variant A allele of SNP rs17300539 (-11,391) in the promoter region of ADIPOQ was associated with being born large for gestational age and with higher adiponectin levels at the age of 23-25 years (Bueno et al, 2010). Saito et al (2012) reported that the neonates with the variant G allele of SNP rs266729 (-11,377) in the vicinity of rs17300539 in the ADIPOQ promoter region had significantly greater birth weights and higher cord adiponectin levels. They suggested that the effect of the SNP rs266729 on birth weight is based on its relation to adiponectin level.…”