MIR146A and ADIPOQ genetic variants are associated with birth weight in relation to gestational age: a cohort study

Silva, Lívia Reis; Melo, Anderson Sanches de; Salomão, Karina Bezerra; Mazin, Suleimy Cristina; Tone, Luíz Gonzaga; Cardoso, Viviane Cunha; Reis, Rosana Maria dos; Furtado, Cristiana Libardi Miranda; Ferriani, Rui Alberto

doi:10.1007/s10815-022-02532-x

Cited by 2 publications

(1 citation statement)

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“…Meanwhile, the potential pleiotropic effects underpinning the link between birth weight and PCOS were reported. A recent study found that two genetic variants (i.e., rs2910164 C > G and rs182052 G > A) in genes MIR146A and ADIPOQ , both of which were related to PCOS, were associated with birth weight ( 50 ). Although a causal effect of birth weight on PCOS risk was not observed in the present MR analysis, genetically pleiotropic effects of variants that contribute to the associations between birth weight and PCOS cannot be ruled out.…”

Section: Discussionmentioning

confidence: 99%

Fetal genome predicted birth weight and polycystic ovary syndrome in later life: a Mendelian randomization study

Liu,

Gan,

Zhang

et al. 2023

Front. Endocrinol.

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Associations between lower birth weight and higher polycystic ovary syndrome (PCOS) risk have been reported in previous observational studies, however, the causal relationship is still unknown. Based on decomposed fetal and maternal genetic effects on birth weight (n = 406,063), we conducted a two-sample Mendelian randomization (MR) analysis to assess potential causal relationships between fetal genome predicted birth weight and PCOS risk using a large-scale genome-wide association study (GWAS) including 4,138 PCOS cases and 20,129 controls. To further eliminate the maternally transmitted or non-transmitted effects on fetal growth, we performed a secondary MR analysis by utilizing genetic instruments after excluding maternally transmitted or non-transmitted variants, which were identified in another birth weight GWAS (n = 63,365 parent-offspring trios from Icelandic birth register). Linkage disequilibrium score regression (LDSR) analysis was conducted to estimate the genetic correlation. We found little evidence to support a causal effect of fetal genome determined birth weight on the risk of developing PCOS (primary MR analysis, OR: 0.86, 95% CI: 0.52 to 1.43; secondary MR analysis, OR: 0.86, 95% CI: 0.54 to 1.39). In addition, a marginally significant genetic correlation (rg = -0.14, se = 0.07) between birth weight and PCOS was revealed via LDSR analysis. Our findings indicated that observed associations between birth weight and future PCOS risk are more likely to be attributable to genetic pleiotropy driven by the fetal genome rather than a causal mechanism.

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Section: Discussionmentioning

confidence: 99%

Fetal genome predicted birth weight and polycystic ovary syndrome in later life: a Mendelian randomization study

Liu,

Gan,

Zhang

et al. 2023

Front. Endocrinol.

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Micro-RNAs in Human Placenta: Tiny Molecules, Immense Power

Jin

et al. 2022

Molecules

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MicroRNAs (miRNAs) are short non-coding single-stranded RNAs that modulate the expression of various target genes after transcription. The expression and distribution of kinds of miRNAs have been characterized in human placenta during different gestational stages. The identified miRNAs are recognized as key mediators in the regulation of placental development and in the maintenance of human pregnancy. Aberrant expression of miRNAs is associated with compromised pregnancies in humans, and dysregulation of those miRNAs contributes to the occurrence and development of related diseases during pregnancy, such as pre-eclampsia (PE), fetal growth restriction (FGR), gestational diabetes mellitus (GDM), recurrent miscarriage, preterm birth (PTB) and small-for-gestational-age (SGA). Thus, having a better understanding of the expression and functions of miRNAs in human placenta during pregnancy and thereby developing novel drugs targeting the miRNAs could be a potentially promising method in the prevention and treatment of relevant diseases in future. Here, we summarize the current knowledge of the expression pattern and function regulation of miRNAs in human placental development and related diseases.

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MIR146A and ADIPOQ genetic variants are associated with birth weight in relation to gestational age: a cohort study

Cited by 2 publications

References 66 publications

Fetal genome predicted birth weight and polycystic ovary syndrome in later life: a Mendelian randomization study

Fetal genome predicted birth weight and polycystic ovary syndrome in later life: a Mendelian randomization study

Micro-RNAs in Human Placenta: Tiny Molecules, Immense Power

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