Association of Adiponectin Gene Polymorphism With Birth Weight in Korean Neonates

Abstract

Adiponectin has been associated with insulin resistance and type 2 diabetes mellitus and possibly fetal growth. Our aim was to assess the association between the single nucleotide polymorphisms (SNPs) of the adiponectin gene (ADIPOQ) and the birth sizes. We investigated four SNPs of ADIPOQ (rs182052, rs2241766, rs1501299, and rs266729) and birth height and weight in 237 healthy full-term neonates. The neonates with the rs182052 G allele had a greater birth weight (p = .043 in the dominant model) and a higher ponderal index (p = .028 in the additive model). The rs2241766 G allele was associated with a greater birth weight (p = .016 in the recessive model). In a logistic regression analysis, the homozygotes for the rs182052 G allele and those for the rs2241766 G allele showed a significant association with a greater birth weight above 90 percentile (OR 2.75, 95% CI 1. respectively). In conclusion, we found an association between rs182052 and rs2241766 and birth weight and ponderal index among healthy neonates and suggested that adiponectin might have some roles in fetal growth.

Association of ADIPOQ, LEP, and FTO gene polymorphisms with large for gestational age infants

“…In this respect, some studies have shown that the GG genotype of the ADIPOQ gene polymorphism is associated with obesity, metabolic syndrome, and increased body fat (Li et al, ; Loos et al, ; Wu et al, ). In a study done on Korean newborns, the GG genotype was strongly associated with weight at birth (Kong et al, ). Similar results have been reported for the FTO polymorphism, which has been shown to be associated with anthropometric and biochemical variables, as well as with excess body weight (Dina et al, ; Frayling et al, ; Gerken et al, ; Liu et al, ; Reuter et al, ; Yang et al, ).…”

Relação de polimorfismos nos genes ADIPOQ, TMEM18, FNDC5 e concentrações séricas de Adiponectina e Irisina com aumento de parâmetros de adiposidade em crianças e adolescentes

“…Estudos mostram a associação desse SNP com diabetes (WANG et al, 2015;Li et al, 2015;BOSTROM et al, 2009). Kong et al (2013), observaram que recém-nascidos com o alelo G para esse SNP apresentavam maior peso ao nascer. Richardson et al (2006), constataram uma relação entre o polimorfismo rs182052 e aumento do Índice de Massa Corporal (IMC).…”